#transgene

[alexandriachris69]

Lets be friends DM 🥰😍😘

Lets be friends DM😍🥰😘

[ninapinkova]

Hey everyone! Do you like black sheers, silver and heels?

This is a set reveals quite a lot about me and I was really shy to go this way before, but now you can see it all on my patreon account. If interested. :) 

Thank You for following me here on tumblr! 

By the way, I really appreciate your reblogs, likes and any help I got thanks to you. Also I hope you understand that not every one is in a good situation right now and any support would help me get through the these harsh times of transition. I won’t say more, if you want to help and become my supporter you can here:  www.patreon.com/ninapinkova

Have a beautiful week!

Your Nina

[bpod-bpod]

Super Worm

Panther worms (Hofstenia miamia) are used to horrific injury – they will happily take bites out of each other when hungry. It’s all part of life for an animal that can regenerate its entire body. H.miamia can regrow its tail, its muscles, even its brain. In fact, if you chopped it to bits, new worms would grow from the pieces. Here researchers use genomic engineering to make its embryonic stem cells transgenic – introducing genes that produce green and red fluorescent proteins and highlighting different tissues in the developing worm. Under a confocal microscope, researchers spot growing muscle acting as a sort of scaffold for the developing skin (red) to crawl up. With these techniques in hand, one next step is to investigate how the worm regenerates completely – perhaps finding similarities in human stem cells that could be guided to heal wounds.

Written by John Ankers

Image by Lorenzo Ricci, Srivastava Lab

Department of Organismic and Evolutionary Biology, Museum of Comparative Zoology, Harvard University, Cambridge, MA, USA

Image copyright held by the original authors

Published in Developmental Cell, November 2021

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[btcmanager]

French Pharma Firm Transgene Utilizes Blockchain to Track Clinical Trials

French Pharma Firm Transgene Utilizes Blockchain to Track Clinical Trials

In a recent press release, French biopharmaceutical firm Transgene announced its integration with blockchain supply chain traceability solution Hypertrust-X Chain for Clinical Trials for its individualized therapeutic vaccine against ovarian, head, and neck cancer to provide an immutable audit trail throughout the treatment process. Hypertrust X-Chain to Track Clinical Trials In a bid to leverageRead More

https://btcmanager.com/french-pharma-firm-transgene-blockchain-track-clinical-trials/?utm_source=Tumblr&utm_medium=socialpush&utm_campaign=SNAP

[en24news]

TRANSGENE and INNATE PHARMA in turmoil

TRANSGENE and INNATE PHARMA in turmoil

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Published on 12/13/2019 at 12:30 pm

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[phil-iannaccone]

Replay!

July 29th, 2016:

Stem cells can give rise to many types of cells that are necessary for a normal organ to function properly. These cells can be grown in a dish essentially indefinitely. This gives rise to the hope that scientists specializing in regenerative medicine can learn how to repair or replace damaged organs like kidneys or bladders in children or adults. Stem cells were discovered and isolated from very early embryos but required the destruction of the embryo. In humans this was ethically unacceptable for many.

By Lars Frantzen (Own work) [CC BY-SA 3.0 (http://creativecommons.org/licenses/by-sa/3.0)], via Wikimedia Commons

More than ten years ago Japanese scientists discovered a way to take any adult cell, like a skin cell or a fibroblast and turn it into a stem cell. NO embryo NO ethical dilemma! The process required inserting genes with special properties into the adult cell. Because these genes are inserted into the cell from outside they are called transgenes. The good news is that the process is robust and can be used from a patient’s own cells. The bad news is that some of the genes inserted can cause cancer. But, the transgenes are turned off as part of the process of turning the stem cells into the desired cell type. They are said to be silenced.

Replay! from Galat et al. 2016. Cells with re-activated transgene appear red or green.

Transgene silencing in these induced stem cells (they are called induced pluripotent stem cells or iPSC for short) is generally accepted as a fact. Scientists at the SMCRI recently discovered that this article of faith might not be completely justified. In a surprising report just published they demonstrate that the silenced transgenes can turn back on. The result is that cells that were well on their way to becoming useful differentiated cells (cells of a desired type and with desired functions) revert to stem cell status and once again behave as pluripotent (capable of making many different cell types).

These findings are surprising and while the phenomenon may be unusual it provides a cautionary tale for scientists working with these cells. They may need to rethink results of some experiments and the re-emergence of stem cell properties may pose a risk of cancer when the cells are used. Newer methods are being developed that result in the elimination of the transgene right at the beginning of the process. In principal this should prevent the transgenes from getting turned on again because they are not there. However, it may not be that simple and this needs to verified in light of this new discovery.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.

[biological-chemistry]

After the pSB999 (above is a similar pBR322) plasmid has been taken into the cell, the expression of ampicillin resistance is not instantaneous. The coding region ampR must undergo transcription into mRNA which must then be translated. Translation is the biosynthesis of proteins from mRNA. The expression of ampR results in an empirical phenotype, ampicillin resistance. 

[virusdelahepatitisc]

15-05-2012

"Algunos casos de trombocitopenia y uno de aplasia medular podrían comprometer su desarrollo"

Un estudio presentado en el 47 Encuentro Anual de la Asociación Europea para el Estudio del Hígado (EASL 2012), celebrado recientemente en Barcelona (España), ha mostrado buenos resultados de una vacuna terapéutica en investigación contra el virus de la hepatitis C (VHC).

La vacuna terapéutica, conocida como TG4040 y propiedad de la compañía francesa Transgene, ha sido diseñada para estimular el sistema inmunitario contra el VHC al combinarse con interferón pegilado. TG4040 está basada en un vector MVA (vacuna de Ankara modificada, en sus siglas en inglés) que contiene secuencias que codifican las proteínas NS3, NS4 y NS5B del VHC de genotipo 1b.  El presente estudio, de fase IIb y abierto, incluyó a 153 personas monoinfectadas por VHC de genotipo 1, de las cuales el 80% presentaban el subtipo 1b. La mayoría de voluntarios eran hombres de etnia blanca y la edad media era de 43 años...