#cyp3a4

[3liza]

Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: Role of phenolic hydroxyl groups in the resorcinol moiety

In this study, we examined the inhibitory effects of Δ9-tetrahydrocannabinol (Δ9-THC), cannabidiol (CBD), and cannabinol (CBN), the three ma

kind of seems like i shoukd have heard about weed being a CYP3A* inhibitor before now because that is extremely relevant to like 50% of the medications prescribed to humans, and im fairly certain more people currently ingest CBD regularly than grapefruit juice, but we just had a pirate chat member have a problem that was definitely caused by the doctor not being aware of this either and prescribing two different CYP3a4 substrates to a medical CBD patient (clearly marked on their chart) so stay alert

[snarp]

"Spironolactone induces CYP3A4 and then is also metabolized by CYP3A4 and then its metabolites will irreversibly inhibit CYP3A4" this is like Jojo's Bizarre Androgen Blocker. shit happening here. Alluka Nanika Xunter takes this androgen blocker. It's Fake

[snarp]

In 2010, the FDA approved the combination drug dextromethorphan/quinidine under the brand name Nuedexta for the treatment of pseudobulbar affect (uncontrollable laughing/crying). Dextromethorphan is the active therapeutic agent in the combination; quinidine merely serves to inhibit the enzymatic degradation of dextromethorphan and thereby increase its circulating concentrations via inhibition of CYP2D6. -- https://en.m.wikipedia.org/wiki/Dextromethorphan#Pseudobulbar_affect

See. You see this. "In 2010." Cytochrome P450 metabolism has been understood and used in drug dev/manufacturing for more than 15 years. I think prescribers should at least be familiar with the terminology and the concept of enzymatic induction/inhibition. They should have to read a couple goddamn Wikipedia pages. I don't think that's too much to ask.

[snarp]

Messaging Github biohackers shit like "do you have a substance that will make my body permanently better at producing CYP3A4 enzyme. And can you publish a Gist"

[snarp]

If you take your morning meds with soymilk, they may hit harder and take longer to wear off. If you do this habitually and then stop drinking soymilk for a while, you may encounter the other kind of problems.

[snarp]

Going to give gynecologist a panic attack requesting a riskier androgen blocker "because it's reported to be a strong CYP3A4 inducer" (her med school did not believe in P-cytochrome drug metabolism)

[snarp]

4. Where can I acquire metamizole/dipyrone ("go to Mexico" is an unhelpful answer I can't currently do that)

[snarp]

Medical:

I decided to try going off dutasteride for a while to see if the other medication/dietary changes were enough to hold off the hidradenitis suppurativa... 24 days in, the lesions are back.

Dutasteride has a very long elimination half-life: more than a month, in comparison to less than a day for finasteride and spiro. 3-8 weeks is about when I expected problems to start, if they were going to. So, experiment cancelled: I do still need a T blocker. Re-started it today.

(I wanted to see if I could drop it because it's metabolized by my nemesis CYP3A4.)