#NoTumorsAllowed

What did one cell say to his sister cell when she stepped on his toe? "Mitosis!"

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Adenomatous polyposis coli tumour suppressor by The Royal Society

“Most cases of colorectal cancer are linked to mutational inactivation of the Adenomatous polyposis coli (APC) tumour suppressor. Here Buchi Okereafor talks to author Mariann Bienz about her Open Biology paper "The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled" and the role APC plays in the development of colorectal cancer.”

[adenomatouspolyposiscoli]

APC Mutations generally happen during the early stages of colon cancer. Any mutations in APC lead to loss of β-catenin regulation, altered cell migration and chromosome instability. FAP and other APC mutations are inherited, there are extremely rare cases when an outside cause leads to an APC mutation, however they are generally hereditary.

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[adenomatouspolyposiscoli]

Above is a diagram of the cell cycle regulation. During the cell cycle, APC is mainly required to induce progression and exit from mitosis by inducing proteolysis of different cell cycle regulators. It contains its own catalytic core, but substrate recognition by APC is mediated by the APC activators.

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[adenomatouspolyposiscoli]

Did you know?

The APC gene is a tumor suppressor. 

It suppresses canonical Wnt signaling, which is essential for tumorigenesis, development and homeostasis. Further studies have suggested that APC plays roles in several other fundamental cellular processes. These include cell adhesion and migration, organization of the actin and microtubule networks, spindle formation and chromosome segregation.

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[adenomatouspolyposiscoli]

Here's some statistics about colon cancer!

Source 

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When you find out you have Colon Cancer.

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What chromosome is APC on?

It is on Chromosome 5 and located in animal cells.

[adenomatouspolyposiscoli]

CANCERS ACCORDING TO YOUR SIGN

Aries: Colon Taurus: Throat Gemini: Brain Cancer: Mouth Leo: Lung Virgo: Ovarian Libra: Breast Scorpio: Pancreatic Sagittarius: Skin Capricorn: Bone Aquarius: Blood Pisces: Eye

[vmartineau]

An animal cell.

[adenomatouspolyposiscoli]

Did you know?

That APC is the only gene that scientists have found that causes FAP (familial adenomatous polyposis). It is difficult to track fbecause there are 300 different mutations in the APC gene. If an individual develops FAP, polyps will appear in their colon and people who inherent mutations in this gene have a 100% chance of developing colon cancer by the time they reach 40. 

The picture is a patient from the University of Dundee's polyp seen on a microscope.

[adenomatouspolyposiscoli]

Experimental Ideas for Finding Hereditary Colon Cancer

Researchers have found an easier test that may come to use in common practice in an estimated time span of 3-5 years. This test looks for the presence of cancer cells of the ATP mutation inside of an individual's stool samples.

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