Shepard/Garrus, "Joker with a laugh track" (Okay, so I'm sending two, but I couldn't resist.)
Shepard had heard some pretty bad metaphors and some even worse pick-up lines in her life, but 'always like to savor that last shot before popping the heatsink' was among the worst of both and she couldn't help her smirk.
Anything Garrus might have said to try and make it better (doubtful as that was) stopped before it started as canned laughter roared from the speakers in the room. That broke her composure completely and Shepard was soon holding her sides as Garrus argued with Joker and his sitcom laughter over the definition of a private conversation.