#fusobacterium

[brosis-medical]

Revolutionäre Entdeckung: Bakterien Lassen Krebszellen „Schmelzen“

Revolutionäre Entdeckung: Bakterien Lassen Krebszellen „Schmelzen“

Britische Wissenschaftler des King’s College London haben einen bemerkenswerten Durchbruch erzielt. Denn bestimmte Bakterien sind in der Lage, Krebszellen im Kopf- und Halsbereich nahezu vollständig aufzulösen. Diese Entdeckung könnte daher neue Therapieansätze ermöglichen. Bakterien Zerstören Tumorzellen Im Mittelpunkt der Forschung steht das „Fusobacterium“, ein Bakterium aus der Mundhöhle.…

Revolutionäre Entdeckung: Bakterien Lassen Krebszellen „Schmelzen“

[thoughtlessarse]

Type of mouth bacteria ‘melts’ some cancers, study finds

People with head and neck cancers are said to have better outcomes if fusobacterium is found with their cancer

Scientists have discovered that a common type of mouth bacteria can make certain cancers “melt”. Researchers at Guy’s and St Thomas’ and King’s College London said they had been “brutally surprised” to find that fusobacterium – a type of bacteria commonly found in the mouth – appears to have the ability to kill certain cancers. People with head and neck cancers who were found to have this bacteria within their cancer have been found to have much better outcomes, according to a study. Researchers are now looking into the exact biological mechanisms behind the link after the initial findings. Dr Miguel Reis Ferreira, the study’s senior author and a consultant in head and neck cancers at Guy’s and St Thomas’, told the PA news agency: “In essence, we found that when you find these bacteria within head and neck cancers, they have much better outcomes. The other thing that we found is that in cell cultures this bacterium is capable of killing cancer. “What we’re finding is that this little bug is causing a better outcome based on something that it’s doing inside the cancer. So we are looking for that mechanism at present, and it should be the theme for a new paper in the very short-term future.” He added: “This research reveals that these bacteria play a more complex role than previously known in their relationship with cancer – that they essentially melt head and neck cancer cells. However, this finding should be balanced by their known role in making cancers such as those in the bowel get worse.”

continue reading

[shixiaoyang]

Colorectal cancers comprise a complex mixture of malignant cells, non-transformed cells and microorganisms. Fusobacterium nucleatum is among the most prevalent bacterial species in colorectal cancer tissues. Here we show that colonization of human colorectal cancers with Fusobacterium and its associated microbiome, including Bacteroides , Selenomonas and Prevotella species, is maintained in distal metastases, demonstrating microbiome stability between paired primary-metastatic tumors. In situ hybridization analysis revealed that Fusobacterium is predominantly associated with cancer cells in the metastatic lesions. Mouse xenografts of human primary colorectal adenocarcinomas were found to retain viable Fusobacterium and its associated microbiome through successive passages. Treatment of mice bearing a colon cancer xenograft with the antibiotic metronidazole reduced Fusobacterium load, cancer cell proliferation and overall tumor growth. These observations argue for further investigation of antimicrobial interventions as a potential treatment for patients with Fusobacterium -associated colorectal cancer.

Link between fusobacterium and colorectal cancer.  Mice with tumors containing the bacteria DNA treated with Flagyl experienced decreased tumor load. This improvement did not occur with antibiotic that’s not sensitive to fusobacterium

[maidendeals]

[mdsts]

歯周病原因菌8 Fusobacterium Nucleatum 歯周炎の局所から分離される紡錘状の細菌（紡錘菌）の殆どは本菌種です。 本菌の産生するリポ多糖や酪酸等の代謝産物が主要な病原因子です。 急性壊死性潰瘍性歯肉炎からは、殆どの症例でスピロヘータと共に高頻度に検出されます。 本菌は歯面に最初に定着する菌群と共凝集を起こします。

http://dentist.dentalink.or.jp/ogawa/medical/s-geninkin.html

[mdsts]

Fusobacterium nucleatum Fusobacterium nucleatum（F.n.）は、線状の長いグラム陰性嫌気性菌で、デンタルプラークなどでは大きな体積比率で存在しています。ヒトの口腔内に常在し、菌の両端が尖って中心部がやや太いことから紡錘菌とも言われます。F.n.は、歯周病原性菌の１つで、デンタルプラーク形成に中心的役割を担っていて、他の細菌と共凝集することによりバイオフィルムを形成します。  また、糖分解能がなく悪臭（口臭）の原因となる酪酸を産生します。

http://www.bml.co.jp/dentallabo/imformation/virus01.html

[mdsts]

４.Prevotella intermedia 　ﾌﾟﾚﾎﾞﾃﾗ　ｲﾝﾀｰﾒﾃﾞｨｱ 嫌気性グラム陰性桿菌で黒色色素を産出する病原因子としてリポ多糖、コラゲナーゼ、免疫グロブリン切断酵素を有する。 ５.Treponema denticola 　ﾄﾚﾎﾟﾈｰﾏ　ﾃﾞﾝﾃｨｺﾗ 病原因子としてプロテアーゼを有する。 ６.Fusobacterium nucleatum 　ﾌｿﾞﾊﾞｸﾃﾘｳﾑ ﾇｸﾚｱﾀﾑ 嫌気性グラム陰性桿菌、他の細菌との強い共凝集活性を有する。

http://ichiyanagi-sika.com/tiryounonagare1shishuubyoutoha.htm

[mdsts]

Fusobacterium spp.は Bacteroides spp.よりも酸素感受性で,そして Prevotella spp.と同等あるいはそれ以上に酸素感 受性である7).また,集落形成により長時間の培養 を必要とすることから,これらの配慮を欠いた培 養方法が行われた場合には,分離率が低率になる ことが予想される.

http://journal.kansensho.or.jp/Disp?pdf=0760010023.pdf