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1000kg pure lithium orotate powder cas 5266-20-6 In Stock

Lithium orotate powder is white powder, CAS number 5266-20-6, it is the main ingredient use for lithium orotate supplements.

Lithium orotate intervention demonstrated benefit in treating alcoholism, and was also associated with improvements in migraines and depression. Sartori 1986 Other studies show lithium orotate may reduce the frequency and severity of migraine attacks and improve depression associated with bipolar disorder.

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Powder Spermine Vs Spermidine trihydrochloride: are they the same?

Spermine Raw Material 71-44-3 General Description

Spermine is an endogenous polyamine bearing multiple amino groups. It has been found to play important roles in cellular metabolism in all eukaryotic cells. It also can condense DNA in sperm due to its positive charge in the physiological condition. Because spermine is an endogenous molecule widely present in the biological environment, it is expected that spermine will have better biocompatibility then other synthetic cationic molecules.

Spermine raw material include spermine free base CAS 71-44-3 and spermine tetrahyddrochloride powder CAS 306-67-2. Spermine free base is liquid form, spermine tetrahyddrochloride is raw powder form.

Spermine Raw Material 71-44-3 History

Antonie van Leeuwenhoek first described crystals of spermine phosphate in human semen in 1678. The name spermin was first used by the German chemists Ladenburg and Abel in 1888, and the correct structure of spermine was not finally established until 1926, simultaneously in England (by Dudley, Rosenheim, and Starling) and Germany (by Wrede et al.).Spermine is the chemical primarily responsible for the characteristic odor of semen.

Spermine Raw Material 71-44-3 Mechanism Of Action

Spermine is derived from spermidine by spermine synthase. Spermine is a polyamine, a small organic cations that is absolutely required for eukaryotic cell growth. Spermine, is normally found in millimolar concentrations in the nucleus. Spermine functions directly as a free radical scavenger, and forms a variety of adducts that prevent oxidative damage to DNA. Oxidative damage to DNA by reactive oxygen species is a continual problem that cells must guard against to survive. Hence, spermine is a major natural intracellular compound capable of protecting DNA from free radical attack. Spermine is also implicated in the regulation of gene expression, the stabilization of chromatin, and the prevention of endonuclease-mediated DNA fragmentation.

Spermine Raw Material 71-44-3 Application

Spermine is an endogenous polyamine bearing multiple amino groups. It has been found to play important roles in cellular metabolism in all eukaryotic cells. It also can condense DNA in sperm due to its positive charge in the physiological condition.

Spermine is commonly used in molecular biology and biochemistry research. The polycationic character of spermine in solution allows for its use in the precipitation of DNA of >100 base pairs in length from low salt aqueous buffers, and for the isolation of DNA from pulse field gels.Spermine has also been utilized in chromosome isolation and in the aggregation of chromatin. It may be used as a

building block for the preparation of gene transfer agents.The complexation of spermine with DNA to form particles with diameter <100 nm has been studied. Spermine has been used in the crystallization of DNA.

Spermine Vs Spermidine

Spermine is not the same as spermidine. Spermine is formed through the addition of a aminopropyl group to spermidine by spermine synthase. Spermine is strongly basic in character, and in aqueous solution at physiological pH, all of its amino groups will be positively charged.

Good dietary sources of spermidine are aged cheese, mushrooms, soy products, legumes, corn, and whole grains. Spermidine is plentiful in a Mediterranean diet. For comparison: The spermidine content in human seminal plasma varies between approx. 15 and 50 mg/L (mean 31 mg/L).

What foods are high in spermidine?

Spermidine is found in fresh green pepper, wheat germ, cauliflower, broccoli, mushrooms, and a variety of cheeses. Even higher amounts are found in soybean products such as natto, shitake mushrooms, amaranth grain and durian.

Where is spermine found?

Spermine is a polyamine, a small organic cations that is absolutely required for eukaryotic cell growth. Spermine, is normally found in millimolar concentrations in the nucleus. Spermine functions directly as a free radical scavenger, and forms a variety of adducts that prevent oxidative damage to DNA.

Spermine Raw Material 71-44-3 Reference

Dudley, H. W; Rosenheim, O; Starling, W. W (1926). “The Chemical Constitution of Spermine: Structure and Synthesis”. Biochemical Journal. 20 (5): 1082–1094. doi:10.1042/bj0201082. PMC 1251823. PMID 16743746.

Xie, X., et al., Coiled-coil packing in spermineinduced tropomyosin crystals. A comparative study of three forms. J. Mol. Biol., 236(4), 1212-1226 (1994).

Wrede, F (2009). “Ueber die aus dem menschlichen Sperma isolierte Base Spermin”. Deutsche Medizinische Wochenschrift. 51: 24. doi:10.1055/s-0028-1136345

Lewenhoeck, D. A (1677). “Observationes D. Anthonii Lewenhoeck, De Natis E Semine Genitali Animalculis”. Philosophical Transactions of the Royal Society of London. 12 (133–142): 1040–1046. Bibcode:1677RSPT…12.1040A. doi:10.1098/rstl.1677.0068.

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Olivetol Powder and CBD synthesis

A review of CBD synthesis has been reported some years ago (Mechoulam & Hanuš, 2002). CBD is conventionally prepared from olivetol, a resorcinol bearing a pentyl side chain. Olivetol powder was also used as an inhibitor of (S)-mephenytoin 4′-hydroxylase activity of recombinant CYP2C19.

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Buy Spermidine trihydrochloride Powder 98% Antioxidant Supplement Factory

Spermidine Powder: Is It Worth the Hype?

The human body is made up of organs and tissues, which in turn are composed of functional units of the body, namely cells. Almost every biological process is performed and maintained at the cellular level, and the results of these are projected onto the tissues and organs. Starting with stem cells, human cells throughout the development process during the embryological period differentiate into different cells that migrate to different parts of the body and perform different functions accordingly.

The cells perform various functions such as metabolism and homeostasis, however, they are incapable of doing so on their own and need different chemicals, enzymes, and signaling compounds to help them achieve the desired results.

The different types of cells have a different life span and once they have completed that period, they enter senescence or old age, of sorts, after which they are broken down or degraded, marking the end of their life.

As one ages, the cellular functions get altered first, resulting in the physical symptoms of aging, eventually. However, multiple types of research have been performed to study and understand how to increase the lifespan of the cells and consequentially, humans. As a result of these studies, a longevity agent was discovered which also happens to be one of the main compounds that are crucial for the maintenance of the different functions of the cells. This compound is found in abundance in the human body and is named spermidine.

Improving human health and promoting the increased life span of the cells, and consequently, the human, is the main function of this compound, although it takes part in various chemical and metabolic reactions in the body.

What is Spermidine Powder?

Spermidine is a naturally found polyamine that is important for the normal functioning of the entire body. Although it doesn’t exactly play a role in the maintenance or production of sperm, it is called the spermidine compound because it was initially discovered in semen. It is synthesized in the human body through the actions of the enzyme, spermidine synthase on the compound, putrescine.

Spermidine can be further broken down into spermine, and other polyamines, including the structural isomer of spermine, thermospermine. Found in the ribosomes of the cell, the main function of this compound is to promote autophagy which allows cell renewal to take place in the human body. It is able to perform these functions by inducing autophagy at a cellular level in the body, rather than at superficial levels.

Given the huge role spermidine plays in the body, managing normal levels of it must be important. However, it was discovered that Spermidine levels in the body begin to decrease as one ages, which can decrease the efficiency with which the different metabolic functions are being performed. All of this results in the decreased capabilities of the human body which are normally blamed on aging, but it isn’t aging directly that causes it but rather the result of degradation of crucial compounds in the human body.

Spermidine powder is a supplemental exogenous form of Spermidine that aims to replenish the body’s stores of this aliphatic polyamine and enhance the functioning of the body.

History of Spermidine

Spermidine is named such because it was initially isolated from semen but since then it has been discovered that it is widely distributed in the human body and plays different roles in different parts of the body. Although it is important to note that it has one main function throughout the body which is cell proliferation and renewal, by promoting autophagy. It is one of the main longevity agents in humans and other mammals.

The longevity agent was initially discovered in the human semen by Antoni van Leeuwenhoek, in 1678 although he described it simply as crystals. It wasn’t until almost 200 years later that it was discovered that the crystals seen by Leeuwenhoek were spermine, a successor of Spermidine. However, the chemical structure of spermidine and spermine was still not known and it wasn’t until 1924 that the chemical structure was discovered and studied in detail.

Further studying of spermidine’s structure revealed more about its functions and specific features in the human body. It was found that spermidine, like every other polyamine, is a stable compound that does not dissolve or react in acidic or basic environments. Moreover, spermidine was found to have a positive charge that allows it to bind to negatively charged molecules such as RNA and DNA.

Furthermore, Spermidine was found to be available in abundance in the human body, with the levels beginning to decrease as one age, around the same time collagen and elastin levels being to decrease as well. During the early phase of life, humans receive spermidine through breast milk or baby formula and as they grow old, they receive spermidine from different food sources. However, natural exogenous sources of spermidine are not enough to replenish the stores of the compound that are being emptied due to decreased production of the polyamine.

In such cases, several kinds of research were performed to analyze how the stores can be replenished and Spermine supplements containing Spermidine trihydrochloride powder as an active ingredient were found to be the solution to this problem. Spermidine supplements are now readily available and are widely accepted as longevity supplements.

The function of Spermidine in the Human Body

Spermidine supplements play the same roles as spermidine would in the body which is why it is important to know the key functions of Spermidine in the human body. Spermidine is found to be crucial for the inhibition of neuronal nitric oxide synthase or nNOS, that as the name suggests is only expressed in the peripheral and central neurons. The main function of nNOS is to monitor and regulate the vasomotor tone and regulate central blood pressure along with maintenance of synaptic plasticity in the central neurons.

nNOS inhibition by both endogenous spermidine and exogenous spermidine is believed to have neuroprotective effects, including anti-depressive effects. Moreover, nNOS inhibition is responsible for a significant decrease in muscle deformities and degeneration of spinal neurons making this function of spermidine a protective function.

Spermidine, along with other polyamines, has been shown to have the same effect on the cell cycle as growth factors which also supports its main function; autophagy and longevity. Moreover, spermidine binds to different compounds to support different functions of the compound.

Uses of Spermidine Powder

Spermidine powder is used as a supplement to prevent different types of cancer, especially hepatocellular carcinoma and liver fibrosis. Most people choose to take spermidine powder as a supplement because of its ability to not only improve longevity but also because of the protective effects of the compound.

Benefits of Spermidine Powder as a Supplement

Spermidine’s use as a supplement was only recently implemented but has been heavily backed by scientific research that has found it to have multiple benefits on the human body. Some of the main benefits of spermidine powder as a supplement are:

· Improved Memory and Enhanced Cognitive FunctionThe use of spermidine powder is associated with neuroprotective properties although that is not the main feature responsible for the rising popularity of the compound. Spermidine’s positive effect on the brain and cognition is a result of its anti-inflammatory properties that inhibit inflammation in the neurons, hence decreasing the incidence of several neurodegenerative disorders like Parkinson’s Disease and Alzheimer’s Disease.

A recent study focused to study the effect of this particular polyamine as polyamines can have both neuroprotective and neurotoxic effects. Spermidine was studied in animal models with neurodegenerative disorders, especially neurodegeneration as a result of hypoxic-ischemic insult. It was found that this insult resulted in inflammation through decreased actions of nitric oxide in the brain. However, the use of spermidine resulted in decreased inflammation as it was found that it increase the enzyme, nitric oxide synthase in the brain which is essential for the synthesis of nitric oxide, and eventually, treatment of inflammation. This study proved the anti-inflammatory effects of spermidine and its successor, spermine in vivo in animal models.

A similar study was performed on animal models with motor impairments and decreased dopamine levels, as a result of exposure to rotenone. Rotenone exposure in these models results in motor deficits similar to the motor deficits seen in people suffering from Parkinson’s disease. Scientists conducting the study found that spermidine has antioxidant properties that help rescue the dopaminergic neurons that were affected by rotenone in the rats while also combating the effects of proinflammatory cytokines and oxidative stress. These stressors result in damage to the neurons and result in a marked decrease of neurotransmitters like serotonin, norepinephrine, and dopamine.

Spermidine use rescued these neurons in the animal models and reversed the motor deficits caused by rotenone exposure, hence, proving the hypothesis that spermidine has neuroprotective properties.

Similarly, a study was performed to analyze the effects of dietary spermidine on cognitive function. It is a well-known fact that aging has a negative effect on cognitive function, however, it is hypothesized that these effects can be counteracted by the use of spermidine powder supplements.

When studying animal models that were given spermidine supplements, it was found that it can cross the blood-brain barrier and increase hippocampal function and mitochondrial function in the brain. This is especially important as the hippocampus is important for memory formation and cognition, and improving its function may be especially beneficial in combating physiological and pathological deterioration of hippocampal function.

