#p cytochrome

[snarp]

"Spironolactone induces CYP3A4 and then is also metabolized by CYP3A4 and then its metabolites will irreversibly inhibit CYP3A4" this is like Jojo's Bizarre Androgen Blocker. shit happening here. Alluka Nanika Xunter takes this androgen blocker. It's Fake

[snarp]

In 2010, the FDA approved the combination drug dextromethorphan/quinidine under the brand name Nuedexta for the treatment of pseudobulbar affect (uncontrollable laughing/crying). Dextromethorphan is the active therapeutic agent in the combination; quinidine merely serves to inhibit the enzymatic degradation of dextromethorphan and thereby increase its circulating concentrations via inhibition of CYP2D6. -- https://en.m.wikipedia.org/wiki/Dextromethorphan#Pseudobulbar_affect

See. You see this. "In 2010." Cytochrome P450 metabolism has been understood and used in drug dev/manufacturing for more than 15 years. I think prescribers should at least be familiar with the terminology and the concept of enzymatic induction/inhibition. They should have to read a couple goddamn Wikipedia pages. I don't think that's too much to ask.

[snarp]

Messaging Github biohackers shit like "do you have a substance that will make my body permanently better at producing CYP3A4 enzyme. And can you publish a Gist"

[snarp]

If you take your morning meds with soymilk, they may hit harder and take longer to wear off. If you do this habitually and then stop drinking soymilk for a while, you may encounter the other kind of problems.

[snarp]

Effects of nicotine on cytochrome P450 2A6 and 2E1 activities - PubMed

CYP2A6 and CYP2E1 activities are not affected by nicotine. The tobacco smoke constituents responsible for the reduced CYP2A6 and increased C

Pharmacokinetic Drug Interactions with Tobacco, Cannabinoids and Smoking Cessation Products - PubMed

Tobacco smoke contains a large number of compounds in the form of metals, volatile gases and insoluble particles, as well as nicotine, a hig

Oh, okay. The thing I need to do to induce P-cytochrome enzymatic action is: start smoking. No! Fuck off!