See theres a lot here... yk. Like, I don't really enjoy this ship personally, but I'll try not to let it colour my analysis. Also like... It's hard to analyse a character with so little canon knowledge, because what am I analysing with Laura? I'm gonna try my best here, though
I feel like Laura and Isaac are very different but also very similar. I think they both have this really deep inner rage, and the difference is how they express that. I think Laura is very expressive and emotive with it, like if she's ma,d you'll know. I think there is also an internal aspect to it, though, that she'd really try not to be so externally rageful about the injustices in her life that she can't control.
Isaac, on the other hand, is very much internalized in his rage. You see it a lot in canon with his quickness to jump into fights and how easy it was for him to fall into that rage that Derek was trying to pull out of him in s2. He's really trying his best to keep it all in, though, and it really only comes out when it's pulled from him or if he explodes with all the emotion he's keeping within himself.
I think, if they dated, it would (obviously) have to be an AU. I can see something with forced proximity. Because I really can't see many other ways for Laura and Isaac to get close enough to each other for their similarities to come out. Like, if they were forced to be coworkers or roommates, there would be no way for them to hide that subtle rage and anger from each other over such a long time. It would have to come out, and I think that once it does, the relationship would really start to flow from there.
No matter who Laura is with, I see her as a protector. I think that there's something really intrinsic about the way she took care of Derek after the fire, and while I don't think she'd see Isaac in the same way, I do think she'd be really protective of him. I can also see Isaac being a little perturbed by this, like he's spent a lot of time and energy trying to become someone who can protect himself. I think they very quickly fall into being each other's protectors or guard dogs.
For them, a really powerful moment in their relationship would definitely be one where they are both loudly protecting the other. Because I feel like they would really dislike that in the moment. They would both feel infantilised in some way, as if the other person didn't believe they could defend themselves.
The argument that would ensue would absolutely be earth-shattering.
Whatever comes out of that would fundamentally change their relationship. Because if they come out of it knowing that the other believes in their abilities but would rather they didn't need to use them, then this relationship could WORK. Like seriously. If any other kind of conclusion gets drawn, then I can really see them absolutely just crashing.
Obviously, this is all subjective, like I'm really coming to this with a specific point of view.