Basically, spermidine has anti-inflammatory and antioxidant properties along with the ability to cross the blood-brain barrier which allows it to be a neuroprotective agent in the human body.

· Anti-Aging Properties with Increased AutophagySpermidine is a naturally found compound in the human body that plays an important role in the longevity of the cells. It binds to DNA, RNA, and other positively charged molecules which allows it to take part in multiple metabolic processes. The results of these processes are improved cell growth, cell proliferation, and anti-aging of the body. However, it is unable to combat the effects of aging and cell death as one ages because the levels of spermidine begin to decrease from middle age.

Aging is a complex genetic process that occurs in response to different stressors and stimuli which can cause cell death. Consumption of dietary spermidine powder supplements is believed to have an anti-aging effect on the human body through its ability to induce autophagy. Simply put, autophagy is a cellular process, which when translated means ‘eating one’s self’. This process is responsible for the digestion of non-functional or misfolded organelles and proteins, respectively, leading to the destruction of cells that can no longer perform the necessary functions. Despite its function appears to be a harmful one, autophagy has a protective effect on the cells as it removes the cells that are no longer effective.

The use of spermidine trihydrochloride powder is associated with increased autophagy in the human body which is helpful in anti-aging processes as it removes the nonfunctional cells, promoting the production of newer and functional cells. This cellular rejuvenation is crucial to prevent dysfunctional cells from remaining in the body resulting in exaggerated effects of aging.

The induction of autophagy by spermidine powder also plays a role in the immune system, especially in T cells. A recent study has found that autophagy boosting agents, such as spermidine, may be beneficial in improving elderly patients’ response to vaccines. The researchers aim to pass this information to vaccine centers and hope to make the use of dietary spermidine a general protocol for elderly patients being vaccinated.

Apart from autophagy, spermidine also has anti-aging properties as a result of other processes that help inhibit six out of nine hallmarks of aging in the human body. As one ages, the stem cells lose their ability to differentiate into different cell types that have either died, migrated, or lost their functional abilities. This results in irreversible changes in the human body such as graying of hair and the entire process is referred to as stem cell exhaustion. This hallmark of aging is inhibited or fought by dietary spermidine powder supplements which can increase the longevity of the stem cells.

Epigenetic alteration is another hallmark of aging that refers to changes in the genetic components of the cell along with cell structure and physiology as a result of exposure to different environmental factors. These environmental toxins induce changes in the cells that negatively affect the cell causing early aging of the cells and eventually, cell death. This hallmark is also combated by spermidine use as it is known for promoting cellular rejuvenation.

As cells age, they direct most of their energy to self-preservation which leads to altered negative extracellular communication as the cell will damage other cells trying to preserve its own health and stimulate longevity. However, this, in the long run, can have a deteriorating effect on tissue and organ health, which is a frequent finding in aging individuals. However, the use of spermidine is believed to reduce the alteration of communication between cells to promote longevity of all cells, without harming other cells in the tissue.

Proteins play an important role in the cells and are necessary for all metabolic processes to be performed properly. Proteins need to be constructed properly in the body to ensure the proper functioning of the body along with the maintenance of homeostasis. With age, proteins lose their ability to hold on to their specific structure which allows them to perform specific functions. Environmental stressors affect these proteins and the mechanisms leading to the production and maintenance of these protein structures. This is referred to as loss of proteostasis and is an important hallmark of aging.

The lifespan of the cell ends and the cell enters the senescence period when the telomeres of the cell are too short for the cell to be able to divide anymore. Telomeres keep shortening as the cell divides and eventually it reaches a size too small to allow further cell division, leading to telomere silencing. After this, the cell cannot divide and will eventually die off. Telomere shortening is an important hallmark of aging that has been studied and researched thoroughly for the development of anti-aging compounds. Spermidine is found in the body and is responsible for opposing the effects of telomere silencing, allowing the cells to divide freely for a longer period of time.

Spermidine improves mitochondrial functions and reduces the effect of oxidative stress on the body. This is another hallmark of aging that can be opposed by using dietary spermidine powder supplements.

· Prevents Certain Types of Cancers from DevelopingSpermidine is believed to have anti-neoplastic effects as it has been found that individuals taking spermidine have a decreased risk of developing hepatocellular carcinoma and its preceding condition, liver fibrosis. A recent research found that spermidine is able to stop liver fibrosis from developing even in animal models that were being actively exposed to chemicals with the ability to produce liver fibrosis.

An observational study has found that spermidine use has the potential to prevent colon cancer, although further research needs to be performed before it is added to the treatment and prevention guidelines.

Moreover, it was found that the use of spermidine in chemotherapy patients undergoing treatment for skin cancer and gastric cancer helped improve the outcomes of the treatment and improve prognostic factors of cancer.

· Maintain proper Circadian RhythmSpermidine supplements are often advertised as sleep initiating and maintaining products while also focusing on the improvement of the circadian rhythm. A study performed on animal models found that older mice, with low levels of spermidine in their body, had a slower circadian rhythm which often develops as sleeping disorders. When supplemented with spermidine powder, these older mice were found to have a more active circadian rhythm with a normal circadian cycle.

· Beautification of Hair, Nails, and SkinSpermidine rejuvenates cells and promotes healthy cell growth which reverses the effects of aging on the skin, hair, and nails. Aging takes a toll on the appearance of the texture of the skin, with aging skin appearing wrinkled and saggy with a crepey texture. These effects can be reversed using spermidine supplements that are actively recommended for the beautification of hair, nails, and skin.

Which Foods are Rich in Spermidine Powder?

Spermidine is found naturally in multiple food sources, mostly those belonging to Mediterranean cuisine. The food sources of spermidine are mentioned below:

Durian

Wheat germ

Green Peppers

Broccoli

Mushroom

Cauliflower

Cheeses (different types have different spermidine content)

Natto

Shiitake mushroom

Amaranth grain

The Wheat Germ is an important source of spermidine, which is stored in its endosperm. The importance of this food source of spermidine is that it is often used in the production of the spermidine supplements as a source of the compound.

What is Spermidine Wheat Germ Extract?

Spermidine as a dietary supplement is derived from the wheat germ which is rich in spermidine. To manufacture this supplement from the wheat plant, a wheat kernel is treated to extract its spermidine from the endospore. Fermented wheat gram extract is produced by treating the extract from the wheat kernel with an extract of yeast. Also known as Fermented Extract Of Wheat Germ, FWGE, MSC, Triticum Aestivum Germ Extract, and Triticum Vulgare Germ Extract, this product is what provides spermidine dietary supplements with spermidine.

Uses of Spermidine Wheat Germ Extract

The spermidine wheat germ extract is recommended for people wanting to reverse the effects of aging in their body, such as graying of hair, wrinkling of the skin, and decreased energy production. Some of the other uses of FGWE include:

Sunburns: As spermidine is able to promote cell growth, proliferation, and rejuvenation, it is believed that cells damaged by UV exposure may benefit from the effects of spermidine. These cells are hypothesized to undergo an autophagic process as a result of spermidine consumption, which then will lead to newer cells being generated to treat the sunburn.

Prevention of fever in chemotherapy patients: spermidine plays an important role in the immune system through its autophagic properties, and it is these properties that help spermidine germ wheat extract powder to promote the destruction of chemotherapy damaged cells and induce proliferation of new cells. This helps regenerate healthy and functional T cells in the body which help these patients fight the recurrent infections.

Management of autoimmune disorders: Spermidine has anti-inflammatory properties which help in the management of autoimmune disorders with pro-inflammatory features.

The spermidine wheat germ extract is mostly used by cancer patients as it is hypothesized to stop the progression of cancer and inhibits its growth. Moreover, it is believed that daily use of dietary spermidine supplement is beneficial in preventing the development of cancer in the first place, and can reverse the effects of cancer while also managing the adverse effects of cancer treatment.

Side Effects of Spermidine Powder Use

Spermidine is a polyamine that is found naturally in the body, the excess of which has no side effects in the human body. However, low levels of spermidine in the body are related with early aging, decreased memory and cognitive function, along with decreased structural stability and integrity of the skin. It also results in impaired mitochondrial function which then exaggerates the effects of aging in the body.

Spermidine supplements that are manufactured using high quality wheat germ extract and by following all safety guidelines and protocol and considered safe for human consumption. These supplements have been thoroughly studied and no significant side effects have yet been discovered, hence calling for further research to be formed. It is important to note that no spermidine powder toxicities have yet been reported

Why Choose Our Spermidine Powder Manufacturing Factory?

Spermidine powder is a stable compound that is also found in the body. In our manufacturing factory, spermidine powder is produced in a professional, sterile laboratory to ensure the safety of the product. The product is manufactured following the guidelines and safety protocols to ensure maximal benefits of the spermidine compound while also reducing the possibility of contamination or reaction of the compound with other products. Moreover, the products are lab tested after production to ensure their safety, efficacy and potency. Any spermidine product that does not pass this testing is not packaged and prepared for sale but rather sent back, and the other products in the same batch are subjected to extensive training to ensure there is no problem with quality of the spermidine powder.

Spermidine powder is available wholesale at our factory, although it is only sold for research and development purposes, or for its application in the field of pharmaceuticals. Spermidine is a pharmaceutical intermediate and an important substrate in medicinal and biological chemistry. For these purposes, high quality Spermidine powder is required, which is available at our Spermidine manufacturing factory.

Spermidine powder from our manufacturing facilities is available for purchase in different packages and conditions, depending on the demands of the consumers. Each package has a label with the date of testing and production date, to ensure easier quality control checks and tracking services.

Reference:

Mortimer RK, Johnston JR (1959). “Life Span of Individual Yeast Cells”. Nature. 183 (4677): 1751–1752. Bibcode:1959Natur.183.1751M. doi:10.1038/1831751a0. hdl:2027/mdp.39015078535278. PMID 13666896

Experimental drug targeting Alzheimer’s disease shows anti-aging effects” (Press release). Salk Institute. 12 November 2015. Retrieved November 13, 2015.

Researchers identify the molecular target of J147, which is nearing clinical trials to treat Alzheimer’s disease”. Retrieved 2018-01-30.

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature Peter T. Nelson, Irina Alafuzoff, Eileen H. Bigio, Constantin Bouras, Heiko Braak, Nigel J. Cairns, Rudolph J. Castellani, Barbara J. Crain, Peter Davies, Kelly Del Tredici, Charles Duyckaerts, Matthew P. Frosch, Vahram Haroutunian, Patrick R. Hof, Christine M. Hulette, Bradley T. Hyman, Takeshi Iwatsubo, Kurt A. Jellinger, Gregory A. Jicha, Enikö Kövari, Walter A. Kukull, James B. Leverenz, Seth Love, Ian R. Mackenzie, David M. Mann, Eliezer Masliah, Ann C. McKee, Thomas J. Montine, John C. Morris, Julie A. Schneider, Joshua A. Sonnen, Dietmar R. Thal, John Q. Trojanowski, Juan C. Troncoso, Thomas Wisniewski, Randall L. Woltjer, Thomas G. Beach J Neuropathol Exp Neurol. Author manuscript; available in PMC 2013 Jan 30. Published in final edited form as: J Neuropathol Exp Neurol. 2012 May; 71(5): 362–381. doi: 10.1097/NEN.0b013e31825018f7

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1000KG Urolithin A Urolithin Powder Urolithin B Factory Supply In Stock

Wisepowder have the capability to produce and supply large quantity of Urolithin powder series, include Urolithin A, Urolithin B, Urolithin C...All Urolithin powder production under cGMP condition and strict quality control system, all testing documents and sample available. Full in stock, monthly production capacity more than 800KG-1000KG.Welcome inquiry and discuss cooperation. 

Urolithin A Powder CAS 1143-70-0

Urolithin A, a gut-microbial metabolite of ellagic acid, exerts anti-inflammatory, antiproliferative, and antioxidant properties. Urolithin A induces autophagy and apoptosis, suppresses cell cycle progression, and inhibits DNA synthesis. Urolithin A is not known to be found in any food source. Its bioavailability mostly depends on individual microbiota composition, as only some bacteria are able to convert ellagitannins into urolithins.

Manufacture:  Batch Production

Package:  1KG/bag, 25KG/drum

Urolithin A powder Base Information

Name Urolithin A Powder

CAS 1143-70-0

Purity 98%

Chemical name 3,8-Dihydroxybenzo[c]chromen-6-one

Synonyms 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one; 3,8-DIHYDROXYDIBENZO-(B,D)PYRAN-6-ONE; 3, 8-Dihydroxy-6H-benzo[c]chromen-6-one; Castoreum pigment I; Urolithin A; 6H-Dibenzo(B,D)pyran-6-one, 3,8-dihydroxy-; 3,8-dihydroxy-6H-dibenzopyran-6-one); urolithin-A(UA;3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one

Molecular Formula C13H8O4

Molecular Weight 228.2

Melting Point >300 °C

InChI Key RIUPLDUFZCXCHM-UHFFFAOYSA-N

Form solid

Appearance Light Yellow powder

Half Life /

Solubility Soluble in DMSO (3 mg/mL).

