Jinendra Kapoor - aka Chhaaya - A member of the Rising Tide from India, now studying in Massachusetts, Chhaaya has some fairly strong political opinions and the skills to harass bullies.
Enoch - A sentient anthropological study android from the constellation Cygnus, Enoch is over thirty thousand years old. Sworn never to interfere, only to observe, this hasn't stopped him from stepping in to help SHIELD prevent an extinction-level catastrophe.
Lady Margaret Fairbairn - The daughter of Lord Leonard Fairbairn and his wife Frances, Maggie helps coordinate the family's charity events and organizes the housing of war-evacuee children from London.
Persephone Fitz - Framework-exclusive character - The daughter of Dr. Leopold Fitz and a crippled Madame Hydra, Persephone was born to lead Hydra. Her parents never fed her with a silver spoon, though, and she has had to earn her rank the same as they did, from the bottom up.
Freya Fitzsimmons - coordinates with @unaugmentedmonkeyscantfly‘s Cut Off the Head AU - The daughter of FitzSimmons, Freya is inquisitive, playful, a little overbearing, and prone to dreams of alternate timelines. She loves her family, and she loves to cook.
Susan Fitzsimmons - coordinates with @unaugmentedmonkeyscantfly and @jemmaqueenofspace‘s An Unearthly Child AU - Raised by a queerplatonic FitzSimmons after she was found at the site of the fear rift, Susan uses her unique alien empathic powers as a therapy aid.
H.E.N.R.Y. - 616-inspired - An artificial AI built by Fitz that didn't get out of the alpha testing stage, HENRY was designed to run diagnostics with his little holographic monkey hands.
Hotaru Imomoto - Okinawa-raised Hotaru is a brilliant SHIELD roboticist who vastly prefers work as a file clerk. After the destruction of the Triskelion, he fled back to his home to reflect on his life choices and to hide from Hydra.
Jessica Jones - A New York City PI who drinks as much as she swears, Jessica has never wanted to be a hero. Or a good samaritan. Hell, she doesn't even aspire to be a people person. Somehow she manages the first two.
Agnes Kitsworth - Agnes has the soul, eye, and hand of an artist, but her time in this world is limited. An inoperable brain tumor is constantly looming, forcing Agnes to live every day as if it were her last.
SHIELD Director Jeffrey Mace - aka The Patriot - The whole world thinks he's an Inhuman, but that's not true. He's just a man in a sticky postion, trying to do the best he can for SHIELD and for the planet.
M’Ziwa - A Wakandan sorceress who decided to see the wisdom of other cultures when the Ancient One's teachings did not prevent or allow revenge for the murder of king T'Chaka.
Danny Rand - aka The Immortal Iron Fist - Orphaned at age ten when his family's private jet crashed in the Himalayas, Danny was raised by the warrior monks of K'un-Lun. He trained to become the Iron Fist, sworn enemy of the Hand, and now, he's returned to NYC.
Benjamin Rice - A young Inhuman boy who was disowned by his parents when they discovered his ability to phase-shift and teleport from place to place. Now he lives at a home for similar displaced Inhuman kids.
Agent Lilian Smythe - Somewhere between Ops and Comms, the half-French agent was holding down the Cube during the Hydra takeover and is only just now coordinating with the Director and his team.
Agent Jeremiah Warrick - 616-inspired - A SHIELD agent dedicated to cataloguing magical tomes, sometimes he accidentally reads the spells aloud and ends up with...interesting results.
Monarch Xzera - The androgynous monarch and sorcerer supreme of the alien world Eldrixia, zhe heard of the death of the Ancient One and decided to check up on Earth to see if it's safe.
Cal Zabo - aka Kyle Winslow in current-set threads - Cal Zabo was written over, and in his place is Kyle Winslow, a mostly mild-mannered veterenarian with a past that's not as coherent as he'd like. A strong champion of animal welfare and a harsh critic of abuse, Kyle still feels like there's something missing from his life, something wrongly taken.