#rapamycin

[studywithvictory]

5 Oct. 2022, 001/100

I listened to a podcast for once. I usually dislike them since many lack captions and so are difficult to follow. This one by Radiolab was recommended by my teacher -- and thankfully had a full transcript! It's an interesting story about Rapamycin and a scientist that used it on himself to prove its efficacy as an anti-cancer immunosuppressant.

[neurosciencenews]

A new pathway for an anti-aging drug

TRPML1 may contribute to the neuroprotective and anti-aging properties of rapamycin.

[neurosciencenews]

Researchers Studying Drug's Potential to Prevent Alzheimer's

Researchers have known for decades that the hallmark plaques and tangles in the brain associated with Alzheimer's develop long before people experience memory loss.  Ai-Ling Lin, an assistant professor at Sanders-Brown, hopes to demonstrate that low doses of Rapamycin, a drug commonly used as an immunosuppressant for organ transplant recipients, can restore brain function before the disease changes in the brain affect a person's memory.

[aggiepython]

i wondered if the drug rapamycin was named after turnips (Brassica rapa rapa) like maybe it came from a microbe growing on turnips or something, but it turns out it was named after Rapa Nui which is the polynesian name for easter island

[thelovebudllc]

Rapamycin shows promise in treating cold tumors with specific gene mutation

Immune checkpoint inhibitors (ICIs) emerged in the US about 15 years ago as an exciting class of cancer treatments that have achieved complete and durable remissions for thousands of people with end-stage metastatic cancers. However, many other patients have tumors that remain “cold” and unresponsive to these treatments. Now, scientists at Cincinnati Children’s have discovered a specific gene…

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[instantlymaximumblaze]

A New Class of Drug Created That Fights Aging on a Cellular Level : ScienceAlert

A New Class of Drug Created That Fights Aging on a Cellular Level : ScienceAlert https://share.google/W1VkTg86ka9M9RMaA

A New Class of Drug Created That Fights Aging on a Cellular Level

Scientists continue to explore ways we can live longer and ensure those lives are healthier.

...

Researchers from Queen Mary University of London have been testing a new drug called Rapalink-1, building on an existing immunosuppressant called rapamycin that has been shown to extend the life of cells and rodents. In these new tests, Rapalink-1 extended yeast lifespan to a similar degree as rapamycin.

What's more, molecular analysis revealed that the drug increased the production of enzymes that convert a compound made by gut bacteria, called agmatine, into a variety of other chemicals.

Previous studies suggest agmatine can extend the lifespan of the microbes' host. Tests now reveal the conversion of the compound also indirectly affects genes linked to aging, which is part of the reason that Rapalink-1 was effective.

While the science is quite technical, the takeaway is significant: It gives scientists a clearer indication of how yeast cells can be made to live longer, through a method that may apply to human cells.

"By showing that agmatinases are essential for healthy aging, we've uncovered a new layer of metabolic control over TOR – one that may be conserved in humans," says cellular biologist Charalampos Rallis.

"Because agmatine is produced by diet and gut microbes, this work may help explain how nutrition and the microbiome influence aging."

[oddwaysblog]

How RAPACan 1mg Helps in Organ Transplant & Cancer Treatment

RAPACan 1mg is an immunosuppressant medicine. It works to make transplant of liver, kidney, heart, and other organs successful by lowering the functioning of the body’s natural immunity power. Regulated immunity helps the body to accept new organs. 

Rapamycin is a generic medicine and it should be taken as prescribed by the doctor. Based on your schedule and eating habits, your doctor can ask you to take it with or without food. But, make sure that you are always taking it at the same time to fetch the expected results. 

The list of common side-effects includes Nausea, Low blood platelets, Urinary tract infection, High blood pressure, Increased blood lipid level, Headache, Abdominal pain, Anemia (low number of red blood cells), Fever, Diarrhea, Edema (swelling), Joint pain, and others. You are advised to consult your doctor as soon as possible if any of these side-effects persist or cause other kinds of health issues to disturb family/official life. It is important to know that these symptoms may occur differently in some patients. So, do not evaluate the condition yourself. Always discuss your problem with an experienced medical professional to find the solution. 

You essentially need to consult your doctor if suffering with any other underlying diseases or already following other types of medication. Prior discussion before consuming Rapacan 1mghelps to avoid unpredictable situations. Otherwise, your situation might worsen to the next level. Pregnant ladies and lactating mothers must consult a doctor before taking RAPACan 1 mg Tablet. Your doctor might ask you to undergo some specific tests to ensure that consuming this medicine is safe and will not cause any kind of health issues. Immediately talk to your doctor if you experience fatigue, persistent headache, digestive issues, or other symptoms after starting this medicine.      

