The Women in Prometheus' (Love) Life
Yes, multiple. And no, Pronoia is not the main one. In fact it turns out she only exists if you squint.
His consort and the mother of Deukalion is named Hesione by Akousilaos (fr. 34 Fowler) as well as in the Prometheus Bound (though here their son is not mentioned). She is Klymene in Dionýsios of Halicarnassus, Roman Antiquities 1.17.3 and in a scholion on Odyssey 10.2 (the scholiast claims this to be the most common parentage for Deukalion); in Herodotos' Histories 4.45.1 the name of his wife is Asia.
It is unclear who the mother of Deukalion was in the (Pseudo-)Hesiodic Catalogue of women. In the same scholion on the Odyssey, where both Klymene (attributed to „most authors” and Hesione (attributed to Akousilaos) are names offered for the mother of Deukalion, another one is attributed to Hesiod: Pryneie/Prynoe, which is considered corrupt and occasionally gets emended to Pronoe/Pronoia (no other source has that name). The scholia on Apollonios Rhodios' Argonautica 3.1086 however claims that in Hesiod's Catalogue Prometheus had Deukalion by Pandora, which again tends to be considered an error. Interestingly, Deukalion as the son of Pandora appears also in Strabo's Geography 9.5.23 (although no father is mentioned here and there also exists an account that makes Epimetheus the father of Deukalion).
Then we have Kelaino the daughter of Atlas, by whom Prometheus has Lykos and Chimaireos (Tzetzes on Lykophronn 132, 219); one Axiothea (Tzetzes, on Lykophron 283); and even Pyrrha, who in the scholion on the Argonautica mentioned above is called the mother of Hellen by Prometheus.
And there also exists a tradition in which he is in love with Athena (e.g. schol. Apoll. Rhod. 2.1249) but nothing (good) comes of that.