speaking of venom!steve (@findafight), I have a related pitch:
Science nerd supreme Dustin Henderson becomes spider man, and is subsequently forcibly adopted by Venom!Steve(+ Robin) and Deadpool!Eddie
Lonely jock Steve Harrington can't please his father, loses his job/girlfriend, accidentally fuses with symbiote!Robin. They're more than soulmates, they're two halves of the same whole. Together they're more than a little deranged and chocolate-obsessed, full of love and eager to bash assholes in the head with limbs shaped like spiked clubs.
Eddie can bounce back from a knife in his gut, a bullet in his brain, or, on one memorably unpleasant occasion, being literally eaten alive by mutant bats. But the one thing he can never manage is to fit in with the other heroes — so why try? He is a freak, and he's not going to hide it.
Dustin & his little superfriends think Venom is a monster when they first read Nancy's article about them in the Hawkins Post. But every time he encounters them, Venom seems more determined to manhandle Dustin out of harm's way than to fight with him. Before long, Dustin is pestering Venom to be his 'backup' whenever he's up against a powerful villain. Meanwhile, Dustin somehow finds himself helping Nancy's weirdo ex get back on his feet. Steve is a sweet guy despite everything, and Dustin hates to see him hurting.
The new mercenary on the block tells Dustin to call him Eddie about 5 minutes after they meet — if, by "meet," you mean "Eddie tracked him down, told him he thought dressing up like a giant spider was brave, then followed him around the city for an hour talking nonstop the whole time" (Dustin was suddenly intimately aware of what it was like for other people to be around him when he was caught up in one of his 'nerd rants,' as Steve called them). It turns out that Eddie is exactly Dustin's brand of crazy, and the two get along like a house on fire.
Now, if only Dustin could get his two favorite antiheroes to get along as well...
Eddie has no secret identity, but it takes Dustin a little while to figure out Steve's (there's a period where he thinks Steve has a secret girlfriend named Robin). At one point in that period, Dustin introduces Steve to Eddie as civilians (under duress — Eddie is being hunted down, and Steve's apartment is a safe place to lay low), and the resulting situation is... awkward.
Steve&Robin don't trust Eddie with Dustin. They don't know him well but they know he's reckless and likes to tempt danger — just like Dustin, but supercharged. But they're not going to turn him away when he needs help, not when they know what he means to Dustin. And besides, it would be hypocritical of them to judge him for being alleged murderer, when they definitely bit the heads off a few bad guys back when they were still figuring things out.
Eddie is a storyteller by nature, of course he knows he's living a superhero comic. But that doesn't mean he knows everything. Eddie thinks Venom is boring, too serious, another alien monster just like all the others that visit Earth to brawl with its defenders seemingly every other Tuesday. Where's the complexity, the intrigue, the motive?? Steve on the other hand... Steve is a mystery, a truly bizarre character underneath his plain, archetypal exterior, and Eddie is determined to figure him out.