#pleiotropy

[er-cryptid]

Patreon | Ko-fi  

[studydev]

Cytokines & Receptors P1. of 5

[twotoastedmarshmallows]

This is a great example of how coat colour expression changes with temperature in the siamese cat. In cooler temperatures, the cells produce more melanin and the colour of the fur is dark. This is why siamese cats have dark legs, tails and faces. Ketzel loves sleeping with his front paws tucked under his body and his back legs stretched out. So his front paws are always a few shades lighter.

[biology-geology-beaches-india]

TSRNOSS. Page 186.

[misentropy]

biological  vs. mediated pleiotropy

In a 2013 Nature Reviews Genetics article, geneticist Nadia Solovieff and colleagues outlined all the potential causal mechanisms that might make two traits genetically correlated. They drew a critical distinction between “biological” and “mediated” pleiotropy. The former is the “obvious” inference, which is that the same genes cause both intelligence and longevity. But the latter possibility is that the variables only appear to be genetically correlated, because genes cause one factor, which then goes on to cause the other. That is, if genes cause intelligence, and intelligence (via lifestyle choices etc.) causes a longer lifespan, we’d still see the same genetic correlation, even if those genes have no direct effect on lifespan itself. If true, this would still be pleiotropy of a sort: the genes linked to intelligence are having an indirect effect on lifespan. But as the authors acknowledge in their paper, this “pleiotropy-lite” interpretation of the new findings would mean we don’t yet have knockdown evidence for the genetic “system integrity” idea.

// Source

[datprep]

Just found a really neat example of pleiotropy (when one gene influences two seemingly unrelated phenotypic traits)

Autism and schizophrenia are both associated with deletion of the same region of chromosome 22, but when the deletion happens in childhood it tends to manifest as autism, and when the deletion happens in adolescence or adulthood it tends to manifest as schizophrenia. Neat! 

[designinbiology]

Pleiotropy, robustness and rewiring in the context of complex disease progression. Multiple data integration for the study of disease co-occurrences in an individual.

by NATURE REVIEWS GENETICS

[byosis]

Pleiotropy

A single gene that has several effects

       Sickle Cell Anemia

       Marfan Syndrome