Storage Condition Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).

Application Urolithin A is a metabolite of ellagitannin; Pharmaceutical Intermediates

Testing Document Coa, MSDS, HPLC..

Testing Sammple   available

Urolithin A Sample 

Urolithin A Powder General Description

Urolithin A powder is a metabolite compound resulting from the transformation of ellagitannins by the gut bacteria and is an inducer of mitophagy. Urolithin A shifts mitochondria from CI- to CII-driven respiration, extends lifespan and improves muscle function. It belongs to the class of organic compounds known as benzo-coumarins or dibenzo-α-pyrones. Its precursors – ellagic acids and ellagitannins – are ubiquitous in nature, including edible plants, such as pomegranates, strawberries, raspberries, and walnuts. Since the 2000s, urolithin A has been subject of preliminary studies regarding its possible biological effects.

Urolithin A powder can improve the quality and function of mitochondria, and increase the strength and endurance of aging muscles. It is the only natural product that has been proven to restart mitochondrial autophagy and reverse muscle aging.

Urolithins are microflora human metabolites of dietary ellagic acid derivatives，such as ellagitannins. They are produced in the human gut, and found in the urine in the form of urolithin B glucuronide after absorption of ellagitannins-containing food such as pomegranate, strawberries, red raspberries, walnuts or oak-aged red wine.

During intestinal metabolism by bacteria, ellagitannins and punicalagins are converted to urolithins, which have unknown biological activity in vivo in humans. Urolithins metabolites of pomegranate juice ellagitannins localize specifically in the prostate gland, colon, and intestinal tissues of mice.

Ellagitannins exhibit low bioavailability and are transformed in the gut to ellagic acid and its microbiota metabolites.

Urolithins are found in plasma mostly as glucuronides at low concentrations.

Urolithins production is dependent on the gut microbiome enterotype. Individuals producing urolithins show a much higher abundance of the Clostridium leptum group of Firmicutes phylum than Bacteroides or Prevotella

Urolithin A powder History

In laboratory studies, urolithin A powder was shown to induce mitophagy, which is a selective recycling of mitochondria by autophagy, a process that cleans defective mitochondria following damage or stress, and tends to become less efficient during aging.[14] This effect has been observed in different animal species (mammalian cells, rodents and C. elegans).

Urolithin A powder Application

Urolithin A powder is intended for use as an ingredient in select foods or for special dietary uses in meal replacement products based on its nutritive activity in supporting general mitochondrial health.

Urolithin A powder More research

Urolithin A is not known to be found in any food. It forms as the result of transformation of ellagic acids and ellagitannins by the gut microflora in humans. Ellagic acid itself results from the hydrolysis of ellagitannins in the gut in the presence of water.[citation needed]

Sources of ellagitannins are: pomegranates, nuts, some berries (raspberries, strawberries, blackberries, cloudberries), tea, muscadine grapes, many tropical fruits, and oak-aged wines (table below).

The conversion of the ellagic acids into urolithin A depends on individual microflora composition and can vary significantly.

Urolithin B powder CAS 1139-83-9

Urolithin B is a natural metabolite of ellagitannin present in pomegranates and other fruits and nuts. Recognized by scientists as an anti-aging drug, oral administration can restore mitochondria and reverse muscle aging, and is a potent intestinal metabolite.

Manufacture:  Batch Production

Package:  1KG/bag, 25KG/drum

Urolithin B powder base information

Name Urolithin B Powder

CAS 1139-83-9

Purity 98%

Chemical name 3-Hydroxy-6H-dibenzo[b,d]pyran-6-one

Synonyms AURORA 226; Urolithin B; AKOS BBS-00008028; 3-hydroxy urolithin; 3-hydroxy-6-benzo[c]chromenone;3-hydroxybenzo[c]chromen-6-one; 3-Hydroxy-benzo[c]chromen-6-one; 3-HYDROXY-6H-DIBENZO[B,D]PYRAN-6-ONE; 6H-Dibenzo(b,d)pyran-6-one, 3-hydroxy-;3-Hydroxy-6H-benzo[c]chromen-6-one AldrichCPR

Molecular Formula C13H8O3

Molecular Weight 212.2 g/mol

Melting Point 247 °C

InChI Key WXUQMTRHPNOXBV-UHFFFAOYSA-N

Form Solid

Appearance Light brown powder

Half Life /

Solubility soluble5mg/mL, clear (warmed)

Storage Condition 2-8°C

Application Urolithin B is an intestinal microbial metabolite of ellagitannis and exhibits potent anti-oxidant and pro-oxidant activies depending on the assay system and conditions. Urolithin B can also display estrogenic and/or anti-estrogenic activity.

Testing Document Coa,MSDS,HPLC…etc

Urolithin B sample: available

Urolithin B powder General Description

Urolithin B is an urolithin, a type of phenolic compounds produced in the human gut after absorption of ellagitannins-containing food such as pomegranate, strawberries, red raspberries, walnuts or oak-aged red wine. Urolithin B is found in the urine in the form of urolithin B glucuronide.

Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects. Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhances the phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass. Urolithin B can also display estrogenic and/or anti-estrogenic activity.

Urolithin B powder History

Urolithin B can be used as an drug for antitumor and anticancer. Urolithin B( CAS NO :1139-83-9) is an urolithin ,it is also produced in the human gut after absorption of ellagitannins from pomegranate. Urolithin B can mitigate muscle damage experienced during intense exercise and protect muscle against stresses induced by a high-fat diet.

Urolithin B powder is  also an intestinal microbial metabolite of ellagitannis and exhibits potent anti-oxidant and pro-oxidant activies depending on the assay system and conditions. Urolithin B can also display estrogenic and/or anti-estrogenic activity. It has anti-inflammatory and antioxidant effects. Urolithin B is also used be a regulator of skeletal muscle mass.

And Urolithin B has been shown to cross the blood brain barrier, and may have neuroprotective effects against Alzheimer’s Disease.

Urolithin B powder More research

Urolithin B can mitigate muscle damage experienced during intense exercise and protect muscle against stresses induced by a high-fat diet. Clinical research on Urolithin B in mice found that it enhanced myotubes growth and differentiation by increasing protein synthesis. It demonstrated an ability to inhibit the ubiquitin–proteasome pathway (UPP), the principal mechanism for protein catabolism. It also induced muscle hypertrophy and reduced muscle atrophy.

When compared to testosterone, Urolithin B when taken at 15 uM increased androgen receptor activity by 90% while testosterone was only able to accomplish increased receptor activity of 50% at 100uM. This means that it takes a lot less Urolithin B to increase androgen activity more effectively then the higher amount of testosteronewhich increases androgen activity less effectively.

Moreover, most effective 15uM of Urolithin B larger muscle protein synthesis via 96% when in comparison to 100uM of insulin, which larger muscle protein synthesis via most effective 61%. The belief is that it takes a long way much less Urolithin B to extend muscle protein synthesis with a lot upper degree of effectiveness.

This studies show that Urolithin B can inhibit protein catabolism while simultaneously increase protein synthesis, it is a natural ingredient that helps to build lean muscle while preventing muscle breakdown.

Buy Urolithin A Urolithin B powder In Stock From Wisepowder

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This Is What CBD Isolate Is and How to Use It

CBD isolate, which doesn't contain THC, is a more pure form of CBD, but it may not offer the same benefits as full- or broad-spectrum CBD products.

Understanding CBD

Curious about cannabidiol (CBD)? Maybe you’re thinking about giving it a try, like using CBD for anxiety and sleep. Or maybe you’re interested in using a topical CBD cream for pain or arthritis relief.

“There is in fact a reason to believe CBD could be helpful,” says Roger S. McIntyre, MD, a professor of psychiatry and pharmacology at the University of Toronto. “This is not some type of quackery or nonsense.” Nevertheless, he says, there isn’t enough data on safety and effectiveness in humans to recommend CBD for patients with serious mental illness or for “wellness” in healthy people.

While Dr. McIntyre does not recommend CBD to his patients, he acknowledges that many of them use it anyhow. (Here’s how one woman used CBD oil for insomnia.) He asks those who do use cannabis-based medicines to let him know, so he can look out for potential interactions with other medications.

For those who want to try CBD but don’t want to risk ingesting trace amounts of delta-9-tetrahydrocannabinol (THC)—the main mind-altering chemical found in marijuana—CBD isolate may be the best option.

Here’s what you need to know about CBD isolate, including benefits, risks, how to make it, use it, and where to buy it.

What is CBD isolate?

CBD isolate is a compound that comes from the plant Cannabis sativa. Because of the way manufacturers extract (or isolate) the CBD from all of the other components of the plant, it’s the purest form of CBD.

It does not have a particular smell or taste and can come in different forms, including CBD isolate crystal, CBD isolate powder, and CBD isolate oil.

As the name suggests, CBD isolate crystal is CBD in pure, crystalline form. It can be mixed into liquids and even vaping pipes. With CBD isolate powder, the crystal is ground into a powder, making it easier to ingest.

Indeed, the powder form is the easiest to ingest. It can be mixed into edibles like gummies or liquids like tea and juice. CBD isolate can also be mixed with carrier oils to make CBD oil. (More on how to create your own CBD isolate oils and products later.)

Benefits of CBD isolate

CBD has been used to alleviate health ailments like anxiety, pain, inflammatory conditions, epilepsy, and cancer symptoms. But how well or if it actually works for all of these indications has yet to be determined. (A CBD oil-based drug, Epidiolex, was approved by the Food and Drug Administration in 2018 for the treatment of seizures in a handful of rare types of epilepsy.)

Evidence of CBD’s benefits in humans still lags behind promising findings from lab and animal studies, experts agree.

“The scientific evidence doesn’t seem to be as robust and as compelling at this stage as the enthusiasm for it in the population seems to be,” Dr. McIntyre says.

The entourage effect

Products made with CBD isolate are the purest CBD products available. That’s because they don’t contain additional cannabinoids or any of the other compounds, like terpenes and flavonoids, found in the cannabis plant.

Some experts argue that products that do include other cannabis components—known as full- or broad-spectrum CBD—are more effective than those with CBD only, thanks to what’s called the “entourage effect.” This theory holds that some substances found in cannabis—including CBD and THC—have synergistic effects.

However, a study published in 2019 in Cannabis and Cannabinoid Research finds an “absence of entourage.”

Researchers note that when terpenes were added to THC, there were no changes in CB1 and CB2 cannabinoid receptors—a part of the naturally occurring human endocannabinoid system which is responsible for regulating and balancing body function like immune response and appetite and metabolism. More research is needed to determine how exactly the entourage effect works.

Side effects of CBD isolate

CBD isolate is relatively low risk compared to cannabis products that contain THC. There are, however, side effects of CBD isolate. Those include appetite and weight fluctuations, diarrhea, fatigue, insomnia, and  irritability, according to the U.S. Food and Drug Administration (FDA).

When it comes to dosing, there’s little information on how much people should take since the FDA has approved only the one CBD product for epilepsy. As always, consult a doctor to determine the safety of any CBD product and an effective dosage—especially if you’re taking other over-the-counter or prescription meds.

Differences between CBD oil and isolate

CBD oil is made by extracting cannabinoids, terpenes, and other components from cannabis plants. CBD oil and other products that contain all of these components in addition to CBD (including THC), are called full-spectrum products.

Whole-spectrum products have been processed to remove THC, but leave other cannabinoids and terpenes behind. Further processing to remove everything but the CBD produces CBD isolate, which can be suspended in an oil as well. (Find out if CBD gets you high or will make you fail a drug test.)

CBD isolate vs. full-spectrum

CBD products can be full-spectrum, meaning they contain other cannabinoids and terpenes found in cannabis plants. If full-spectrum products are made from hemp—strains of cannabis that contain no more than 0.3 percent THC—their THC content is likely minimal. Full-spectrum CBD products derived from marijuana with a higher THC content may have higher amounts. (Don’t miss the key differences of CBD oil vs. hemp oil.)

Growing higher-THC cannabis plants—aka marijuana—remains illegal at the federal level. But more and more states are permitting the cultivation and production of higher-THC cannabis for medicinal and recreational use.

Broad-spectrum CBD products are full-spectrum products with the THC removed. But similar caveats apply, because you still might be exposed to trace amounts of THC.

How to make CBD isolate

The first step is to extract CBD from a cannabis plant, which could be either marijuana or hemp (but usually hemp, due to its lower THC level). Tiny hair-like projections on the leaves, flowers, and stems of the plant, known as trichomes, are the richest source of CBD.

Cannabis plants grow several types of trichomes, tiny factories that produce cannabinoids, terpenes, and more to shield the plant from attack by insects, animals, and even damage from ultraviolet rays.

