#ribavirin

[oaresearchpaper]

Serum IL-12p70 and TLR 7 gene expression in Egyptian patients infected with HCV and treated with Sofosbuvir, Ribavirin and/or Pegylated interferon

Chronic hepatitis C virus infection is one of the most important health problems in Egypt. The purpose of this study was to assess the efficacy, and tolerability of two therapeutic modalities, dual (Sofosbuvir+ribavirin)and triple (sofosbuvir + ribavirin + peg-interferon), in treating Egyptian patients infected with HCV genotype-4. In addition, we determined serum IL-12p70 and TLR7 gene expression in patients infected with HCV with and without treatment, compared to the normal volunteers. No significant changes in serum creatinine and fasting blood glucose concentrations were reported at the end of the treatment with dual and triple therapy and after 3 months of follow up. Pateints infected with HCV showed a non significant change in the relative quantitation of TLR7 gene expression, and a significant elevation in serum IL-12p70 concentration (161.73%, p

[oaresearchpaper]

Hepatitis C virus (HCV) is one of the leading causes of liver cirrhosis. Adjunctive therapy of ribavirin and interferon is commonly used against HCV infection, but it has wide diverse side effects. Currently, there is an urgent need for the development of new alternate therapy for combating HCV infections. This study is aimed to assess the efficacy of sofosbuvir plus ribavirin treatment in HCV cirrhotic patients (genotypes 2 and 3), viral drug response and to prevent progression of cirrhosis by eradication of HCV. Sample of 62 HCV cirrhotic patients were collected from the Gastroenterology ward of local hospital. Multiplex and real-time PCR were used to determine the genotypes and viral load respectively. The subjects were divided into two groups; A and B; A (HCV genotype 2), B (HCV genotype 3) infections. Group A and B received sofosbuvir (400 mg daily) plus ribavirin (200 mg twice daily) for 3 and 6 months respectively. The blood samples were further analyzed for the presence of viral RNA.Sustained Virologic Response (SVR) was shown by 88.70% of HCV cirrhotic patients. Group A patients (genotype 2) disclosed a good response to sofosbuvir (SVR 92%) as compared to group B (genotype 3; 88%). The SVR of group B patients was 70% and 88% after 12 and 24 weeks of treatment respectively. Sofosbuvir plus ribavirin may be prescribed for the treatment of HCV genotype 2 (3-months) and genotype 3 patients (6-months) with liver cirrhosis.

[tommyysscott]

How Expensive Is Ribavirin Copegus Rebetol Virazole

Generic RIBAVIRIN / Brand COPEGUS REBETOL 100mg / 200mg Capsule is prescribed for treating infections chronic hepatitis C virus (HCV). This medicine is co-administered with interferon. Ribavirin / Copegus Rebetol is classified as an antiviral medication that works by preventing the virus in the human cells from multiplying in numbers, because of which existing virus stops producing additional viruses and thus clears the infection.

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[gandhimedicoshepc-blog]

Ribavirin is a synthetic drug with a pronounced antiviral effect. Ribavirin penetrates into virus-infected cells, blocks the formation of viral RNA, and thereby inhibits the multiplication of viruses. Ribavirin is highly active against herpes simplex virus type 1 and 2, cytomegalovirus , adenovirus, influenza A and B virus parainfluenza, hepatitis C virus, mumps, hemorrhagic fever, smallpox and some other viruses. Insensitive to the drug: the herpes zoster virus, smallpox, pseudorabies, enteroviruses, rhinoviruses. Ribavirin is well absorbed in the digestive tract; in the bloodstream penetrates into the erythrocytes, and in the respiratory organs - in the secret of the glands of the mucous membrane. With long-term use falls into the cerebrospinal fluid. The maximum concentration of this antiviral drug in the blood is noted 1.5 hours after admission. Plasma accumulates in large quantities. It is excreted from the body with urine very slowly (about 300 hours after cessation of administration).

[pushingarrows]

Ribavirin - a prodrug which metabolised to a guanosine analogue used to stop viral RNA synthesis and viral mRNA capping i.e. a nucleoside inhibitor for the treatment of hepatitis C, viral haemorrhagic fever, and RSV infection.

[tattooanniemae-blog]

Interferon