HIPs can play a major role in the pathogenesis of T1D
http://www.cusabio.com/ELISA-Kit/Guinea-pig-dopamineDA-ELISA-kit-1035515.html
A new study suggests that I diabetes (T1D) may be associated with insulin-related peptide. These peptides incorrectly combine with other peptides inside the spleen and pancreas. These findings could help explain the mystery of why T1D patient's immune system attacks the insulin-producing cells.
More recently, some evidences have begun to explore the roles that the peptides (which are short-chain amino acids used by the cells used for the various processes) may play. Thomas Delong, who previously discovered a kind of antigen and a related peptide WE14 - it can trigger an autoimmune response against the insulin-producing β- cells in the body of the mice which suffer from T1D trigger. However, it can't explain autoimmune response seen in T1D only by WE14. This allows the researchers to speculate on whether there is a combination of covalent binding peptides (which is called mixed insulin peptide, HIPs) that triggers the reaction. They created two peptide libraries and cross-reference them and found a number of provocative peptides associated with WE14. The frequency rate of the peptides being found in the mouse pancreas (which produce insulin organ) shows a significant increase. Furthermore, these hybrid peptides are clearly easier to be recognized by T cells than individual peptides. The researchers then explored whether human T cells can recognize these HIPs. The analysis of samples donated by two T1D patients revealed that they have a number of T cells capable of specifically take these HIPs as the target.
Therefore, the researchers propose that HIPs can play a major role in the pathogenesis of T1D by making the immune system attack the insulin-producing β cells.