Supercritical carbon dioxide extraction is the safest—and most expensive—way to extract CBD and other substances from plant material. This method doesn’t leave toxic residues behind. But it’s not something most people should try at home. This is a high-tech method requiring expensive equipment and considerable scientific expertise.

The waxy gold oil harvested by this method—or any other extraction approach—must undergo additional refinement in order to produce CBD isolate. The extract may be filtered and then “winterized”—soaked in alcohol and frozen—to remove remaining unwanted material.

How to use CBD isolate

As previously mentioned, CBD crystal isolates can also be smoked or vaped. CBD isolate powder can be added to food and drinks. And CBD isolate oils are also available.

You can also make your own by adding CBD isolate to what’s known as a “carrier oil.” Many different types of oils make good carriers for CBD, including olive oil and hemp seed oil.

Oils made from medium-chain triglycerides—known as MCT oil, and often made using coconut oil—are a popular choice. You can even get CBD isolate with terpenes added back in.

Where to buy CBD isolate

Brick-and-mortar specialty CBD stores in states where CBD is legal sell CBD isolate. There are also online retailers that sell CBD isolate, and offer it in bulk.

“The CBD industry is largely unregulated, so using reputable brands is critical,” says Melinda Ring, MD, the executive director of Osher Center for Integrative Medicine at Northwestern University in Chicago. “Sites like Wisepowder pharma do independent quality tests and are a good starting point if considering buying CBD products online or in stores.”

Also, when buying CBD products, check to make sure it’s undergone third-party inspection, and has a Certificate of Analysis (COA) available to prove it.

If you’re in a state where recreational marijuana is legal, you may be able to buy vetted CBD-rich products from a dispensary. Medical marijuana dispensaries often stock high-CBD, low-THC products, tested for purity and potency as required by state regulations. They may also offer CBD isolates.

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What to know about CBD isolate

CBD isolate is a form of CBD, or cannabidiol, which is a chemical compound present in the cannabis plant. Unlike full-spectrum CBD products, CBD isolate does not contain any THC — the psychoactive component of cannabis.

CBD isolate is a good option for those who would like to try CBD, but who cannot or do not want to ingest any tetrahydrocannabinol (THC), which is the active ingredient in cannabis. Most other CBD products contain at least a small percentage of THC.

Keep reading to learn more about CBD isolate, including its potential health benefits and possible side effects.

What is it?

CBD isolate is a crystalline solid or powder comprising pure CBD. It is different from full-spectrum CBD products, which can legally contain up to 0.3% THC. This amount may show up on a drug test, but it will not cause a high.

To produce CBD isolate, manufacturers use various processes to extract all the compounds and other substances from the cannabis plant, including THC. The process leaves behind pure CBD in crystal form.

Manufacturers may then grind the crystals into a powder to make the product easier to consume. CBD isolate does not have a distinctive smell or taste.

Effects

CBD works by acting on the cannabinoid receptors in the human body. These receptors exist because the human body produces its own cannabinoids, which may influence several bodily functions, including:

appetite

memory

mood

pain perception

inflammation levels

Researchers believe that CBD does not attach directly to these receptors, but that it influences them in some way. As a result of this receptor activation, CBD exerts its effects on the human body.

Potential effects of CBD include:

boosting the immune system (immune-modulating)

counteracting the formation of tumors (anti-tumorigenic)

fighting inflammation (anti-inflammatory)

preventing vomiting (antiemetic)

recovery or regeneration of the nervous system (neuroprotective)

reducing or preventing anxiety (anti-anxiety)

reducing or preventing seizures (anticonvulsant)

relieving pain (analgesic)

Studies indicate that CBD can also influence non-cannabinoid receptors, such as the 5-Hydroxytryptophan (5-HTP) serotonin receptor. Serotonin is a chemical that affects levels of depression, anxiety, and sleeplessness, among others. This may help explain why CBD eases anxiety and pain in some people.

One study in mice suggests that while CBD isolate does offer certain health benefits. However, some of these may have less effect than those gained from using a full-spectrum CBD product.

Results from the study indicate that CBD isolate is only effective against pain and swelling at a specific dose. Meanwhile, full-spectrum CBD products will continue to provide increasing effects as the dosage increases.

That said, CBD isolate is still a useful option for people who must refrain from having any THC in their system, or for those who do not need a full-spectrum CBD product.

It is important to note that products labeled THC-free may still contain enough THC that a person could fail a urine toxicity test. Always check the labels and packaging carefully.

Uses and benefits

CBD isolate may help treat the following conditions:

Anxiety

Several studies indicate that CBD has anti-anxiety effects. It likely works by changing the way the brain responds to the chemical serotonin.

A 2019 study, for example, explored whether CBD improves sleep or anxiety, or both. The researchers reviewed the charts of 72 adults who had anxiety or sleeping problems at a psychiatric clinic.

The researchers found that after CBD treatment, 79% of the participants reported decreased anxiety. Almost 67% of people saw improved sleep scores within the first month, but these fluctuated over time.

The researchers conclude that CBD may benefit those with anxiety disorders and that most people tolerate it well.

Another 2019 study suggests that CBD significantly decreased anxiety in teenagers with social anxiety.

Pain and inflammation relief

People often use CBD to treat a variety of inflammatory conditions and types of pain, including:

arthritis pain

cancer pain

chronic back pain

fibromyalgia

neuropathic pain

While CBD isolate may provide pain relief, research indicates that a full-spectrum CBD product may be even more effective because cannabidiol acts synergistically with THC to boost its analgesic effects.

Epilepsy

CBD demonstrates antiseizure effects, which means it has the potential to treat epilepsy. According to the American Epilepsy Society, CBD research offers hope for those with the condition.

A 2017 study cites strong evidence to indicate that CBD improves seizure control in those with specific epilepsy syndromes.

However, research is still in its early stages, and much more exploration is necessary before people with epilepsy can take CBD as a reliable source of symptom management.

Those who have epilepsy should discuss their treatment options with a doctor or healthcare provider.

Cancer and the effects of cancer treatment

Research into the effects of CBD on cancer growth is also in the early stages. However, some animal studies do indicate that it might prevent the growth of cancer cells.

The National Cancer Institute indicates that CBD may alleviate some cancer symptoms and side effects of cancer treatment (including nausea and vomiting).

However, the Institute does not endorse any form of cannabis as a treatment due to insufficient research.

Side effects

CBD isolate is generally a low-risk substance, especially as it does not contain THC. However, in some people, it may cause adverse reactions that include:

an increase or decrease in appetite

diarrhea

fatigue

weight loss or weight gain

insomnia

Irritability

CBD can also interact with some prescription or over-the-counter medications, so always talk to a doctor before using CBD or other cannabis products.

It can also interact with some dietary supplements. Individuals should take care if their medications or supplements carry a warning about grapefruit. Common examples include cholesterol drugs, such as atorvastatin (Lipitor) and others.

Both grapefruit and CBD can interfere with the metabolism of these medications. Anyone taking medication or supplements that carry a grapefruit warning should avoid CBD as well.

One study in mice indicated that CBD might also increase the risk of liver toxicity if taken in significant quantities. Anyone considering using CBD should talk to their doctor or one who specializes in CBD to evaluate their risk.

Find out more about doses of CBD here.

Summary

CBD isolate offers an alternative to full-spectrum CBD products. It may be especially useful for those who would like to try CBD without ingesting any of the psychoactive compound THC.

CBD isolate demonstrates several benefits, including relief from pain, inflammation, and anxiety.

Research indicates that some of these benefits may be more pronounced when taking a full-spectrum CBD product, however.

When choosing a CBD isolate, always buy from a reputable company and read the label carefully to ensure it is free from THC, other chemicals, and impurities.

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CBD Isolate Powder 13956-29-1

CBD isolate is a crystalline solid or powder that contains 99% pure CBD. CBD Isolate unlike full-spectrum CBD products, CBD Isolate dose not contact any THC-the psychoactive component of cannabis(THC free). So CBD isolate pure powder is a good option for those who would like to try CBD, but who cannot or do not want to ingest any tetrahydrocannabinol (THC), which is the active ingredient in cannabis. Most other CBD products contain at least a small percentage of THC.

CBD isolate powder is used in edibles, pain relief ointments and is the preferred form of CBD for dabbing.

Chemical Base Information：

Name

CBD Isolate

CAS

13956-29-1

Purity

99% Isolate / Extrapure Isolate (CBD≥99.5%）

Chemical name

CANNABIDIOL

Synonyms

CBD; C07578; CBD oil; CBD crystal; CANNABIDIOL;CBD Isolate; (1r-trans)-;CBD powder 99%; CBD,CANNABIDIOL; (-)-CANNABIDIOL

Molecular Formula

C21H30O2

Molecular Weight

314.46

Melting Point

62-63°C

InChI Key

QHMBSVQNZZTUGM-ZWKOTPCHSA-N

Form

Solid

Appearance

White to light yellow crystalline powder

Half Life

18–32 hours

Solubility

Soluble in oil, extremely soluble in ethanol and methanol, insoluble in water

Storage Condition

Room temperature, keep dry and away from light

Application

For scientific research purposes only, or as raw materials for downstream product development, or for sale in legitimate countries and regions abroad. Please note these products should not be directly consumed or used for clinical treatment in China mainland

Testing Document

Available

What Is CBD Isolate Powder 13956-29-1?

CBD isolate is a crystalline solid or powder that contains 99% pure CBD. It is Cannabidiol in its purest state currently available on the market today. CBD Isolate is 99% pure, white crystalline that is ground up into powdered form. Therefore, it is 100% THC free and free of other plant compounds including terpenes and other cannabinoids. It contains no psychoactive components.CBD Isolate powder may influence several bodily functions, including:

appetite

memory

mood

pain perception

inflammation levels

How Does CBD Isolate Powder Work/The Mechanism Of CBD Isolate Powder?

CBD Isolate have good effects on body is because CBD works by acting on the cannabinoid receptors in the human body. These receptors exist because the human body produces its own cannabinoids.

Researchers believe that CBD does not attach directly to these receptors, but that it influences them in some way. As a result of this receptor activation, CBD exerts its effects on the human body.

CBD Isolate Powder History

Efforts to isolate the active ingredients in cannabis were made in the 19th century. Cannabidiol was studied in 1940 from Minnesota wild hemp and Egyptian Cannabis indica resin. The chemical formula of CBD was proposed from a method for isolating it from wild hemp. Its structure and stereochemistry were determined in 1963.

Why Buy CBD Isolate Powder/What Are The Benefits Of CBD Isolate Powder?

1. Anxiety, Depression, and Stress

Several studies indicate that CBD Isolate powder has anti-anxiety effects. It likely works by changing the way the brain responds to the chemical serotonin.One 2011 study looked into CBD’s effects on people with SAD (seasonal affective disorder) . SAD is a type of depression that sufferers experience through the winter months when it’s cold, wet, and dark.Another 2019 study suggests that CBD significantly decreased anxiety in teenagers with social anxiety.

2. Pain Relief

People often use CBD Isolate powder to treat a variety of inflammatory conditions and types of pain, including:

arthritis pain

cancer pain

chronic back pain

fibromyalgia

neuropathic pain

While CBD isolate may provide pain relief, research indicates that a full-spectrum CBD product may be even more effective because cannabidiol acts synergistically with THC to boost its analgesic effects.

3. Inflammation Relief

Studies show that CBD Isolate powder has anti-inflammatory properties.

Research has discovered that CBD can relieve inflammation and pain in people with inflammatory conditions when used in topical and ingested forms.

With the potential to relieve arthritis, psoriasis, dermatitis, acne, and much more, the anti-inflammatory benefits of CBD are valuable to a wide group of people.

4. Alleviate Nausea

There’s limited scientific evidence that proves CBD Isolate powder is an effective anti-nausea drug. However, there is a lot of anecdotal evidence to suggest it’s effective.

Some cancer patients use CBD to reduce nausea and other side effects of cancer treatments and therapies with excellent results.

One study from 2011 suggests CBD can help with nausea due to its interaction with serotonin receptors . The study involved animal testing and found that their nausea response was greatly reduced when CBD was administered to rats.

5. Cancer Treatment

Research into the effects of CBD on cancer growth is also in the early stages. However, some animal studies do indicate that it might prevent the growth of cancer cells.

The National Cancer InstituteTrusted Source indicates that CBD may alleviate some cancer symptoms and side effects of cancer treatment (including nausea and vomiting).

However, the Institute does not endorse any form of cannabis as a treatment due to insufficient research.

The benefits of CBD Isolate powder goes on….

6. THC Free

Pure CBD is 100 percent THC-free for those who must or prefer to not have any trace amounts of THC in their system. so there’s no need to worry about THC possibly entering your system and showing up on a potential drug test. Although it’s highly unlikely, trace amounts of THC found in hemp-derived CBD oil can theoretically cause a positive drug screening result.

