For the back story so far! Warning! Mentions of blood, out of body horror, vomiting, and more! I think vomiting teeth is considered body horror?
Doctor Doom usually wanted Reed Richards dead, to prove his intellectual superiority. But, what better way then to, instead of killing him, turn him into a beast?
So, that's what Doom did. He shot him with a spell green as villainous ichor, and forced his magic deep in the man's stretchy ribs. It took Reed several days to actually transform though, since it needed time to burrow in.
After several days, Reed had fallen ill with the flu, or so he though. His skin felt hot, he shivered, his throat itched—the full nine yards of typical flu/general illness symptoms. He only realized that something was wrong when he had his first fever dream of many.
Him coughing blood, his fingers aching, nails growing sharper. He woke up drenched in sweat that night. Susan was exhausted due to being woke up from his panic, but certainly didn't show it. She figured that it would be disheartening if she did that, especially when she thought he was horribly sick.
He apologize, embarrassed about a simple dream waking him up in that state, to the point of the corners of his eyes burning with strange tears. He tried to ignore it that night. He tried to cuddle with her to make himself not feel so unsettled. He was, unfortunately the temperature of metal under the sun.
She didn't push him away, even if he was making her melt.
He thought it would go away after a few days, but he was wrong. He stayed hot, cold, exhausted, and ready to just give up. He eventually fell asleep one night, rattled and feverish on Ben Grimm's arm, looking pitiful. That night was a fever dream even worse. It involved his teeth pushing out, growing and aching, before falling out, new ones growing in. They barely fit his mouth. He found himself vomiting up canine teeth in the dream.
He woke up, frazzled and flustered. He told Benjamin about the dream, a nightmare he called it. Ben tried to soothe him by saying that fever dreams could just be like that sometimes. He didn't think that was the case.
He didn't know much about dreams or their specific meanings. He was a scientist, but he certainly didn't have knowledge of dreams just on hand. Especially about the ones he'd been having.
He found himself slowly getting more bothered, finding it hard to focus as the full moon grow closer by the day. Johnny had jokingly called him a werewolf, and offered to get him a silver cage. Reed didn't find jokes on his unease too amusing.
"..." Johnny Storm had encountered Doctor Strange one of the days he had been outside. Both of them doing something mundane, and Johnny told Strange about how Reed had been doing. The flaming man had decided to continue telling him everything, especially about the weird 'fever dreams.'
Doctor Strange gave a, ironically enough, strange look at that. Especially at the detail of vomiting canine teeth. He decided to visit later.