SLC45A2 - Solute Carrier Family 45 Member 2
This gene encodes a transporter protein that mediates melanin synthesis. The protein is expressed in a high percentage of melanoma cell lines. Mutations in this gene are a cause of oculocutaneous albinism type 4, and polymorphisms in this gene are associated with variations in skin and hair color.
Japanese medaka
albinism
Inheritence: recessive.
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Northern snakehead
yellow-albino
Inheritence: recessive.
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Chicken
silver (two mutations)
imperfect albinism
Inheritence: silver is sex-linked dominant, imperfect albinism is sex-linked recessive.
silver, silver and imperfect albino
Japanese quail
cinnamon
imperfect albinism
Inheritence: sex-linked, order of dominancy is wild type>cinnamon>imperfect albino.
cinnamon, cinnamon and imperfect albino
Alexandrine parakeet
lutino (two mutations)
Inheritence: sex-linked recessive.
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Rose-ringed parakeet
lutino
Inheritence: sex-linked recessive.
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Plum-headed parakeet
lutino
Inheritence: sex-linked recessive.
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Mouse
dominant brown
dense
underwhite (five mutations including blanc sale)
Inheritence: dominant brown is intermediate, the rest are recessives.
heterozygous (back) and homozygous (front) dominant brown, homozygous dense (foreground), homozygous underwhite (front)
Dog
albinism (three mutations)
Inheritence: recessive.
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Tiger
white
Inheritence: recessive.
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Sheep
Suffolk white fleece
Inheritence: probably recessive.
white-fleeced lamb with black-fleeced mother, white-fleeced adult
Cattle
chocolate/cream dilution
albinism (two mutations)
Inheritence: both recessive to the wild type, interaction unknown.
chocolate, albino
Horse
cream
pearl
sunshine
snowdrop
Inheritence: cream is intermediate, pearl, sunshine and snowdrop are recessives, their compound heterozygote look like cream homozygotes.
buckskin (Cr/N), perlino (Cr/Cr), pearl (prl/prl), pseudo-double dilute (Cr/prl), pseudo-double dilute (Cr/sun), snowdrop (sno/sno)
Donkey
cream
Inheritence: recessive.
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Western gorilla
albinism
Inheritence: recessive.
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