7. Easy Usage

Isolate is relatively taste-free, so it’s a great way to add CBD to your own custom formulation. How to use CBD Powder? CBD Powder can be consumed in a variety of ways: CBD powder is most popularly used by mixing it into edibles and CBD oils or CBD capsules. CBD can be smoked or vaporized. CBD powder is often used as a substitute to CBD oils, giving the user the ability to control their dosage.

8. Easy Dosage

CBD powder is easily measurable as there’s nothing else to account for aside from the pure CBD. With other CBD-based products, such as broad-spectrum and full-spectrum CBD oil, the cannabinoid is mixed with other cannabinoids, making it more difficult at times to quantify the exact amount of CBD that is being consumed.

9. Other Benefits Of CBD Isolate Powder

-boosting the immune system (immune-modulating)

-counteracting the formation of tumors (anti-tumorigenic)

-fighting inflammation (anti-inflammatory)

-preventing vomiting (antiemetic)

-recovery or regeneration of the nervous system (neuroprotective)

-reducing or preventing anxiety (anti-anxiety)

-reducing or preventing seizures (anticonvulsant)

-relieving pain (analgesic)

10. Effects on THC

CBD is thought to have an attenuating effect on THC, so it can also be used to decrease or balance out THC effects.

How To Make CBD Isolate Powder?

CBD works by binding with the endocannabinoid receptors in the body’s nervous system optimizes functions regulated by the endocannabinoid system. For this reason, CBD possesses multiple uses for overall wellness. The exact reason why CBD isolates and other CBD products are so helpful is still being studied by researchers and scientists.

Those that need to refrain from consuming THC because of their age, the legality in their state, or because of employer drug testing, CBD isolate is a practical alternative to full spectrum oils, which contain trace amounts of THC.

CBD powder has so many good benefits, how to make CBD Isolate powder?

There are various processes used to produce CBD isolate from industrial hemp extracts, such as supercritical carbon dioxide (CO2) or ethanol-based extractions. The same extraction methods can also be used as a starting point for the production of THC isolate as well, but typically with marijuana plants instead of industrial hemp. To create an isolate, a number of components are removed from the plant, including other cannabinoids, terpenes, and flavonoids, as well as fats, lipids, and other compounds. After that, the CBD compound is separated from the rest of the extraction through a series of chemical washing and separation processes.

Once all of the impurities and solvents are stripped away, you’re left with 99% pure CBD crystalline.

How To Use CBD Isolate Powder?

1. Sublingual

To take CBD isolate powder sublingually is one of the most effective ways to consume CBD.

By this method, CBD is absorbed by the mucous membranes and delivered directly to the bloodstream, bypassing the digestive system and liver to provide more immediate and effective relief. The powder is odorless and has a mild, cannabis flavor.

2. Apply to skin

Mix the CBD isolate with moisturizing oils or lotions and apply it to the area of your skin you’d like to treat.

Applying CBD isolate to your skin allows you to use your preferred topical product while enjoying an extra kick of the isolate and maintaining full control over the CBD dosage. It’s also fun to experiment and make your own DIY topical, whether lotion, salve, or cream.

3. Oral-put into capsule or your foods

Measure out the CBD isolate powder at the dosage you prefer and put into capsules. You can also mix CBD isolate with a variety of ingredients to create CBD-infused food and drinks.What’s more, buying CBD isolate powder in bulk can make this method one of the most economical. However, because CBD is not absorbed very well by the gastrointestinal tract, it has a low oral bioavailability. In order to increase bioavailability, CBD isolate can be added to carrier oils, such as MCT oil, to increase its chances of permeating the gastrointestinal system and reaching the bloodstream

4. Vape or dab it.

Vaping CBD isolate won’t get you high, but it will enable you to enjoy the effects of CBD quickly. CBD isolate can be mixed with terpenes to create homemade CBD concentrates, or it can be dabbed using a concentrate vaporizer or dry herb vaporizer.

What Are The Side Effects Of CBD Isolate Powder?

CBD isolate is generally a low-risk substance, especially as it does not contain THC. However, in some people, it may cause adverse reactions that include:

an increase or decrease in appetite

diarrhea

fatigue

weight loss or weight gain

insomnia

irritability

CBD can also interact with some prescription or over-the-counter medications, so always talk to a doctor before using CBD or other cannabis products.

One study in mice indicated that CBD might also increase the risk of liver toxicity if taken in significant quantities. Anyone considering using CBD should talk to their doctor or one who specializes in CBD to evaluate their risk.

CBD Isolate Vs Full and Broad Spectrum CBD, Which One Is Beeter?

Research suggests that full- and broad spectrum CBD is a more valuable treatment for a wider range of health conditions.

It’s believed that CBD is more effective when consumed alongside other cannabinoids. A full cannabinoid profile is more efficient than singular cannabinoid extractions. This phenomenon is known as the entourage effect.

That being said, CBD isolates still have excellent potential in the health space.

Many studies have been done on pure CBD isolates, and although the conclusion that full-spectrum oils are better, isolates are still effective in treating some conditions.

You may prefer to use a CBD isolate because you want to avoid THC and other cannabinoids entirely. Perhaps you react badly to some other cannabinoids or would prefer to steer clear of full-spectrum products for other reasons.

There are pros and cons to using CBD isolates, just as there are for full- and broad spectrum products.

CBD Isolate: Pros & Cons

Pros:

Contains only CBD

Plenty of product variety

No risk of showing up on a drug test

Suitable for people with adverse reactions to other cannabinoids

Raw oil tastes less than full & broad spectrum CBD oil

Cons:

No entourage effect

May not be a suitable treatment for some condition

Full-Spectrum CBD: Pros & Cons

Pros:

Full entourage effect

Wide product variety

Can treat a range of health conditions

Cons:

May show up on drug tests as it contains trace amounts of THC

Not suitable for people that react to certain cannabinoids or terpenes

Raw oil has a taste that’s unappealing to some

Broad Spectrum CBD: Pros & Cons

Pros:

Has the entourage effect to some extent (minus the THC)

Wide product variety

Effective for multiple health issues

Doesn’t show up on drug tests

Cons:

Doesn’t have the full entourage effect

Raw oil has an unappealing taste to some

How Much CBD Isolate Dosage Should I Take?

How much CBD isolate dosage you should take is depends, it is different for everybody. The dose of CBD isolate can change depends on many factors include:

– individual metabolism,

-the strength of the CBD products you are using

-your body size and weight

-your sensitivity and tolerance to CBD

-the severity of the condition you are treating

Start low and increase the dose until you find what works best for you. The common dosage of CBD is 20-40mg. Even with same dose of CBD, it is common for different people respond very differently to it.

Frequently Ask Questions About CBD Isolate Powder

How Do You Use CBD Isolate Powder?

CBD Isolate Powder is CBD in an extremely fine powder form. CBD Powder is CBD Crystals in their purest form. CBD Powder has many uses, including mixing with e-liquids in order to vape CBD. CBD Powder can also be used to make CBD edibles, CBD topicals and CBD tinctures by simply mixing CBD powder with a carrier oil, like coconut or hemp seed oil.

What Does CBD Make You Fee?

Instead of getting you stoned, CBD makes you feel relaxed and calm without producing any mind-altering effects. You may be surprised to learn that your body produces substances very similar to cannabinoids, known as endocannabinoids, on its own.

Is CBD Isolate Powder Legal?

If your purified CBD comes from hemp plants, it is federally legal, but if it comes from a marijuana plant, it is illegal.

What Is The Best Effective Method To Use CBD Isoate powder?

Most Efficient Method of Consumption – Sublingually-administered CBD is the most direct and efficient form of CBD consumption, having the highest and fastest absorption rate of cannabidiol.

How To Make CBD Isolate Powder Into Oil?

CBD oil can be made from CBD isolate by combining it with a carrier oil like MCT oil, grapeseed oil or olive oil. MCT oil is the most popular carrier oil used for formulating CBD oil from isolate.

How Can You Tell High Quality CBD Isolate Powder?

A reputable CBD product will come with a COA. That means it’s been tested by laboratory prove it’s purity. For powerful CBD isolate powder manufacturers, they can provide other offical professional testing result to prove the quality, such as HPLC,NMR, not all factory can provide such kinds of testing documents, as they need professional technology team and equipments.

Is CBD Same As CBD Isolate?

CBD is cannabidiol, a phytocannabinoid found in cannabis plants. CBD isolate is CBD that has been isolated from all other plant material through a process of extraction and refining. CBD isolate is available in crystal or powder form.

Is CBD isolate Better Than full-spectrum CBD?

It depends on who you ask and why they are using CBD. Isolate is best for avoiding any possible trace of THC while full-spectrum may confer the additional benefits of other cannabinoids and terpenes via the entourage effect.

How To Buy CBD Isolate Powder Online?

CBD isolate, which doesn’t contain THC, is a more pure form of CBD. Wisepowder is wholesale the 99% pure CBD Isolate powder, our Wholesale CBD Isolate is the best  powder in the industry.  When buy CBD isolate powder in bulk online, check to make sure it is undergone lab inspection and has a Certificate of Analysis(COA) available to prove it. There are too many CBD isolate powder suppliers in the market, the powerful CBD isolate powder manufacturer will have the professional technology and equipments, strict quality system to ensure the products quality.

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99% Pure CBD Isolate Powder CAS 13956-29-1

99% Pure CBD Isolate Powder CAS 13956-29-1

CBD isolate is a crystalline solid or powder that contains 99% pure CBD. CBD Isolate unlike full-spectrum CBD products, CBD Isolate dose not contact any THC-the psychoactive component of cannabis(THC free). So CBD isolate pure powder is a good option for those who would like to try CBD, but who cannot or do not want to ingest any tetrahydrocannabinol (THC), which is the active ingredient in…

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Fisetin and Longevity

Summary:

Fisetin is a natural substance found in strawberries and apples.

Fisetin extends lifespan in various organisms.

Fisetin reduces the amount of senescent cells, which are cells that increase during aging and damage healthy surrounding cells, accelerating the aging process.

Fisetin seems to be better than quercetin in killing senescent cells.

Fisetin can improve cognition and memory.

Fisetin inhibits the mTOR pathway. mTOR accelerates aging.

Fisetin improves skin health, for example by reducing the production of metalloproteinases which are enzymes that break down collagen and elastin.

Fisetin Impacts Aging Via

Cellular senescence

Altered intercellular communication

Loss of proteostasis

The role of fisetin in aging and longevity

Fisetin is a naturally occurring substance found in fruits and vegetables, such as strawberries, apples, grapes, onions, and cucumbers.

Fisetin is a flavonoid. Flavonoids are substances that give fruits and vegetables their bright colors (like yellow, orange and blue) and play a major role in conferring the health benefits that we get from eating more vegetables and fruits.

Fisetin eliminates senescent cells

Fisetin is probably most known for its impact on senescent cells: studies showed that this substance can reduce the accumulation of senescent cells (R). Fisetin is a senolytic, a compound that can clear away senescent cells.

Senescent cells accumulate everywhere in the body during aging.

Senescent cells were previously normal cells that became too damaged. Normally, when a cell is too damaged, it kills itself, but senescent cells don’t do that.

Instead of dying, they keep lingering around in the body; a zombie cell, so to speak.

Senescent cells secrete all kinds of substances that damage the healthy surrounding cells, like inflammatory substances (cytokines and chemokines), substances that break down the glue that holds the cells together (matrix metalloproteinases), and growth factors that accelerate aging (R).

Senescent cells play a considerable role in the aging process.

Not only do senescent cells damage healthy surrounding cells, but they also damage stem cells, which are the foundational cells that create new cells, which build up and repair our organs and tissues.

Reducing the senescent cell burden can lead to reduced inflammaging (low-grade inflammation that increases during aging) and enhanced function of stem cells.

Substances that can eliminate senescent cells are called “senolytics”. Fisetin is a well-studied senolytic substance.

Fisetin versus quercetin

Besides fisetin, another senolytic is quercetin. Quercetin and fisetin look very similar. However, fisetin seems to be the most potent and safest of natural senolytics (R):

Fisetin is far better in destroying senescent cells (red bar) than other substances, such as quercetin or curcumin or EGCG.Source image: Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine, 2018

The conclusion of the researchers was the following:

“Fisetin had the most potent senotherapeutic effects in several cell types in vitro and showed strong anti-geronic effects in vivo”.

Lifespan extension effects of fisetin

Scientists demonstrated that fisetin can extend median and maximum lifespan in mice, even when taken late in a mouse’s life (equivalent to 50 or 60 years old for a human) (R):

Fisetin extends  lifespan (red graph) versus control group (black graph) in mice. Source image: Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine, 2018

Another study showed that fisetin reduced the impact of aging in a mouse model of accelerated aging.

