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Glucarpidase (Mechanism of Action)
Glucarpidase (Mechanism of Action)
In this article, we will discuss Glucarpidase (Mechanism of Action). So, let’s get started. Mechanism of Action Glucarpidase is a recombinant bacterial enzyme that hydrolyzes the carboxyl-terminal glutamate residue from folic acid and classical antifolates such as methotrexate. Glucarpidase converts methotrexate to its inactive metabolites 4-deoxy-4-amino-N10-methylpteroic acid (DAMPA) and…
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Glucarpidase
In this article, we will discuss Glucarpidase (Dosage Overview). So, let’s get started. IndicationsGlucarpidase is indicated for the treatment of toxic plasma methotrexate concentrations (>1 micromole per liter) in patients with delayed methotrexate clearance due to impaired renal function.Limitation of UseGlucarpidase is not indicated for use in patients who exhibit the expected clearance of…
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eating pot makes him high (high dose MTX and CNS toxicity) good thing he's a leucovore (leucovorin is antidote to MTX poisoning) so he can eat a lot of salt but he's allergic to eggs, penne, four sided pizza, salad, and Hi-C which makes him sad (support with sodium bicarb, watch drug interactions with sulfa, phenytoin, tetracyclin, salicylate, vit C and NSaids) he also loves carp caviar but it's expensive (glucarpidase for delayed clearance)
