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Memahami Tentang Growth Hacking dan Cara Melakukannya

Memahami Tentang Growth Hacking dan Cara Melakukannya

TECHSTORY.ID, SURABAYA – Pernakah anda mendengar atau membaca tentang Growth Hacking ? Belakangan ini, sering kita jumpai istilah Growth Hacking dalam dunia startup maupun marketing. Apakah sebenarnya Growth Hacking itu? Berikut penjelasan selengkapnya:

Pengertian Growth Hacking 

Growth Hacking merupakan teknik marketingyang dikembangkan startup melalui kreativitas, analisa dan data sosial media…

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Dilshad Ahmad Khan and his team member Faiz Iqbal, Zafar Alam won the Appreciation award for the project Design & Development of Automated Five Axis CNC Ball End Magnetorheological Finishing Machine. He carried his project work under the guidance of Dr. Sunil Jha, Indian Institute of Technology, Delhi.

The project is an innovation and technology based work aimed at providing nano level finish on various materials of complex shapes and size. This project is related to the design and development of a fully automated five axis CNC ball end magnetorheological finishing (BEMRF) setup from the conceptual idea to an industry standard machine. The developed machine caters to the demand of today's advanced industries which deals in finishing of 3-D dies, high precision lenses, orthopaedic implants, jewelleries and gems etc. In the first phase of the project an idea is conceptualized to finish 3-D complex surfaces using magnetorheological polishing (MRP) fluid. After checking the feasibility of the concept, a BEMRF tool is developed which is later mounted on a CNC machine setup. The newly developed finishing process is used to finish ferromagnetic as well as nonmagnetic materials of complex shapes and sizes using specially prepared magnetorheological polishing fluid. Apart from nano finishing on the surfaces, the measurement of surface roughness of the workpiece is also needed to be wear free which is not the case in stylus based measurement systems. Therefore, a non-contact roughness measurement instrument (confocal sensor) is incorporated in BEMRF machine. The confocal sensor is light, compact and easily mounted on the BEMRF tool for quick and error free measurement of surface roughness after the BEMRF process. In BEMRF machine the forces can be controlled automatically thereby enabling the user to select suitable force according to the material to be finished.

Anil Sahasrabudhe, Chairman of the All India Council for Technical Education, honored Dilshad Ahmad Khan, research scholar, Indian Institute of Technology, Delhi, with the prestigious Gandhian Young Technological Innovation (GYTI) Appreciation award 2017  at Rashtrapati Bhavan.

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Students of the Indian Institute of Science, Bangalore Dhiraj Indana including his team member S.C.G. Kiruba Daniel, Varun S, Prateek Katare who worked under the guidance of Dr. Sai Siva Gorthi received the Gandhian Young Technological Innovation Award-2017 for developing a prototype of a Low Cost Automated Handheld Melamine Detection Device (for Testing Melamine in Milk).

Even though a number of kits and devices are available for detecting common milk adulterants like urea, boric acid, water, sugar and detergents, there is hardly any portable device available for the detection of melamine. Till now, bulky instruments like Gas Chromatography (GC), HPLC, GC-MS and LC-MS are being used for detecting melamine which costs between 25 to 50 lakhs rupees, as well as requiring skilled personnel for operation. A fully automated handheld device to detect melamine from milk with integrated milk pre-processing step done using chemical dried cotton is developed. Melamine is finally detected through interference in Silver nanoparticle formation. Both the preprocessing and detection steps are innovative and patented. The cost of the device may be few thousand rupees which is almost 1000 times lesser than the price of existing conventional instruments. The developed device is user-friendly Low Cost Automated Handheld Melamine Detection Device (for Testing Melamine in Milk) which can give the level of melamine adulteration in ppm directly. Thus, the device not only tells the user whether the milk is fit for consumption or not but also gives the exact concentration of melamine in milk. This device fulfills the goal of taking melamine sensing to every household so as to protect every person from melamine adulteration.

For this innovation Dr. R A Mashelkar, Chairperson, Research Advisory Committee, SRISTI and NIF, honored Dhiraj Indana, Department of Nano Science and Engineering, Indian Institute of Science, Bangalore, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at a function held at Rashtrapati Bhawan on March 5.

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K. Rajasekhar and Kavita Shah received the award for the research project Near Infrared Fluorescence Probes for Diagnosis of Alzheimer's disease. He carried his research work under the guidance of Prof. T. Govindaraju, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru at a function held at Rashtrapati Bhawan on March 5.