Old mice receiving fisetin were better in navigating a maze and in recognizing objects, which translates into improved cognition and memory:

Old mice that received fisetin (pink) were almost as good as young mice in object recognition and navigating a maze.Source: Fisetin Reduces the Impact of Aging on Behavior and Physiology in the Rapidly Aging SAMP8 Mouse. Journals of Gerontology, 2018

More than a senolytic: other anti-aging effects of fisetin

Fisetin has many other beneficial effects on the aging process besides eliminating senescent cells.

For example, fisetin inhibits the mTOR pathway (R), which plays an important role in aging and is where many of the health benefits behind fasting are derived. Fisetin can also reduce oxidative stress (R).

Fisetin can reduce inflammaging (aging-related low-grade inflammation) by inhibiting pro-inflammatory enzymes and substances, like lipoxygenases and NF-kB (R,R).

Interestingly, fisetin can also have various beneficial effects on the skin. For example, fisetin can reduce the formation of skin wrinkles and appearance of skin aging.

One way it can achieve this is by reducing the amount of matrix metalloproteinases (MMPs) (R,R). MMPs are enzymes that break down the extracellular matrix that surrounds our cells. The extracellular matrix consists of collagen, elastin, hyaluronic acid, glycosaminoglycans (GAGs), and many other molecules that glue the cells together, so that they can firm tissues (like the skin) and organs. An overactivity or overproduction of matrix metalloproteinases plays a role in wrinkle formation.

Fisetin also has a positive impact on brain functioning and brain aging (R). For example, fisetin can improve memory formation in mice (R,R).

Wisepowder CORE & fisetin

Fisetin powder is one of the core products in Wisepowder. Both bulk and huge amount are available from them.

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FISETIN: WHY ARE PEOPLE TAKING THIS SUPPLEMENT?

Fisetin is a flavonoid found in many fruits and vegetables. It has been shown to have anti-inflammatory, antioxidant, and anticancer effects. Because of the potential health benefits it may provide, fisetin supplements are becoming more popular as people look for alternatives to other medications that they may not be comfortable with or want to take long term. In this blog post we will explore what fisetin is, why people are taking it, potential benefits and discuss current research being done around Fisetin and how this could impact future treatments available for those looking to improve their health naturally.

Origins & History of Fisetin

Fisetin is a naturally occurring flavonoid compound. Flavanoids are water-soluble compounds found in plants and have antioxidant properties. Water-soluble means that Fisetin can dissolve in water. Fisetin is not found to be fat-soluble, which means it cannot dissolve into fats or lipids that are normally soluble in oils. Fisetin was isolated from the Fruiting bodies of a Fungus called Fomes Fomentarius. The Fruiting body of this fungus is responsible for producing all of the spores that are used to reproduce. Fisetin can also be found in many plants including Ginko Biloba, strawberries, persimmons. Fisetin’s chemical structure was first identified chemical formula was first described by Austrian chemist Josef Herzig in 1891. Fisetin can be found throughout the plant kingdom, where it acts as a photosynthesis inhibitor and UV protectant. Fisetin has even been isolated from insects, including ants, aphids, and wasps.

Fisetin is also said to be one of the many flavonoids that are found abundantly in the plant subfamily Cornoideae, which includes Foeniculum vulgare, Foeniculum dulce, and Coriandrum sativum. Fisetin was first isolated from Foeniculum vulgare, Fennel. Fisetin was first isolated from the bark of the Pacific wax myrtle tree and has since been found in many fruits and vegetables. Fruits and vegetables that are high in fisetin include:

– Strawberries; specifically, they are Fisetin’s highest food source.

– Red grapes

– Apples

– Asian pear

– Fennel seeds (Foeniculum vulgare) Fisetin is a member of the flavonoids, which are plant pigments produced by many plants to help protect themselves from outside stressors, such as ultraviolet light, insects, and herbivores.

Why are people taking Fisetin?

Natural supplements are becoming increasingly popular in the health and wellness community. There are a number of different types of natural supplements such as probiotics, prebiotics, digestive enzymes, amino acids and herbal extracts that all serve their own specific purposes. There are many reasons why people take natural supplements. Some people want to support their bodies’ natural processes, others want natural help with a specific health concern, and some just want to maintain good health. Dietary supplements have been one way that consumers have sought to fulfill unmet dietary needs. Fisetin is one of many supplements like this that people are turning to attempt to make themselves feel better. Many of my patients opt to take supplements to make sure they get enough essential nutrients and to maintain or improve their health.

POTENTIAL BENEFITS

Fisetin is a naturally occurring antioxidant found in many fruits and vegetables. Fisetin is known as a neuroprotective agent, meaning it has been shown to have potential benefits in helping the body fight against both acute and chronic neurological diseases. Fisetin is one of the most common and bioactive flavonoids which possesses potential neuroprotective effects. Fisetin also enhances learning and memory, decreases neuronal cell death, and suppresses oxidative stress. Fisetin has been shown to have significant protective effects on the body from oxidative stress, which is why Fisetin may be taking it as it can potentially be beneficial for those looking to improve their health or prevent disease. Oxidative stress refers to the level of damage done to cells in the body by free radicals. Fisetin has been shown to have some effect against oxidative stress, but it is not yet known whether Fisetin itself can actually reduce oxidative stress or if Fisetin can enhance antioxidants that are already present in the body. It is also unknown how Fisetin works as an antioxidant. Fisetin may work as a scavenger, Fisetin can bind to free radicals, Fisetin could be regenerating the antioxidants that it is acting with, or Fisetin itself may act as an antioxidant. There is still much to learn about Fisetin.

FISETIN AND LONGEVITY

As we age, we accumulate damaged cells. Damaged cells can cause tissues to function improperly or not work at all. Fisetin has been shown to reduce senescent cell burden in mice by activating the body’s enzymes that clear out senescent cells. Senescent cells are cells that have stopped dividing to replicate themselves. Senescent cells can accumulate in all tissues with age and secrete pro-inflammatory cytokines and chemokines. Fisetin has been shown to increase the lifespan of mice. In a recent study, Administration of fisetin to wild-type mice late in life restored tissue homeostasis, reduced age-related pathology, and extended median and maximum lifespan.

FISETIN & and mTOR

mTOR is responsible for controlling cell growth, division, and metabolism. Recent research shows how Fisetin inhibits the mTOR pathway. When you inhibit the mTOR pathway you are essentially slowing down the aging process.

Fisetin & Inflammaging

Inflammaging refers to the chronic low-grade inflammation that is caused by cellular damage, oxidative stress, and mitochondrial dysfunction. Fisetin is believed to be able to reduce inflammation because Fisetin has shown an ability to reduce cellular (nuclear) damage in animal studies. This is accomplished by Fisetin’s ability to inhibit by inhibiting pro-inflammatory enzymes and substances, like lipoxygenases and NF-kB.

FUTURE RESEARCH

As research continues on this compound more information about how fisetin could be used for medicinal purposes will be revealed. Fisetin holds great potential for multiple applications in medicine, and research studies have shown Fisetin’s positive anti-inflammatory and anticancer effects on different cell types. Over the last two decades, much attention has been drawn to plant-derived bioactive compounds as novel therapeutic agents for treatment of neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). The current research suggests that the benefits of Fisetin may be worth considering for those looking for natural options to improve their health.

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What are the benefits of Fisetin?

Fisetin benefits are quite a few, and they have all been seen on animal models. No research has been able to conclusively determine these benefits in humans as most studies are still in the clinical phase. The different benefits of fisetin include:

Anti-Aging

Aging of the body is marked by a net increase in senescent cells, that are no longer able to divide. These cells release inflammatory signals, which results in the complications of aging most commonly seen. Most age-related disorders are due to abhorrent inflammation in the body promoted by the senescent cells. Fisetin powder consumption targets these cells and removes them from the body, hence, reducing inflammation and slowing down the aging process.

Diabetes management

In animal models, fisetin supplement has been shown to reduce blood sugar levels significantly. This effect of fisetin comes from the flavonoid’s ability to increase insulin levels, increase glycogen synthesis, and decrease the liver’s ability to initiate gluconeogenesis. Basically, fisetin acts on every pathway in the body that results in glucose production and stops those while activating the pathways that either store or use up the glucose in the bloodstream.

Anti-Cancer

The anti-cancer effects of fisetin powder differ based on the type of cancer. In a study performed on prostate cancer, fisetin was able to reduce the growth of cancer by blocking testosterone and DHT receptors, which are important for the growth of prostate cancer. In another study where the cancer being studied was lung cancer, fisetin supplements were able to increase antioxidants in the blood that had been reduced by tobacco use. Fisetin was also able to reduce the growth of lung cancer by 67 percent on its own, and 92 percent when combined with a chemotherapy drug. When used in colon cancer, fisetin significantly reduced the inflammation associated with colon cancer. The study, however, did not mention any effect of fisetin on cancer growth.

Neuroprotective

When older rats with age-related decline in cognition were given fisetin supplement, there was a significant improvement in their cognitive skills and memory. In another study, animal models were exposed to neurotoxic substances and then given a fisetin supplement. The test subjects were found to have not experienced any memory loss due to the supplement. However, it is not known if fisetin can cross the human blood-brain barrier with the same efficiency as the mice blood-brain barrier.

Fisetin is also neuroprotective in the sense that it prevents the development of neurodegenerative disorders such as Alzheimer’s by reducing the accumulation of harmful proteins in the brain. Similarly, mice with ALS showed an improvement in their balance and muscle coordination after being given fisetin powder. They also experienced a prolonged life span than what was expected.

Cardioprotective

Researchers studied the effect of fisetin powder on the cholesterol levels of rats who were fed a high-fat diet. Total cholesterol and LDL levels were found to have decreased significantly whereas HDL levels almost doubled. The hypothesized mechanism through which fisetin rids the body of cholesterol is believed to be increased release of it into bile. The reduced cholesterol, overall, has a cardioprotective effect.

All these fisetin benefits point toward anti-aging and longevity of life which should be enough to promote more clinical studies so that the compound can be approved for medicinal use.

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Pure Fisetin Powder: A Dietary Antioxidant In Aging and Longevity

Fisetin is a common botanical polyphenol and flavonoid found in a wide variety of plants, fruits and vegetables including strawberries, apples, persimmons, onions and cucumbers. Fisetin is considered a plant pigment imparting many fruits and vegetables, such as strawberries, with their characteristic color and appearance. Fisetin has a very similar molecular structure as the more popular plant flavonoid and dietary supplement Quercetin. Unlike Quercetin, however, Fisetin may be a senolytic and perhaps one of the most powerful senolytics known.

Manufacture: Batch Production

Package: 1KG/bag, 25KG/drum

1.What is Fisetin?

2.The Mechanism Of Action of Fisetin: How does Fisetin work?

3.What food contains Fisetin?

4.What are the benefits of Fisetin?

5.Fisetin Vs Quercetin: is fisetin the same as quercetin?

6.Fisetin Vs Resveratrol: is fisetin better than resveratrol?

7.Fisetin and weight loss

8.How much fisetin should I take: The fisetin dosage?

9.What are the side effects of fisetin?

10.Fisetin powder and fisetin supplements online

Fisetin Chemical Base Information Base Information

Name: Fisetin Powder

CAS: 528-48-3

Purity: 65%，98%

Chemical name: 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one

Synonyms: 2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one , 3,3′,4′,7-Tetrahydroxyflavone ,5-Deoxyquercetin , Natural Brown 1 , CI-75620 , NSC 407010 , NSC 656275 , BRN 0292829 ,

Cotinin , 528-48-3 (anhydrous)

Molecular Formula: C15H10O6

Molecular Weight: 286.24

Melting Point: 330° C (dec.)

InChI Key: GYHFUROKCOMWNQ-UHFFFAOYSA-N

Form: Solid

Appearance: Yellow Powder

Half Life: /

Solubility: Soluble to 100 mM in DMSO and to 10 mM in ethanol

Storage Condition: −20°C for long time

Application: Fisetin is a potent sirtuin activating compound (STAC), antiinflammatory and anticancer agent

Testing Document: Available

Flavonoid polyphenols are commonly used for their antioxidant properties. Their main source is fruits and vegetables that are consumed regularly, by

millions worldwide. Due to their health benefits, flavonoids have also become key ingredients in different dietary supplements, especially resveratrol.

Recent studies have found a new flavonoid namely fisetin, which is believed to be the most potent among the other flavonoids used as a dietary

supplement. Fisetin powder or Fisetin supplements have since increased in demand due to their health benefits.

What is Fisetin?

Fisetin is a flavonoid polyphenol that acts as a yellow pigment in plants. Originally discovered in 1891, fisetin is found in many fruits and vegetables such

as persimmon and strawberries. Although it has been around for a long time, it was only recently that the fisetin benefits were discovered and made it

stand out compared to other supplements. Moreover, it was the potential medicinal benefits of fisetin powder that encouraged research into the topic.

Although it has been studied and the fisetic benefits and fisetin side effects have been realized, there is still a lot that scientists haven’t been able to

understand about the flavonoid.

