#lovastatin

[er-cryptid]

Lovastatin

Names -- Mevacor -- Altoprev

Class -- lipid-lowering agent -- HMG-CoA reductase inhibitor

Use -- adjunctive treatment/managing hypercholesterolemia (primary) and mized dyslipidemia -- primary prevention of coronary heart disease in asymptomatic patients with increased total and LDL cholesterol and decreased HDL cholesterol

Action -- inhibits HMG-CoA reductase -- HMG-CoA reductase is an enzyme responsible for catalyzing an early step in the synthesis of cholesterol

[divine-nonchalance]

“Mobilizing Mushrooms against AIDS Several mushroom species—oyster, shiitake, maitake, turkey tails, and other polypores—have shown anti-HIV activity under certain circumstances. The National Institutes of Health (NIH) funded a small clinical study using oyster mushrooms in conjunction with protease inhibitors. The application, entitled “Anti-Hyperlipidemic Effects of Oyster Mushrooms in the CAM Therapy in the Treatment of HIV/AIDS,” was approved in late 2003 with trials scheduled to start in mid-2005 and to be supervised by the School of Medicine at the University of California, San Francisco (Abrams 2004). Our mushroom farm, Fungi Perfecti, grew a strain of oyster mushrooms for these trials that were frozen, freeze-dried, and powdered for consumption. This may be the first clinical trial funded by the NIH to study the medicinal effects of ingesting mushrooms. Updates will be posted at www.fungi.com. Protease inhibitors, commonly prescribed to combat HIV, interfere with lipid metabolism in the liver, causing an accumulation of “bad” cholesterol, LDL. From the hyperaccumulation of LDL, many patients suffer from arteriolosclerosis, endocrine disruption, and heart disease. Oyster mushrooms contain a natural isomer of lovastatin (an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase), an FDA-approved cholesterol-lowering[…]” Excerpt From: Paul Stamets. “Mycelium Running: How Mushrooms Can Help Save the World."

Paul Stamets

[scholarshipportal]

(via Statins - Atorvastatin, Rosuvastatin, Simvastatin and Lovastatin)

[kingdrawcse]

Dailycompound, Lovastatin

Why does Red Yeast Rice have a lipid-lowering effect? In 1979, Professor Endo Akira of Japan isolated an active chemical "Monacolin K" from Monascus purpureus. Around the same time, Merck Sharp & Dohme, MSD scientists also isolated the compound "Mevinolin" from Aspergillus terreus. The study found that the two teams found the same substance. This HMG-CoA reductase inhibitor has a significant lipid-lowering effect, which is also one of the main active ingredients of monasqu's lipid-lowering effect.

Later, Merck developed the lipid-lowering drug "Lovastatin" and in 1987, it was approved for medical use, the first statin on the market. Lovastatin has few side effects, common side effects include constipation, diarrhea, muscle pain and weakness, etc., but in serious cases, it may cause adverse effects on the musculoskeletal system and liver, and may also lead to birth defects (such as bone malformations, learning disabilities). Pregnant women, breastfeeding women, and patients with liver disease should be cautious about taking monosaccharide health products.

[vivianlesleyy]

Access (Lovastatin) Altocor Online - Affordable Product Delivered Worldwide

Access (Lovastatin) Altocor, Altoprev, Mevacor online with ease. Enjoy the convenience of ordering reasonable products from the comfort of your home. Our online platform confirms swift delivery of quality health products globally. Know-how a seamless process, from browsing our extensive range to doorstep delivery, making healthcare accessible and affordable for everyone, everywhere.

[vivianlesleyy]

MICROBIAL FERMENTATION OF LOVASTATIN AND OTHER BIOACTIVE SECONDARY METABOLITES USING ASPERGILLUS TERREUS

The fungus Aspergillus terreus has dominated the biological production of the “crackerjack” drugs known as statins, particularly lovastatin. The aim of this research was the production of lovastatin which is a known cholesterol-lowering drug, through microbial fermentation using A. terreus. Besides, it also aimed to analyze certain bioactive chemical products and evaluation of such antibacterial and antifungal products, if any produced. Bioactive chemical compounds often referred as secondary metabolites were analyzed using the Gas ChromatographyMass Spectroscopy technique (GC-MS) technique. A. terreus is known to produce a vast variety of important secondary metabolites with high biological activities. The isolation of the natural statins such as lovastatin or mevastatin from A. terreus represents one of the great achievements of industrial Microbiology/Fermentation Technology. Here we report the Aspergillus terreus NBRC (IFO) 31217 (Strain I) and ATCC 11877 (Strain II) produce lovastatin and they also produce important bioactive compounds of high commercial value like isovaline (C5H11NO2), 2-oxo-nvaleric acid and silane etc.

[vivianlesleyy]

Lovastatin Production by Aspergillus terreus (KM017963) in Submerged and Solid State Fermentation: A Comparative Study

Lovastatin (C24H36O5) is a fungal secondary metabolite that inhibits conversion of 3-hydroxy-3- methylglutaryl coenzyme A (HMG CoA) to mevalonate in cholesterol biosynthesis. Lovastatin producing fungus Aspergillus terreus was grown in Solid State Fermentation (SSF) with various agro based wastes and in Submerged Fermentation (SmF) to evaluate the suitable growth medium for maximum production of lovastatin. Eighty three agro based substrates and six different types of SmF media were used for the production. Wheat bran and sprouted wheat were suitable substrates for lovastatin production yielding1.00 mg/G DWS and 1.311 mg/DWS of lovastatin, respectively. None of the SmF medium was found to be suitable for lovastatin production, although all media supported growth of the fungus.

[vivianlesleyy]

The Effects of Lovastatin on Conventional Medical Treatment of Lower Urinary Tract Symptoms with Finasteride

The etiology of benign prostatic hyperplasia (BPH) is still largely unresolved. Multiple partially overlapping and complementary systems (nerve, endocrine, immune, vascular) and local factors are likely to be involved (1), and therefore, several etiologic factors for BPH have been proposed to date (2). Primary interest has been focused on the steroid hormones, especially testosterone estrogen and their metabolites (3). Of the currently used BPH pharmacotherapeutic treatments, only the 5a-reductase inhibitors have been demonstrated to modify the underlying pathology scores and imaging studies (8). The best results have occurred in men with large prostates (> 40 grams), while all the 5a-Reductase Inhibitor’s (5ARI) effect takes approximately 3 to 6 months to occur (9). To our knowledge, of the currently used BPH pharmacotherapeutic interventions only the 5a-RI’s have been shown to modify the underlying pathology.