#lrrk2

[neurosciencenews]

New method developed to target cause of Parkinson's Researchers from Oxford’s Department of Physiology, Anatomy and Genetics (DPAG) have identified how the dysfunction of a key protein, LRRK2, causes the neurons affected in Parkinson’s to lose their ability to effectively clear out cell components that have been damaged. This discovery has enabled the team to find a new way to target and correct this issue, paving the way for a potential new clinical treatment.

[healthinnovations]

Scientists identify a role for main Parkinson's gene in the brain.

Scientists identify a role for main Parkinson's gene in the brain. Thoughts health innovators?

Parkinson’s disease (PD) is a long-term neurodegenerative disorder of the central nervous system whose symptoms generally come on slowly over time, which mainly affects the motor system.  LRRK2 mutations are the most common genetic cause of Parkinson’s disease, however, LRRK2’s normal physiological role in the brain is unclear.  Now, a study from researchers at the National Institutes of Health…

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[neurosciencenews]

Link Between Tuberculosis and Parkinson's Disease Discovered

By studying what LRRK2 does in immune cells called macrophages that are infected with Mtb researchers believe they have uncovered a potential cause of Parkinson's.

The research is in EMBO Journal. (full open access)

[neurosciencenews]

Parkinson's Gene Initiates Disease Outside of the Brain

"We know that brain cells called microglia cause the inflammation that ultimately destroys the area of the brain responsible for movement in Parkinson's," said Richard Smeyne, PhD, Director of the Jefferson Comprehensive Parkinson's Disease and Movement Disorder Center at the Vickie and Jack Farber Institute for Neuroscience. "But it wasn't clear how a common inherited mutation was involved in that process, and whether the mutation altered microglia."

The research is in Brain. (full access paywall)

[skrischer]

My MIS-Adventures with Parkinson's

My Brain is Experiencing Technical Difficulties seen on a t-shirt After 10 years of writing about my “adventures” with Parkinson’s, I think it is time to change it to “My MIS-Adventures” with Parkinson’s. After all, everytime I travel, I find a way to do something to injure myself or someone else. At home, I bump into things that I swear were no where near me. I drop glasses, dishes and all…

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[skrischer]

Comedians Share Insights on Living with Parkinson's

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[neurosciencenews]

Single Protein May Hold Secret to Treating Parkinson's

A new way to regulate protein levels and functions could be the answer to treating devastating neurological conditions.

The research will appear in PNAS.

[neurosciencenews]

Researchers Uncover a New Disruption at the Root of Parkinson's

Leading-edge research by the team of professor Patrik Verstreken (VIB-KU Leuven) has shown for the first time that a malfunctioning stress-coping mechanism in the brain is at the root of Parkinson’s disease. Genetic mutations that cause Parkinson’s disease can prevent synapses – the junctions between neurons where electrical signals are transmitted – from coping with the stress of intense brain activity.

The research is in Neuron. (full access paywall)