The Mechanism Of Action of Fisetin: How does Fisetin work?

Fisetin powder works through multiple pathways in the human body. Fisetin especially works on the antioxidants levels in the body and this is one of its

major benefits. It fights against free radicals, which are unstable ions that will participate in harmful chemical reactions to harm the body. Fisetin’s

antioxidant properties allow it to neutralize these free radicals and hence, reduce the oxidative stress that the body is under.

Another mechanism of action of fisetin is that it blocks the NF-KB pathway. This pathway is important for the production and release of

pro-inflammatory cytokines and eventually, inflammation. NF-KB is a pro-inflammatory pathway that induces gene transcription to synthesize the

inflammatory proteins. When overtly activated, the NF-KB pathway plays an important role in cancer development, allergies, and autoimmune diseases.

Fisetin powder blocks this pathway, hence, acting as an anti-inflammatory supplement.

Fisetin powder also blocks the action of the mTOR pathway. This pathway, much like the NF-KB pathway, is involved in the development of cancer,

diabetes mellitus, obesity, and neurodegenerative diseases. mTOR pathway causes the cells to panic as they struggle to meet the energy demands of

the pathway, resulting in an excessive workload on the cells. What this means is that cells are overworking and producing metabolic waste but there

isn’t sufficient time to clean up the waste resulting in the accumulation of waste. This can be detrimental to cellular health and the blockage of this

pathway by fisetin supplement is how fisetin helps manage obesity, diabetes, and cancer.

Apart from these major mechanisms of action, fisetin is also able to inhibit the activity of lipid-degrading enzymes, lipoxygenases. It also inhibits matrix

metalloproteinases or the MMP family of enzymes. These enzymes are crucial for cancerous cells to be able to invade other tissues, however, with the

use of fisetin powder, that is no longer possible.

What food contains Fisetin?

Fisetin is a plant-based flavone that is primarily extracted from apples and strawberries. It is a pigment of yellow and ochre color in plants, meaning that

most fruits and vegetables of that color are rich in fisetin. Fisetin, in plants, is synthesized from the amino acid phenylalanine, and the accumulation of

this flavone in plants is highly dependent on the environment of the plant. If the plant is exposed to shorter wavelengths of UV rays, then there is an

increase in the production of fisetin. Fisetin powder is made from the isolation of fisetin from the following plant sources.

Plant sources Amount of Fisetin (μg /g)

Toxicodendron vernicifluum: 15000

Strawberry: 160

Apple: 26

Persimmon: 10.6

Onion: 4.8

Lotus root: 5.8

Grapes: 3.9

Kiwifruit: 2.0

Peach: 0.6

Cucumber: 0.1

Tomato: 0.1

What are the benefits of Fisetin?

Fisetin benefits are quite a few, and they have all been seen on animal models. No research has been able to conclusively determine these benefits in

humans as most studies are still in the clinical phase. The different benefits of fisetin include:

Anti-Aging

Aging of the body is marked by a net increase in senescent cells, that are no longer able to divide. These cells release inflammatory signals, which

results in the complications of aging most commonly seen. Most age-related disorders are due to abhorrent inflammation in the body promoted by the

senescent cells. Fisetin powder consumption targets these cells and removes them from the body, hence, reducing inflammation and slowing down the

aging process.

Diabetes management

In animal models, fisetin supplement has been shown to reduce blood sugar levels significantly. This effect of fisetin comes from the flavonoid’s ability

to increase insulin levels, increase glycogen synthesis, and decrease the liver’s ability to initiate gluconeogenesis. Basically, fisetin acts on every pathway

in the body that results in glucose production and stops those while activating the pathways that either store or use up the glucose in the bloodstream.

Anti-Cancer

The anti-cancer effects of fisetin powder differ based on the type of cancer. In a study performed on prostate cancer, fisetin was able to reduce the

growth of cancer by blocking testosterone and DHT receptors, which are important for the growth of prostate cancer. In another study where the

cancer being studied was lung cancer, fisetin supplements were able to increase antioxidants in the blood that had been reduced by tobacco use.

Fisetin was also able to reduce the growth of lung cancer by 67 percent on its own, and 92 percent when combined with a chemotherapy drug. When

used in colon cancer, fisetin significantly reduced the inflammation associated with colon cancer. The study, however, did not mention any effect of

fisetin on cancer growth.

Neuroprotective

When older rats with age-related decline in cognition were given fisetin supplement, there was a significant improvement in their cognitive skills and

memory. In another study, animal models were exposed to neurotoxic substances and then given a fisetin supplement. The test subjects were found to

have not experienced any memory loss due to the supplement. However, it is not known if fisetin can cross the human blood-brain barrier with the

same efficiency as the mice blood-brain barrier.

Fisetin is also neuroprotective in the sense that it prevents the development of neurodegenerative disorders such as Alzheimer’s by reducing the

accumulation of harmful proteins in the brain. Similarly, mice with ALS showed an improvement in their balance and muscle coordination after being

given fisetin powder. They also experienced a prolonged life span than what was expected.

Cardioprotective

Researchers studied the effect of fisetin powder on the cholesterol levels of rats who were fed a high-fat diet. Total cholesterol and LDL levels were

found to have decreased significantly whereas HDL levels almost doubled. The hypothesized mechanism through which fisetin rids the body of

cholesterol is believed to be increased release of it into bile. The reduced cholesterol, overall, has a cardioprotective effect.

All these fisetin benefits point toward anti-aging and longevity of life which should be enough to promote more clinical studies so that the compound

can be approved for medicinal use.

Fisetin Vs Quercetin: is fisetin the same as quercetin?

Quercetin and Fisetin are both plant flavonoids or pigments that are well known for their anti-inflammatory and anti-oxidant properties. They both also

have significant anti-aging properties, which they perform by clearing senescent cells from the body. Fisetin powder, however, has been shown to clear

out the cells with increased efficacy and potency than quercetin.

Fisetin Vs Resveratrol: is fisetin better than resveratrol?

Resveratrol is a polyphenol that is also quite popular for its anti-oxidant properties. Taking quercetin and resveratrol results in a synergistic effect on the

body, although quercetin is more potent at mediating inflammation and managing insulin resistance. Since Fisetin is better at performing these

functions than quercetin, it can be concluded that fisetin supplement is better than resveratrol supplements.

Fisetin and weight loss

Researchers studied the effect of fisetin powder on fat accumulation in the body and it was found that it blocks certain pathways to reduce diet-related

obesity. It targets the mTORC1 signaling pathway. This pathway is important for cell growth and lipid synthesis, hence, inducing fat accumulation in the

body.

How much fisetin should I take: The fisetin dosage?

Fisetin dosage ranges between 2 mg to 5 mg, per kilogram of weight, however, this is not the recommended guideline for the dosage. There is no

specific dosage recommendation for fisetin usage, and speaking to a medical professional would help in determining a fisetin dosage range, specific to

one’s own conditions. In one of the studies conducted with the purpose of assessing the effect of fisetin powder on inflammation caused by colon

cancer, 100 mg per day was required to notice a significant reduction in inflammation.

What are the side effects of fisetin?

Fisetin only recently became the subject of multiple studies and different pieces of research. This late interest in the flavonoid means that most studies

performed have been on animal models or in a lab setting. Not many human studies have been performed to conclusively determine the potential side

effects and toxicities of the supplement. Animal models on exposure to high doses of fisetin supplement did not show any adverse effects, pointing

towards the safety of the supplement.

However, it is important to remember that lack of side effects in animal models does not mean that the risk of side effects in humans does not exist. To

reach that conclusion, more clinical studies need to be performed. In one study that was performed on cancer patients to assess the efficacy of fisetin

powder in managing the symptoms of cancer, both placebo and control groups reported gastric discomfort. Since the side effect was present in both

groups, and both groups were undergoing chemotherapy at the same time, it is hard to conclude that fisetin powder consumption can cause gastric

discomfort.

Fisetin powder may not have any reported side effects but it does interact with certain drugs, resulting in altered metabolism of those drugs. Fisetin

was found to reduce the blood sugar levels in animal models, which is quite a benefit on its own. But when taken in conjunction with anti-diabetic

medications, the glucose-reducing effect of both, the supplement and the drug could be exaggerated. This could result in several health complications.

Fisetin powder is metabolized by the liver, in the same way, that blood thinners are metabolized. Due to this, it is hypothesized that these two would

interact with each other and Fisetin powder would increase the effects of blood-thinning agents.

Fisetin powder and fisetin supplements online

Fisetin powder can be bought online from different fisetin powder manufacturers, in quantities based on the specific need. Buying fisetin bulk amounts

can help with the pricing as well. Fisetin’s price is not that out of range, and it is in the same range as other flavonoid supplements.

When looking to buy a fisetin supplement, it is important to thoroughly look through fisetin powder manufacturers and their manufacturing process.

This is to ensure that proper safety guidelines and manufacturing protocols are followed during the production of the fisetin supplement. It is crucial to

buy pure fisetin powder as it makes for the best fisetin supplement. If the supplier does not follow safety protocols in the extractions and synthesis of

fisetin, the end-product can be contaminated or tainted with ingredients that are either harmful to human health or have no effect on human health,

whatsoever. Either way, the fisetin benefits would not be experienced despite taking the supplement for a long time.

It is always important to look into the ingredients of the fisetin powder being purchased and the concentration ratio of these ingredients to ensure that

pure fisetin powder is being purchased. If this distinction is not made, then there is a huge likelihood of increased fisetin side effects and/or reduced

fisetin benefits, overall.

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527824/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261287/

https://pubmed.ncbi.nlm.nih.gov/29275961/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780350/

https://link.springer.com/article/10.1007/s10792-014-0029-3

https://pubmed.ncbi.nlm.nih.gov/29541713/

https://pubmed.ncbi.nlm.nih.gov/18922931/

https://pubmed.ncbi.nlm.nih.gov/17050681/

https://pubmed.ncbi.nlm.nih.gov/29559385/

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Pure Fisetin Powder: A Dietary Antioxidant In Aging and Longevity

Pure Fisetin Powder: A Dietary Antioxidant In Aging and Longevity

Flavonoid polyphenols are commonly used for their antioxidant properties. Their main source is fruits and vegetables that are consumed regularly, by millions worldwide. Due to their health benefits, flavonoids have also become key ingredients in different dietary supplements, especially resveratrol. Recent studies have found a new flavonoid namely fisetin, which is believed to be the most potent…

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99.9% Pure Raw Nootropics supplement powder China Factory Buy In Bulk Wisepowder in 2022 Popular sell

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 99.9% Pure Raw Nootropics supplement powder China Factory Buy In Bulk Wisepowder in 2022 Popular sell 

Wisepowder is focusing on the research, manufacturing and innovation of raw materials for nootropics, nutritional supplements and pharmaceutical ingredients. We are a professional and experienced manufacturer and supplier. Wisepowder is a well-known and reputable company with over 20 years of experience in Chinese nutraceutical industry. And, at present, all the production of ingredients has a standard quality control management system which is in strictly accordance with GMP regulations. 

WISEPOWDER provides top quality products. And, one team we cooperated with locates in U.S. will provide related service for our clients around the world. Wisepowder has set up a laboratory center equipped with imported advanced instruments from Germany, Japan and U.S. for analysis and synthesis of the content of active ingredients which ensure Wisepowder controlling all stages of the manufacturing process. 