Selective detection and staining of toxic amyloid beta (Aβ) plaques found in the Alzheimer's disease (AD) brain is crucial for clinical diagnosis and monitoring of the disease progress. Herein, a coumarin-quinoline (CQ) conjugate-based molecular rotor type, turn-on near-infrared (NIR) fluorescence probe for selective and specific detection of Aβ fibrillar aggregates is designed. The probe CQ selectively binds to Aβ fibrillar aggregates over other toxic protein aggregates such as Tau, α-synuclein (α-Syn) and islet amyloid polypeptide (IAPP), and exhibit ~100 fold fluorescence enhancement with nanomolar binding affinity (82 nM). CQ effectively displace Thioflavin T bound to Aβ fibrillar aggregates and exhibit multiple binding sites on Aβ fibrillar aggregates which is extensively studied through fluorescence resonance energy transfer (FRET) and molecular docking. Remarkably, CQ unambiguously stains Aβ plaques in human brain tissue over its co-existing Tau aggregates, neurofibrillary tangles (NFTs), which are strongly associated in AD and in various tauopathies. This is a highly desirable attribute to distinguish AD from disease conditions caused by Tau pathology.

Dr. Francis Gurry Director General of the World Intellectual Property Organization (WIPO) honored K. Rajasekhar, Department Biological Sciences, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan.​

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Subham Banerjee won the award for the research project Prophylactic Transdermal Patch Against Neurotoxin Poisoning In Biological Warfare Situations. He carried her research work under the guidance of Dr. Pronobesh Chattopadhyay, Dr. Animesh Ghosh Defence Research Laboratory, Tezpur Birla Institute of Technology, Mesra.

Drug-in-adhesive matrix type combinational prophylactic transdermal patch composed of eserine and pralidoxime chloride (PAM) against acetyl choline agonist (±)-anatoxin a neurotoxin poisoning was developed. Initially, a simple RPHPLC method was developed and validated for the s imult aneous de t e rmina tion and quantification of eserine and 2-PAM using UV detection. The method was validated as per ICH guidelines for validation of analytical procedures, and was applied for the routine analysis of these two drugs in fabricated transdermal patches.

Adhesive matrix type transdermal patches containing eserine and 2-PAM were prepared by solvent casting method. The drug combinations were incorporated in adhesive matrix type system supported by a polyester film laminate backing membrane and attached to a temporary releaseliner. The dermal patches were having desired properties such as thin, circular, opaque, smooth, homogeneous, sticky, uniform, flat and flexible in nature. The drug release was sustained from all the formulations up to 72 h and following anomalous (non-fickian) diffusion and fickian release mechanism for eserine and 2-PAM, respectively. Optimized transdermal patch exhibited highest acceptable levels of tackiness with good adherence capacity and showed promising stability potential with respect to all points of analysis. From safety point of view, the optimized transdermal patch was safe for application to the skin with no dermal and mutagenic toxicity as well. Pharmacodynamic study proved that the optimized transdermal patch was effective against acetyl choline agonist (±)-anatoxin a neurotoxin poisoning. While pharmacokinetic study revealed that the systemic absorption of the drugs from the fabricated best optimized patch through the skin was sufficient enough to achieve pharmacodynamic efficacy.

Dr. Prof. K. Vijay Raghavan Secretary, Department of Biotechnology honored Subham Banerjee, Defence Research Laboratory, Tezpur Birla Institute of Technology, Mesra, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan.

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Saugandha Das including her team member Archit Devarajan won the award for the research project STERI-FREEZ: Flash Freeze Sterilization. She carried her research work under the guidance of Prof. Padma V. Devarajan Institute of Chemical Technology, Mumbai.

Surgical site infections are one of the most common complications associated with surgery, with reported incidence rates of 2-20%. The problem is enhanced in rural or under-resourced clinics in under-developed or developing countries with about one-third of surgical patients getting infected, a rate which is nine times greater than in developed countries. Of the various causes, the use of contaminated medical instruments that have not been properly cleaned and sterilized directly contribute to surgical site infections with around 20 million post-operative patients infected. In absence of proper sterilization and disinfection protocols or methods these situations may become life threatening. Rural clinics in developing countries cater to 3 billion people worldwide, but do not have minimum provisions necessary to prevent post-surgical infections. Considering India has over 60% of the population living in villages, this is a serious problem and hence needs great attention.

Thus STERI-FREEZ provides an AMAZINGLY SIMPLE on-site technology, which provides a ready to use, economic yet effective solution to the existing lacuna. This portable, cold sterilization device comprises of an insulator box housing a metallic vessel covered with a lid containing a green cryogenic biocidal mixture or Flash Freeze Elixir (FFE). Sterilization is achieved using a combination of biocides acting at subzero temperatures (-70 degree Celsius). Surgical instruments to be sterilized are kept immersed in FFE and removed just prior to use without leaving any toxic residue on the surfaces. Conventional methods of medical sterilization (autoclave, hot air, chemical and gaseous sterilization) require energy intensive instruments and long processing time while alternative sterilization techniques (Boiling in water) are not considered effective enough.

