Mar 8, 2024
The NICE guidelines are not enough.
The medical world has not yet accepted that exercise (and other forms of activity, and anything else that provokes PEM) may cause serious in
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The NICE guidelines are not enough.
The medical world has not yet accepted that exercise (and other forms of activity, and anything else that provokes PEM) may cause serious in
Don't be with a nice guy. Be with a good man.
Nice guys are only nice when there's something in it for them. Good men are self-sacrificing because they have good hearts. Nice guys get mad when they don't get their way. Good men get mad at injustice. Nice guys flatter. Good men compliment. Nice guys manipulate people. Good men will tell you the cold hard truth. Nice guys tell beautiful lies. Good men don't care if they piss you off. Nice guys are superficial fakes. Good men are honest and hard-working. Nice guys only work hard when there is something to be gained. Good men work hard no matter what. Nice guys love conditionally. Good men love unconditionally.
Don't be with a nice guy. Be with a good man.
Just found something interesting
𝗡𝗖𝗡𝗘𝗗 𝗶𝘀𝘀𝘂𝗲𝘀 𝘀𝘁𝗮𝘁𝗲𝗺𝗲𝗻𝘁 𝗼𝗻 𝗡𝗜𝗖𝗘 𝗴𝘂𝗶𝗱𝗲𝗹𝗶𝗻𝗲𝘀 𝗳𝗼𝗿 𝗠𝗘/𝗖𝗙𝗦:
“NCNED supports the rejection of graduated exercise therapy (GET) and cognitive behavioural therapy (CBT) as purported treatments for ME/CFS. When guidelines suggest possible treatments that do not provide benefit or indeed may cause harm they should be discontinued.
Importantly, the scientific basis of ME/CFS now speaks for itself.
NCNED has reported in at least four publications (see below) evidence for the pathophysiology of this illness as a calcium ion channel disorder (channelopathy).
Specifically, NCNED has demonstrated impairment of a non-specific calcium (Ca2+) ion channel known as Transient receptor potential Melastatin 3 (TRPM3).
Repeated experiments on natural killer (NK) cells from ME/CFS patients have shown 100% impairment in function associated with TRPM3 dependent Ca2+ transfer into these cells. The distribution of TRPM3 is widespread, in particular brain (including eye, choroid plexus, hippocampus, cerebellum), spinal cord (dorsal horn ganglia), muscle, gastrointestinal, cardiovascular, immune and urogenital systems. Indeed, the distribution of TRPM3 shown to be impaired reflects the symptoms experienced by people with ME/CFS.
As Ca2+ is essential for numerous cellular functions in tissues, impairment of TRPM3 ion channels has a devastating effect. Neither GET nor CBT has a proven role in TRPM3/Ca2+ metabolic therapeutic pathways.
NCNED has also shown restoration of function of NK cells in the laboratory using pharmacotherapeutics known to affect TRPM3. These findings suggest that available drugs may offer benefit to people with ME/CFS. This evidence provides a scientific basis of this illness and a rationale for clinical trials to be undertaken.
NCNED Team
1. Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients. Hélène Cabanas, Katsuhiko Muraki, Natalie Eaton, Cassandra Balinas, Donald Staines, Sonya Marshall-Gradisnik. Mol Med. 2018; 24: 44. Published online 2018 Aug 14. doi: 10.1186/s10020-018-0046-1PMCID: PMC6092868.
2. Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients. H. Cabanas, K. Muraki, C. Balinas, N. Eaton-Fitch, D. Staines, S. Marshall-Gradisnik. Mol Med. 2019; 25: 14. Published online 2019 Apr 23. doi: 10.1186/s10020-019-0083-4PMCID: PMC6480905
3. Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function in Natural Killer Cells From Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients. Helene Cabanas, Katsuhiko Muraki, Donald Staines, Sonya Marshall-Gradisnik Front Immunol. 2019; 10: 2545. Published online 2019 Oct 31. doi: 10.3389/fimmu.2019.02545PMCID: PMC6834647
4. Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment. Helene Cabanas, Katsuhiko Muraki, Natalie Eaton-Fitch, Donald Ross Staines, Sonya Marshall-Gradisnik.Front Immunol. 2021; 12: 687806. Published online 2021 Jul 13. doi: 10.3389/fimmu.2021.687806”
National Institute for health and care excellence has released guidelines for Drug-resistant TB. It is an update on the guidelines published in January 2016. The evidence-based recommendations have...
National Institute for health and care excellence has released guidelines for Drug-resistant TB. It is an update on the guidelines published in January 2016. The evidence-based recommendations have...
OFSTED and CQC criticise Liverpool City Council and Liverpool CCG for “significant weaknesses” in special education needs and disability provision for children and young adults in Liverpool
OFSTED and CQC criticise Liverpool City Council and Liverpool CCG for “significant weaknesses” in special education needs and disability provision for children and young adults in Liverpool
OFSTED and CQC criticise Liverpool City Council and Liverpool CCG for “significant weaknesses” in special education needs and disability provision for children and young adults in Liverpool
Mayor Joe Anderson (Chair of Liverpool City Council’s Health and Wellbeing Board) 6th March 2019
A joint inspection of Liverpool City Council and the Liverpool…
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So I just read the 'NICE' guidelines for BPD & I feel like if you're a decent human being who cares about their job & their clients, all of that wouldn't need to be explicitly written down. But then again, I guess we have explicit stuff for early psychosis treatment & such too. Things that are complex & it helps professions to have a step by step guide when they're not sure.
(Via PIPSQC Spotlight) PIPSQC is pleased to announce that the National Institute for Health and Care Excellence (NICE) has issued a new guideline (NG51) on sepsis: 'Sepsis: recognition, diagnosis and early management.' Background: Sepsis is a leading cause of rapid deterioration in children and the new guideline coincides with an alert from NHS Improvement calling for systemic reform to prevent children deteriorating unnoticed in hospitals from conditions such as sepsis. The UK Sepsis Trust estimates that there are around 150,000 cases of sepsis in the UK each year and 44,000 deaths. Moreover, a report by the NCEPOD found that in over a third (36%) of cases there were delays in identifying sepsis - and that many hospitals had no formal protocols in place to recognise sepsis. NICE says GPs, paramedics, and hospital staff must make 'Could this be sepsis?' the first consideration for anyone unwell with an infection - in the same way the possibility of a heart attack is considered for patients with chest pain. NICE Guideline: The NICE guideline includes recommendations on: Identifying and assessing people with suspected sepsis Risk factors and risk stratification for sepsis Managing suspected sepsis in acute hospital settings and out of hospital The UK Sepsis Trust - Clinical Toolkits: To help health professionals implement the NICE guideline, The UK Sepsis Trust updated its range of clinical toolkits - including the 'Acute Hospital-Inpatients' toolkit: Tool for under 5's Tool for 5-11 year olds Tool for adults and young people Tool for women in pregnancy Further information: For more information about The UK Sepsis Trust, please visit: http://sepsistrust.org/professional/help-my-organisation/ For more information about the NICE guideline, please visit: https://www.nice.org.uk/news/article/sepsis-is-just-as-urgent-as-heart-attack-says-nice Sincerely, The PIPSQC Executive Team E: [email protected] W: http://www.pipsqc.org/