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actually when youre really badly hurt time isnt a line its more shaped like a flower! so the petals round the edge are pretty little escape trajectories, some are big and some are small but they all arc away and then back to the centre! and then in the centre in the centre in the centre in the centre in the centre in the in the in the in in in in i i i i i i
Pulmonary metastases in an 8-year-old intact female Golden Retriever.
Mucines et métastase
Les mucines sont des protéines fortement glycosylées qui peuvent être sécrétées ou associées à la membrane. Lorsqu'elles sont ancrées dans les membranes, elles peuvent être considérées comme des cell adhesion molecules (CAM) car sont impliquées dans des interactions cellulaires faibles.
A gauche on a schématiquement des cellules épithéliales normales (jaune), qui sont donc très cohésives l'unes à l'autres pour réaliser leur fonction de barrière grâce à des molécules d'adhésion latéralement (orange), et leur pôle apical est recouvert de mucines (violet).
Lorsqu'une cellule devient cancéreuse elle change de phénotype, c'est-à-dire qu'elle va exprimer des protéines de nature différentes ou dans des proportions anormales dans notre cas. Si elle se met à exprimer des mucines ailleurs que sur le pôle apical, notamment latéralement là où on ne devrait avoir que des molécules d'adhésion, alors les interactions faibles des mucines prend le dessus sur les interactions fortes des molécules d'adhésion et donc on a une perte d'adhésion entre la cellule cancéreuse et ses voisines. La cellule a changé de phénotype, qui n'est plus épithélial mais alors dit mésenchymateux : elle se détache alors et peut se disséminer ailleurs pour former un foyer cancéreux secondaire appelé métastase, à distance du foyer primaire.
Ce changement de phénotype est appelé transition épithélio-mésenchymateuse, et fait intervenir d'autres molécules d'adhésions. On le trouve physiologiquement en embryologie durant la gastrulation.
Ces schémas ont été faits pour mes ED du Tutorat à partir des cours que j'ai retranscrit quand j'étais en première année de médecine. Ma seule source est le professeur de l'époque, et je peux avoir mal compris certaines choses, faire des approximations fausses, etc même si je fais de mon mieux. Croiser les sources permet d'avoir des informations plus fiables. N'hésitez pas à commenter pour discuter des sujets abordés ! Schémas et explications faits entre 2015 et 2016.
a halo is a lot like a chastity cage. prevents reconcile of the angelic body through unification with the divine. marks both their perfection and divinely ordained incompleteness (hollow circle)
time and incompleteness are one and the same. everything is drawn inexorably by longing towards the outside of time. towards completion. any path to the heart will destroy you. you will be run through with striations of untime, the outside pinning and penetrating the body. look up. the stars twinkle because their hearts are full of spite. the gusting of the wind is the envy of the sky battering the trees. look down. the earth trembles and groans with lust. the maggots infest carrion out of love. the weakness in you is the same that turns the heavens. escape is submission. submission is escape. living is a perfect sickness.
the angelic body is a microcosm. reproduces the wholeness, perfection, and integrity of the divine plan. invites also contemplation of said plan’s contradictions, the divine work as violent enforcement of love, the sublimation of divine unity into eternalised subjectivities. and the compromised angelic body, penetrated, expiating, suggests an irruption of providence as violence. an exhibitionist release of the unacknowledged divine impurity siloed within. theres nothing dirtier than angel’s blood. you should use it for lube.
icons as diversions of the flow of divinity. divinity articulated in the interplay of icons. neither of these quite right. icons as snares for gods. gods as parasitic upon icons. icons as remappings of terrain of divinity. divinity as the architectonics of image. —what im getting at is iconoclasm as act of worship.
my love this whole world is violence. not a thing passes between us that is not harm. all is force, all is coercion, all hurt. knowing violence as substrate, though, you have options.
you can deny the truth of the world, seek action, seek modalities of the self, that are not violence. and you will walk through this world blind to the violence that you do, contemptuous of the violence of others - who you presume to do violence beneath you - and you will hurt others like breathing. or you might come to hone your violence. know yourself by the grooves of the inscribed world you direct lifeblood through. some might try a revelatory path, a drawing others up into the same truth we discuss. some might seek a violence that is beauty to them. some might choose to be so little in this world and some might choose to be so much.
but i bless you, all of you, for we have consummated here, and now of us none can claim to be clean again, unless she lies. and if she does we will bless her for it.