Use 

This medicine can be used for several diseases including:

Prevention of kidney transplant rejection

Breast cancer

Kidney cancer

Pancreatic cancer

Lung cancer

Side Effects

Like other medicines, Rapamycin also causes some side effects but they disappear themselves as bodily functions conform to this medicine. On the other hand, immediately consult your doctor if you witness a new kind of health issue and it does not disappear in 1-2 days.  

Some common side effects are: 

Edema, 

Increased blood lipid level, 

High blood pressure, 

Abdominal pain, 

Diarrhea, 

Headache, 

Fever, 

Urinary tract infection, 

Anemia, 

Nausea, 

Joint pain, 

Thrombocytopenia

Some patients may witness other Rapamycin side effects as well. So, remain watchful for your health and daily routine. 

How to use it?

Buy Rapamycin onlineand consume as prescribed by your doctor. Based on your routine, your doctor may ask you to take it with or without food. However, it is important to swallow as a whole. Do not check or crush before taking. Also make sure that you are taking it at the same time daily. Random timing makes it less effective. In addition, it becomes difficult for the body to absorb properly. 

How does this tablet function?

Buy Rapacan 1mg tabletand consume as prescribed by the doctor. It is an immunosuppressant medicine and brings significant changes to the body by reducing the efficiency and capabilities of the body’s natural immunity power. However, it plays a key role in making organ transplant a success. 

Safety Advice

Breast Feeding: Do not even think to consume if you are breastfeeding. The salt will mix with the breast milk and might prove highly harmful for the brain health and nervous system of the baby. 

Alcohol: Exact side effects are difficult to mention but there are chances to struggle with several critical conditions if you consume alcohol while consuming Rapamycin.  

Pregnancy: Buying Rapamycin and using it during pregnancy proves highly unsafe. It may stop the baby from developing. Additionally, you might experience some other kinds of issues like weight loss, bleeding, swelling, and others. 

Kidney: It is safe for kidney patients to consume. Consult your doctor before starting. 

Driving: You can drive after taking. It does not affect your driving ability in any way. 

Liver: Liver patients essentially have to be more careful before starting. You are suggested to go for the dose adjustment. Prior discussion with the doctor helps to avoid any unpredictable condition and fetch expected results.  

What to do if you miss the dose of Rapacan tablet?

Do not panic or become hyperactive if you forget to take your dose on the scheduled time. Try taking it as soon as possible when you remember and continue your schedule from the next day. 

Substitutes

For information only. Consult your doctor before changing the brand or quantity. 

RAPACan 1mg Tablet

Siromus 1mg Tablet

Sirova 1mg Tablet

Raparen 1mg Tablet

Sirotor Tablet

Useful Tips:

Prevents organ rejection

Avoid grapefruit

Avoid sunbeds, sunscreen, and direct sunlight

Monitor your sugar levels on regular basis

Facts:

Habit forming:NO

Action Class: Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors

Therapeutic Class: ANTI NEOPLASTICS

Chemical Class: Macrolide Lactams

Interaction with drugs:

Rapacan 1mg tablet is a very strong medicine therefore avoid using it with any other strong drug. Careless addition with other remedies might bring some undesirable results. Such results may be severe to life-threatening. Here, we are giving some points which help you make an informed decision. 

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route) Life-threatening: Do not include it with your ongoing medication. It causes life threatening situations.  

Natalizumab (Injection Route) Life-threatening: Severe brain infections are some common causes if you consider combining it. 

Carbamazepine (Oral Route) Severe: Your doctor may ask for a dose adjustment. Never think of consuming your own. 

Enzalutamide (Oral Route) Severe: Continuous observation of a skilled and experienced doctor is necessary to avoid any untoward situation. 

FAQ:

Q. Does Rapacan 1mg tablet affect fertility?

A. Salts of Rapacan 1mg tablets might decrease sperm count in some patients during the treatment. Talk to your doctor to confirm further information.  

Q. Can Rapacan 1mg tablet aggravate kidney disease?

A. Prolonged usage of Rapacan might develop haemolytic uraemic syndrome (a considerable kidney disease). 

Q. What should I know before taking the Rapacan 1mg tablet?

A. Rapacan should not be combined with grapefruit in any way. Talk to your doctor if you are intolerant to lactose and sucrose. 

Q. Can a Rapacan 1mg tablet cause diabetes?A. Rapacan 1mg tablets may affect blood sugar levels. Regularly monitor your blood sugar level and talk to your doctor for more information. 

[oddwaysblog]

How RAPACan 1mg Helps in Organ Transplant & Cancer Treatment

Purchase RAPACan 1mg from Oddway International to aid your cancer treatment and organ transplant journey. RAPACan is a potent medication based on Rapamycin that aids in managing the immune system to promote successful transplants and address specific cancers. Find out about side effects and precautions today. Discover the advantages of RAPACan 1mg by Oddway International. RAPACan, a reliable drug based on Rapamycin, supports successful organ transplants and effective cancer therapy. Prior to use, consult your physician and keep abreast of potential side effects in order to use it safely.