#mpxv

[enicomputer]

Varíola dos macacos: Anvisa orienta clínicas de reprodução assistida

Reprodução: © Dado Ruvic/REUTERS Há potencial para transmissão por material biológico, alerta agência Publicado em 22/08/2022 - 19:09 Por André Richter - Repórter da Agência Brasil - Brasília Ouça a matéria: A Agência Nacional de Vigilância Sanitária (Anvisa) publicou nota técnica (NT 34/2022) com orientações aos centros de reprodução humana (CRHA) assistida envolvendo a varíola dos macacos. Segundo a agência, embora nenhum caso de transmissão do vírus por meio de células de embriões, sangue ou tecidos tenha sido confirmado, existe potencial para a transmissão por material biológico. A suspeita está baseada em estudos científicos limitados, ou seja, que estão disponíveis neste momento.

Por medida de precaução, a Anvisa recomenda que pessoas com sintomas da doença não doem embriões e gametas pelo período mínimo de 21 dias após o início dos sintomas e a cura total das lesões. Pacientes assintomáticos que tenham contato com pessoas com casos suspeitos ou confirmados devem evitar a doação também por 21 dias, a partir do último dia de exposição ao vírus. "A nota técnica alerta aos médicos, aos responsáveis pelos CRHA e aos pacientes que observem sinais ou sintomas sugestivos da doença, ou mesmo se os pacientes tiveram contatos com pessoas ou animais doentes, para que possam realizar criteriosa avaliação de riscos e benefícios, considerando as possíveis complicações relacionadas à infecção com MPXV durante a gravidez", informa a Anvisa. Mais cedo, o Ministério da Saúde lançou a campanha nacional de prevenção à doença.  O ministro da Saúde, Marcelo Queiroga, destacou que o fato de não existir um tratamento específico para a doença não quer dizer que ela não tenha tratamento. Segundo Queiroga, sintomas como dor podem ser amenizados com medidas específicas. Edição: Nádia Franco

Read the full article

[yellowgnomeboots]

About the monkeypox vaccine availability:

I said earlier there is a monkeypox vaccine, but that it’s currently in short supply. The US has secured most of the current doses so it’s probably best just to consider it unavailable for now. That’s because there is only one small company, Denmark’s Bavarian Nordic, that holds the patent and manufactures the vaccine. Their manufacturing facility is currently out of action because they are making changes that will mean they can make other vaccines. They’re not expecting to bring it back online until the end of the year and have said they won’t start making any new monkeypox vaccine doses until next year. The WHO and other pharma companies have offered to help increase production, but it sounds like those offers haven’t been taken up.

Ummm, what. There’s just no one able to make vaccines, due to patents.

article link: https://thespinoff.co.nz/science/22-08-2022/siouxsie-wiles-and-toby-morris-what-to-know-about-monkeypox

[heymrsamerica]

Monkeypox, an illness caused by the Monkeypox virus (MPXV) is spreading around the world. Typically restricted to sub-Saharan Africa, 99% of current cases are occurring in countries that normally do not report MPXV.

MPXV is in the poxvirus family, along with smallpox, cowpox, Vaccinia virus, & others. MPXV is transmitted through close & direct contact with infected animals (non-human mammals), person-to-person via skin contact (and close respiratory droplet), or through contaminated objects.

There are now over 31,000 cases of Monkeypox reported globally, with over 9,400 cases reported in the US. Historically, case demographics of MPXV are 60% men, 40% women. The current outbreak has 99% of cases outside of sub-Saharan African occurring amongst men, particularly men who have sex with men. This does not mean it is a sexually transmitted infection as it can spread by ANY direct contact with infected individuals, but that includes intimate contact.

Monkeypox has a long incubation period, ranging from 5 days to 17 days. Early symptoms are flu-like in nature – once symptoms appear, an individual is contagious. After early symptoms, the characteristic pox rash (blister-like lesions) will appear and progress in 4 phases. Illness typically lasts from 2-4 weeks. During the entire time a person has symptoms they are considered contagious.

There are 2 vaccines available: JYNNEOS & ACAM2000. JYNNEOS is now available for individuals in the US at high risk of MPXV, including those younger than 18. While typically administered subcutaneously, FDA authorized intradermal injection, expanding the current vaccine supply 5-fold. ACAM2000 contains a related virus: Vaccinia virus. It is administered using pin pricks via a bifurcated needle: if you’ve ever seen a smallpox vaccination, this is the same method. It is not available for individuals with immunocompromising conditions.

We can all take measures to prevent infection with MPXV: limit direct contact with potentially infected individuals, good hand hygiene, and practice safe sex. If you are high-risk, contact your local health department for vaccine information. Soon, supply should be expanded for more widespread vaccination.

Sources:

https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0010141

https://onlinelibrary.wiley.com/doi/10.1002/jmv.27931

https://my.clevelandclinic.org/health/diseases/22371-monkeypox

https://www.cdc.gov/mmwr/volumes/67/wr/mm6710a5.htm#F1_down

https://www.medrxiv.org/content/10.1101/2022.06.13.22276353v1

https://www.science.org/content/article/why-the-monkeypox-outbreak-is-mostly-affecting-men-who-have-sex-with-men

https://www.reuters.com/business/healthcare-pharmaceuticals/african-monkeypox-cases-not-concentrated-among-gay-men-experts-say-2022-08-04/

https://www.aad.org/public/diseases/a-z/monkeypox-rash

https://www.cdc.gov/poxvirus/monkeypox/clinicians/clinical-recognition.html

https://www.cdc.gov/poxvirus/monkeypox/prevention/protect-yourself.html

https://www.cdc.gov/poxvirus/monkeypox/transmission.html

https://www.cnbc.com/2022/08/04/cdc-estimates-1point7-million-gay-and-bisexual-men-face-highest-risk-from-monkeypox-.html

https://www.who.int/news-room/questions-and-answers/item/monkeypox

https://www.cdc.gov/poxvirus/monkeypox/clinicians/smallpox-vaccine.html

https://www.cdc.gov/poxvirus/monkeypox/considerations-for-monkeypox-vaccination.html

https://www.fda.gov/vaccines-blood-biologics/vaccines/acam2000-smallpox-vaccine-questions-and-answers

https://www.whitehouse.gov/briefing-room/statements-releases/2022/06/28/fact-sheet-biden-harris-administrations-monkeypox-outbreak-response/

https://www.fda.gov/media/75800/download

https://www.cdc.gov/poxvirus/monkeypox/interim-considerations/overview.html

https://aspr.hhs.gov/SNS/Pages/JYNNEOS-Distribution.aspx

https://www.cdc.gov/poxvirus/monkeypox/response/2022/world-map.html

https://www.cidrap.umn.edu/news-perspective/2022/08/non-endemic-countries-record-first-monkeypox-deaths

https://www.cdc.gov/mmwr/volumes/71/wr/mm7132e3.htm

https://www.nejm.org/doi/full/10.1056/NEJMoa2207323

https://www.fda.gov/vaccines-blood-biologics/vaccines/key-facts-about-monkeypox-vaccine

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