The study was designed to develop a simple but functional instructional material for Biology instruction. The RNA-DNA kit was developed aligned with the constructs of providing scaffold towards better delivery of difficult lessons in Genetics. The instructional material was conceptualized based on the low performance of BSFT students in Microbial Genetics, thus bringing inside the classroom the model of the ribonucleic acid (RNA) and the deoxyribonucleic acid (DNA) though puzzle chips manipulatives which could help to clearly facilitate their understanding of the Central Dogma of Molecular Biology and to increase their science performance. The material was useful in various topics in Biology including base pairing, Chargaff’s rule, translation, and transcription that are paired with a manual which serves as a guide for students and teachers on how to use the kit. The simplicity and the originality of the designs of RNA-DNA chips which are made of used matchboxes passed the ocular evaluation and strict suggestions and recommendations of experts in Biology. Further, the use of recyclable materials in the kit has a potential for income generation. A quantitative method utilizing questionnaire checklist and twenty item summative tests were also employed to determine how the RNA-DNA kit affects students’ learning. Also, considered is the acceptability of the material for Biology instruction through subjecting to selected group of respondents who are purposively pre-identified MAT-Science students in Technological University of the Philippines and University of Rizal System. Results showed that the material was much acceptable and effective in teaching biology as revealed by the performance of the students which shows significant difference on the level of their performance with the average score of 18.15 verbally interpreted as “High Average” from the 20-item multiple choice type of test given to the respondents. The findings revealed that the utilization of RNA-DNA kit helped to increase Science performance of the students as well as reducing waste in our environment.
