Rapid qualitative and quantitative HPLC/MS analysis of an antioxidant couple consisted of glutathione and ascorbic acid in a pharmaceutical product
Rapid qualitative and quantitative HPLC/MS analysis of an antioxidant couple consisted of glutathione and ascorbic acid in a pharmaceutical product
Image: wikimedia
Article published in the Journal of Pharmacy & Pharmacognosy Research 9(6): 803-812, 2021.
Stanislav V. Yefimov*
Pharmetric Laboratory, 11880 28th St N #210, 33716, St. Petersburg, FL, USA.
*E-mail: [email protected]
Context: In pharmacy products, glutathione and vitamin C are often present together. Both components not only enhance each other’s action but also…
Acid Uric 3× Tablet: Standardization and pharmacological evidence of uric acid use as anti-gout medicine
Acid Uric 3× Tablet: Standardization and pharmacological evidence of uric acid use as anti-gout medicine. @JPPRes
Image: WikimediaArticle published in the Journal of Pharmacy & Pharmacognosy Research 8(6): 501-514, 2020. Original Article Ayisha Shaukat*, Khalid Hussain, Nadeem Irfan Bukhari, Naureen Shehzadi
Punjab University College of Pharmacy, University of the Punjab, Allama Iqbal Campus Lahore-54000, Pakistan.*E-mail: [email protected], [email protected]
Rapid qualitative and quantitative HPLC/MS analysis of ethylenediaminetetraacetic acid in a pharmaceutical product without prior sample preparation
Rapid qualitative and quantitative HPLC/MS analysis of ethylenediaminetetraacetic acid in a pharmaceutical product without prior sample preparation @JPPRes
Image: Wikipedia Article published in Journal of Pharmacy & Pharmacognosy Research 8(4): 299-307, 2020. Stanislav V. Yefimov*
Pharmetric Laboratory, 11880 28th St N #210, 33716, St. Petersburg, FL, United States of America.*E-mail: [email protected]
Abstract
Context: Sodium calcium ethylenediaminetetraacetic acid (EDTA) is used to bind metal ions in the practice of…
A simple, precise and rapid RP-HPLC method has been developed
for the simultaneous determination of Proguanil and Atovaquone
in pharmaceutical dosage form.
Development and Validation of Stability Indicating Assay Method of Montelukast Tablet by RP-HPLC
by Miss. Harshada Ravindra Patil | Mr. Pavan Nathu Patil "Development and Validation of Stability Indicating Assay Method of Montelukast Tablet by RP-HPLC"
Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019,
Paper URL: https://www.ijtsrd.com/pharmacy/analytical-chemistry/29809/development-and-validation-of-stability-indicating-assay-method-of-montelukast-tablet-by-rp-hplc/miss-harshada-ravindra-patil
international journals in engineering, call for paper science, ugc list of journals
Background A simple, precise cost effective stability indicating assay method of Montelukast by RP HPLC. Material Chromatographic separation was achieved on a Meteoric core C18 column 100mm x 4.6 mm, 2.7µm using a mobile phase 2 ml Trifluroacetic acid mixture of acetonitrile 250ml and methanol 400ml 350 650 at a flow rate of 1.5ml per minute. Wavelength was detection at 255nm. The retention time of Montelukast was 4 minutes. Results The method was found linear concentration the range of 120.39 802.57µg ml, tablet analysis of RSD 0.403, accuracy range 30 , 50 , 100 , and 200 , Precision RSD 0.3. The proposed method was validated as per the ICH guidelines. Conclusion The HPLC method was validated and demonstrated good linearity, precision, accuracy, specificity, robustness and stability indicating. The development HPLC method can be utilized for routine analysis stability studies for Montelukast.
Paper URL: https://www.ijtsrd.com/pharmacy/analytical-chemistry/29703/rp-hplc-method-developed-for-the-estimation-of-etodolac-and-thiocolchicoside-in-bulk-and-combined-dosage-forms/prapulla-putta
ugc approved journals for social science, management journal, paper publication for engineering
A new, simple, specific, sensitive, rapid, accurate and precise RP HPLC method was developed for the estimation of Etodolac ETO and Thiocolchicoside THIO in bulk and combined pharmaceutical dosage forms. Etodolac ETO and Thiocolchicoside THIO was chromatographed on a Symmetry ODS C18 4.6mm—250mm, 5µm Column in a mobile phase consisting of Acetonitrile Methanol Acetate Buffer 25 20 55 v v. The mobile phase was pumped at a flow rate of 1.0 ml min with detection at 238 nm. The detector response was linear in the concentration of 200 600µg ml 20 60µg ml for Etodolac and Thiocolchicoside respectively. The intra and inter day variation was found to be less than 2 . The mean recovery of the drug from the solution was 99.98 . The developed method was validated for sensitivity, accuracy, precision, ruggedness and robustness. The RSD results for precision and intermediate precision found less than 2.0 . The LOD and LOQ were found to be 0.86 and 1.18 µg ml for Etodolac and 2.4 and 3.54µg ml for Thiocolchicoside respectively. The proposed method is simple, fast, accurate, precise and reproducible hence it can be applied for routine quality control analysis of Etodolac ETO and Thiocolchicoside THIO in bulk and combined pharmaceutical formulations.
Development and Validation of RP HPLC Method for Estimation of Vortioxetine in Bulk and Pharmaceutical Dosage Form
by Rathod K. G | Bargaje G. S | Rathod G. R | Deshpande O. V "Development and Validation of RP-HPLC Method for Estimation of Vortioxetine in Bulk and Pharmaceutical Dosage Form"
Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-6 , October 2019,
Paper URL: https://www.ijtsrd.com/pharmacy/analytical-chemistry/28040/development-and-validation-of-rp-hplc-method-for-estimation-of-vortioxetine-in-bulk-and-pharmaceutical-dosage-form/rathod-k-g
peer reviewed international journal, call for paper economics, ugc approved journals for chemistry
A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Vortioxetine in its pure form as well as in tablet dosage form. Chromatography was carried out on ODS C18 4.6 x 250 mm, 5µm column using Acetonitrile And Methonal 70 30 as the mobile phase at a flow rate of 1.0 mL min, the detection was carried out at 274nm. The retention time of the Vortioxetine was 2.922 ±0.02min. The method produce linear responses in the concentration range of 20 µg ml of Vortioxetine. The method precision for the determination of assay was below 2.0 RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.
A simple, precise and rapid RP-HPLC method has been developed
for the simultaneous determination of Proguanil and Atovaquone
in pharmaceutical dosage form.