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Astragaloside IV  50%   84687-43-4 

Astragaloside IV  98%   84687-43-4 

Cycloastragenol (CAG) 50%   78574-94-4 

Cycloastragenol (CAG) 98%   78574-94-4 

Diosmetin 520-34-3 

EUK-134 81065-76-1 

 Glucoraphanin 30%  21414-41-5 

Hydroxypinacolone Retinoate(HPR)  98% 893412-73-2 

L-(+)-Ergothioneine (EGT)  purity 98%  497-30-3 

beta-Diphosphopyridine nucleotide(NAD+)  98% 53-84-9 

Beta-Nicotinamide Mononucleotide(NMN) 1094-61-7 

Pyrroloquinoline quinone disodium salt (PQQ disodium salt) 122628-50-6 Pyrroloquinoline quinone (PQQ)    72909-34-3 

Resveratrol 98%  501-36-0 

DL-Sulforaphane 1%,10% 142825-10-3 

Urolithin A 1143-70-0 

Urolithin B 1139-83-9 

5a-hydroxy Laxogenin 56786-63-1 

6-Paradol  50% 27113-22-0 

7,8-DHF/ 7,8-Dihydroxyflavone/7,8-Dihydroxyflavone Hydrate/Tropoflavin 38183-03-8 

Alpha GPC  50% 28319-77-9 

Alpha GPC  99% 28319-77-9 

Anandamide (AEA)  50% (powder form) 94421-68-8 

Anandamide (AEA)  85% (liquid form) 94421-68-8 

Aniracetam 72432-10-1 

Cetilistat  282526-98-1 

Coluracetam 135463-81-9 

Compound 7P 1890208-58-8 

Dehydroepiandrosterone(DHEA) 53-43-0 

Dihexa/PNB-0408   1401708-83-5 

Emoxypine (2-ethyl-6-methyl-3-hydroxypyridine) 2364-75-2 

Fasoracetam 110958-19-5 

glutathione (GSH) 70-18-8

IDRA-21  22503-72-6 

Lithium Orotate  5266-20-6 

Magnesium L-threonate 98%  778571-57-6 

Magnesium Taurate 334824-43-0 

 MK677(mesylate salt) Ibutamoren 159752-10-0 

N-Acetyl-L-cysteine ethyl ester (NACET) 59587-09-6 

N-AcetylneuraminiC ACID(SIALIC ACID)  131-48-6 

Nefiracetam 77191-36-7 

Nicotinamide Riboside Chloride (NR)  23111-00-4 

Nooglutyl 112193-35-8 

Noopept/GVS-111  157115-85-0 

NSI-189 Phosphate 1270138-41-4 

oleoylethanolamide(OEA) 85% 111-58-0 

oleoylethanolamide(OEA) 98% 111-58-0 

Olivetol（3,5-hydroxypentylbenzene） 500-66-3

 Palmitoylethanolamide(PEA) 544-31-0 

Phenethyl caffeate 104594-70-9 

Phosphatidylserine (PS) 70%  51446-62-9 

pinoline 20315-68-8 

Pramiracetam 68497-62-1 

PRL-8-53 51352-87-5 

Pterostilbene 99% 537-42-8 

Tianeptine hemisulfate monohydrate (THM) 1224690-84-9   

 Tianeptine 66981-73-5 

Tianeptine sodium 30123-17-2 

Unifiram/DM232 272786-64-8 

1-(Adamantane-1-carbonyl)-pyrrolidine-2-carboxylic acid 35084-48-1 Cannabidiol(CBD) 99%土2%  13956-29-1 

COENZYME Q10 40% 303-98-0 

COENZYME Q10 98% 303-98-0 

Gamma-aminobutyric acid (GABA)    56-12-2 

HBT1  489408-02-8 

Lycopene 3%    502-65-8 

Sesamin 98% 607-80-7 

Sesamol  533-31-3 

 Spermidine 98%  (liquid form) 124-20-9 

Spermidine trihydrochloride 98%    334-50-9 

Wheat Germ Extrac Powder（Spermidine）1% 124-20-9 

Zinc picolinate 17949-65-4

[wisepowder]

99 9% pure NMN powder China factory in bulk price buy Nicotinamide Monon.

Why We Need Nicotinamide Mononucleotide(NMN)

Although aging is inevitable, there are prospects of reversing the process, thanks to Nicotinamide Mononucleotide (NMN). Living to a ripe old age is everyone’s dream and there are compounds such as NMN which assists us achieve the dream.I know you are probably wondering how this compound correlates with aging. Well, hold your guns because I’ll be taking you through the nicotinamide mononucleotide benefits.Nicotinamide Mononucleotide (NMN) is a NAD+ precursor. NAD+ is a significant biomarker in the human cell. As we get on in years, this chemical declines as a result of several enzymatic functions. What’s more, the rate of consumption is always indirectly proportional to the degree of production.One significant thing to note is that, unlike most anti-aging treatments that leave you with insufferable symptoms, NMN side effects are next to null. Allow me to shed some light on how NMN impacts your lifespan.

What Is Nicotinamide Mononucleotide(NMN)

Nicotinamide Mononucleotide (Nmn) powder (1094-61-7) derives from niacin.  It is a product from the reaction between nicotinamide ribose and a phosphate group. The compound plays a significant role in the biosynthesis of NAD+ (nicotinamide adenine dinucleotide), which is quite fundamental in the cellular biochemical functions.

In the synthesis of NAD+, Nicotinamide Mononucleotide bulk powder acts as a substrate for nicotinamide mononucleotide adenylyltransferase, which is an enzyme responsible for converting it to NAD+.

NMN is among the major sources of cellular energy within the human body. Since it is a precursor of NAD+, the decline in one compound will drastically affect the other.

In the recent preclinical studies, Nicotinamide Mononucleotide has confirmed to be of the essence within the therapeutical domain. One notable breakthrough was the realization of the compound’s enormous role in reversing senescence and holding back the aging process.

Recently, there is promising research about nicotinamide mononucleotide cancer management.

What Foods Contain Nicotinamide Mononucleotide(NMN)

Broccoli

Cabbages

Edamame

Mushroom

Tomatoes

Avocado

Cucumber

Shrimp

Raw Beef

Wisepower has a large-scale production capacity of NMN and NR powder, monthly production capacity up 2,000KG.

What Are The Benefits Of Nicotinamide Mononucleotide(NMN)

Anti-Aging Supplement

You will agree with me that old age and gray hair are synonymous with wisdom. However, the joy of this maxim is short-lived when you start having senior moments. As we advance in years, our bodies transform into a magnet of diseases.

Old age leaves a great impact on cellular functions. For instance, the levels of NAD+ and Nicotinamide Mononucleotide considerably fall back during the golden years. Although the body still synthesizes the chemical, the rate of consumption maximumly surpasses the frequency of regeneration.

In the case of DNA damage, NAD+ activates the PARP1, a DNA-repairing protein, to restore the affected organelles.

A decrease in NMN affects the NAD+ levels and subsequently leads to a decrease in energy production by the mitochondria.

Research studies by Dr. Sinclair, a geneticist from Havard University, confirm the efficiency of nicotinamide mononucleotide supplement in slowing down aging. The scholar admits that he and his dad are taking the supplement and it certainly improves memory and sharpens their mind.

Treatment of Diabetes II

A decline in the level of nicotinamide adenine dinucleotide may trigger type II diabetes.

Administering Nicotinamide Mononucleotide would significantly improve glucose intolerance and insulin sensitivity in patients with diabetes. Besides, some geneticists inferred that the treatment reverses the gene expression that’s due to a high-fat diet.

Neuroprotection

When the levels of nicotinamide adenine dinucleotide fall,  the mental state lies at stake.

Administering NMN optimizes the quantity of NAD+, hence protecting the brain from damage. In a nutshell, Nicotinamide Mononucleotide benefits neuronal functions and cognition, including, learning, and memory.

For this reason, the treatment is used to manage Alzheimer’s disease, Parkinson’s syndrome, dementia.

A certain study vouches for the above nicotinamide mononucleotide benefits by confirming that the supplement efficiently deals with intracerebral damage. When researchers administered the dose on old mice, the subjects registered massive improvement in the production of intracerebral NAD+. As a result, there was a subsequent reduction in ischemic stroke and neurological inflammation.

Improved Metabolism

Optimum NMN level in the body translates to an increase in NAD+, which regulates energy metabolic functions, repair of DNA, and response to stress. Since Nicotinamide Mononucleotide directly affects metabolism, its deficiency would trigger several metabolic conditions like obesity, diabetes, fatty liver, and dyslipidemia.

In the case of glucose intolerance, NMN steps in to enhance the metabolism of sugar.

Research confirms that you can lose up to 10% of your bodyweight if you take NMN. As Dr. Sinclair put it, the impact of a single NMN dosage for humans is equal to running on a treadmill.

Upholding Youthfulness

Forget about the tons of makeup kits and facial surgery that leave you with insufferable upshots.

As scientists put it, we are as old as our arteries. With this remark, you can infer that reversing the vascular atrophy and senescence of our blood vessels will play the trick in our lifespan.

What mainly separates youthfulness from old age is vitality and muscle endurance. Although all these characteristics improve with regular exercises, senescence defies the odds and the muscular tissues weaken while blood flow declines within these systems.

Allow me to explain from a scientific perspective. When the human endothelial cells suffer a decline in Sirtuin1 proteins, blood flow will drastically fall. You should understand that NMN is the key regulator of SIRT1. Therefore, administering this supplement will activate sirtuin-signaling, which will generate new capillaries to supply oxygen and nutrients to the muscles and other vital organs.

NMN Vs NR

So, what is it all about nicotinamide mononucleotide vs riboside?

Well, both are precursors of NAD+.

A glance through their chemical structures will tell you that NMN has a bigger molecular size than NR. Thus, nicotinamide riboside can make it through the human body without the need for breaking down its whole molecule.

However, there is a glimpse of hope when a recent study confirmed there is a mysterious transporter that allows the chemical to pass through the digestion process. Earlier studies brushed off this possibility until some scientists discovered the Scl12a8 protein, which facilitates the conversion of NMN to nicotinamide adenine dinucleotide.

Most users find nicotinamide mononucleotide price to be slightly higher than that of its riboside counterpart.

Wisepower has a large-scale production capacity of NMN and NR powder, monthly production capacity up 2,000KG.

Nicotinamide Mononucleotide(NMN) Research

Although there are numerous research studies and intense NMN supplement review since its discovery in 1963, please allow me to touch on the notable projects.

NMN Upholds Youthfulness

Since 2013, Dr. Sinclair has been actively involved in studying the Nicotinamide Mononucleotide supplement and its role as an anti-aging supplement. In his research paper, the geneticist noted that the treatment improved the muscle capacity and metabolism of the mice models. Dr. Sinclair compared the efficiency of NMN to working out.

Through the research, this Harvard geneticist did not record NMN supplement side effects.

Cardio-protective Role of NMN

In a 2014 NMN supplement research, Yamamoto and his associates determined that NMN has cardio-protective properties. Administering the supplement will shield the heart from reperfusion and ischemic injury.

Two years later, De Picciotto and his fellow geneticists found out that NMN could promote vascular functionality.

NMN Combats Neurodegeneration

In 2015, Long and his crew noted that NMN supplement could treat Alzheimer’s and reduce its negative symptoms. A year later, Wang and his team of scientists concluded that the treatment would counter cognitive disorders and neural impairment.

In subsequent years, NMN supplement research scientists have come up to endorse the efficacy of Nicotinamide Mononucleotide in improving the cognitive functions.

NMN Promotes Physiological and Immunological Functions

In 2013, Mills and his team found out that nicotinamide mononucleotide (NMN) could manage type II diabetes. Three years later, he established that the supplement counters physiological and immunological decline in old mice. In the same year, Mills teamed up with Yoshino and Imai to study how NMN affects vascularity and its role in oxidative stress.

NMN Mysterious Transporter

Imai and a team of biochemists discovered Slc12a8, which aids in the assimilation of Nicotinamide Mononucleotide into the body. The process is rapid and it would least affect the NMN bioavailability.

Clinical Trials

Since 2017, Scholars from Keio (Tokyo) and Washington Universities have been actively involved in the clinical trials of NMN among the aged but healthy subjects.

The objectives of these human trials are to establish the safety of nicotinamide mononucleotide and to understand how the supplementation affects the beta-cell functions. Besides, the research scientists have wanted to ascertain if there were any NMN supplement side effects.

Nicotinamide Mononucleotide(NMN) Dosage

Probably the question racing through your mind is, “How much NMN should I take?” Well, let me break it down to you.

A typical NMN dosage for humans is about 25mg and 300mg per day. In all the available clinical trials, the subjects would take a maximum of 250mg/day.

Dr. Sinclair confesses that he takes about 750mg of NMN per day. If you scheme through the online NMN supplement review, you’ll realize that some users go up to 1000mg/day. Although there are no known records of nicotinamide mononucleotide side effects, you should stick to the lowest dose as possible.

Is Nicotinamide Mononucleotide(NMN) Safe

So far, there is no data to indict Nicotinamide Mononucleotide as unsafe. From the records published during the clinical trials, no subject had registered any grave nicotinamide mononucleotide side effects. What’s more the preclinical studies were successful without recording any adverse symptoms.

Wisepower has a large-scale production capacity of NMN and NR powder, monthly production capacity up 2,000KG.

Nicotinamide Mononucleotide(NMN) Supplement

Since nicotinamide mononucleotide has not received a full endorsement by the FDA, it cannot be a prescription drug. However, you can take it as a dietary supplement.

Although you can find it in local drug stores, the ideal place to purchase the product is online. You can buy nicotinamide mononucleotide bulk powder for your research or go for the dietary supplement. However, make ensure you are shopping from a legit beta-nicotinamide mononucleotide supplier.

To increase the NMN bioavailability, you should prefer sub-lingual pills rather than oral tablets.

According to FDA standards, a person needs at least 560mg of Nicotinamide Mononucleotide per day. What you ought to know is that broccoli and cabbage register the highest quantities of NMN compared to other foods and fruits.

For instance, broccoli contains between 0.25mg and 1.12mg of the chemical. Thus, if you want to maintain a healthy status and heed to the FDA requirements, you’ll have to consume 1500 pounds of broccoli in a day. Since doing so is incredibly impossible, you should opt for buying the supplement from a beta-nicotinamide mononucleotide supplier.