Dr. Renu Swarup Senior Advisor, DBT and MD, BIRAC honored Saugandha Das, research scholar, Department of Medical Science & Technology, Institute of Chemical Technology, Mumbai and Archit Devarajan, research scholar, Department of Medical Science & Technology, Ramnarain Ruia college, Mumbai with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan.

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Sonali Singh Doharey including her team member Rahul Pratap Singh, Poornima Agrawal won the award for the research project Targeted Theranostic Nanomedicines for Brain Cancer Therapy. She carried her research work under the guidance of Dr. M. S. Muthu, Prof. B. L. Pandey Banaras Hindu University, Varanasi.

Brain cancer is considered as one of the most devastating diseases because it is hard to treat and cure. Chemotherapy is the most common method for the treatment of different types of brain cancers. Unfortunately, the diagnosis and therapy of brain cancer are very unsatisfying because of the existence of the blood-brain barrier (BBB), which excludes more than 98% of small molecules and almost 100% of large molecules. Another obstacle in cancer therapy is to maintain the desired concentration of therapeutic agents and/or diagnostic agents at tumor site.

The innovator developed targeted and controlled release nanomedicine systems including transferrin conjugated D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) micelles and transferrin / arginine – glycine – aspartic acid (RGD) conjugated TPGS liposomes (i.e., transferrin conjugated liposomes and RGD conjugated liposomes) to deliver docetaxel (DTX) and quantum dots (QDs), simultaneously through receptor-mediated active delivery for brain cancer therapy. Innovator demonstrated that RGD or transferrin TPGS decorated theranostic liposomes were highly effective in delivering desired concentration of therapeutic agents and diagnostic agents across BBB without any signs of brain damage or edema in brain histopathology. These advanced platforms can diagnose brain cancer at early stages, initiate first-line therapy, monitor it, and if needed, rapidly start subsequent treatments. In future, brain theranostics will be able to provide personalized treatment which can make brain cancer even curable or at least treatable at the earliest stage.

Prof. Anil K Gupta, Co-ordinator, SRISTI and Founder, Honey Bee Network honored Sonali Singh Doharey, and her team, Department of Pharmacy, Banaras Hindu University, Varanasi, with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017 at Rashtrapati Bhavan.

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Shivangi Sachdeva and Narendar Kolimi won the award for the research project Revealed: Dual Functional Characteristics of Escherichia Coli Outer Membrane Protein Wzi And Its Implications In The Design Of Novel Antibiotics. she carried her research work under the guidance of Dr Thenmalarchelvi Rathinavelan, Indian Institutes of Technology, Hyderabad. 

The emergence of multidrug resistance in bacteria is a major cause of infection and mortality worldwide. In Gram-negative bacteria, polysaccharide layers are one of the major virulent determinants that are involved in the evasion of host immune response as well as offers impermeability to antibiotics. Thus, inhibiting the capsular polysaccharide (CPS) biogenesis or surface exportation or its attachment to the bacterial surface may be an attractive strategy to generate avirulent Gram-negative bacterial strains. Here, the focus is on multidrug resistant Gram-negative Escherichia coli (E. coli), which is a common cause for urinary tract infections (including infections in the kidney), bloodstream infection, intra-abdominal infections such as peritonitis, skin and soft tissue infections, neonatal meningitis, diarrhea and food borne infections.

An E.coli outer membrane protein Wzi that acts as an anchor for CPS onto the bacterial surface (viz., a lectin) also exhibits a bidirectional passive water conduction property (viz., a porin). Such a dual functional role of Wzi was not realized earlier due to the occluded pore, a property that can be used to treat E. coli infections. It is observed that three water specific entry points across extracellular face regulate the water diffusion involving different mechanisms and a luminal hydrophobic plug governs water permeation across the channel. Thus, a drug molecule that can either interfere with the water conduction by Wzi or the attachment of CPS to Wzi may aid in reducing the bacterial virulence and make them susceptible to antibiotics or host immune response

Dr. R A Mashelkar, Chairperson, Research Advisory Committee, SRISTI and NIF, honored Shivangi Sachdeva, Narendar Kolimi, research scholar, , with the prestigious BIRAC-SRISTI Gandhian Young Technological Innovation (GYTI) Award 2017  at Rashtrapati Bhavan.