I know how you could test the Doctor. Make your 'lair' (for lack of a better term) out of wood. All the wood.
I could build the entire Enrichment Center out of solid ironwood, quadruple-deadlock every door, and surround him on all sides with turrets. And not give him a portal gun. I've seen video of his fifth regeneration. He'd kill me with a kettle and a ball of string.













