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[pknoepfl]

CRISPR often damages human embryo chromosomes

CRISPR often damages human embryo chromosomes

An artistic depiction of a CRISPR’d human embryo starting with an image of a real embryo. Knoepfler.

Three new studies reported in preprints all show severe DNA damage to human embryos from CRISPR a surprisingly high percentage of the time including in some cases loss of heterozygosity (LOH). Anywhere from about a quarter to half of CRISPR’d embryos exhibited major genome damage.

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