I had to cancel my girls trip this weekend for many reasons. Work. My kids and their many activities. Not wanting to socialize with people who are republicans. And then, my dad fell and broke his hip.
Managing aging parents is going to be an ongoing challenge for me. My brothers are both out of town and not helpful. My parents are stubborn and want the most frugal method, without any concern to how that affects others. My mother is highly sensitive and takes any sort of help as a personal attack. But then will complain endlessly like the martyr she is. It is exhausting.
I'm trying really hard to bite my tongue and offer support, in person, with specific tangible things. But, being on the receiving end of a narcissist's ire is a losing battle. I am exhausted.
This semester I taught 4 classes in addition to my normal 3 day a week job. This meant working 1.5 jobs all semester and it was as terrible as it sounds. Except it was a new course so I had nothing to use and had to design the curriculum too.
ANYWAY! Today was my last day of classes. I did it. I made it to winter break.
In 2026 I will ‘just’ do my normal job and they asked me to re-write the curriculum since my class went so well, it’s becoming a mandatory course for freshmen. So I will become full time, but just normal full time. Not like working 2 jobs overextended.
It is December SEVENTEETH, Christmas is one week away, and today the Mister made himself a to-do list that includes calling his siblings to see what their kids want for presents.
Babe. I already texted the niblings directly, bought the things they wanted, wrapped most of them, and updated a color coded spreadsheet about it.
I’m irrationally annoyed that my daughter’s pin is upside down in her school photos.
There are special pins given to students who win a Mercy Spirit or religion award at the end of the year. You get to wear it on your uniform for the following year.
Another girl in her class forgot her pin, and her mom is a teacher. They borrowed G’s pin for picture day and then put it on G upside down, which is how it was photographed.
I have three major birthdays during the first week of school: my daughter, my husband, my dad. As a teacher myself, this is a lot for the first week!
We had a party at our house this weekend for L's friends. She had some older sisters of one of her classmates lead her friends in a series of sporty stations. My friend made a candy wall and the girls decorated canvas bags for their little favor.
All in all it was a success but I would loooooove a chill weekend one of these days!
LOL my kids are playing soccer, flag football, cross country, and swim (x2) this fall. No rest for me!
Three changes in total to the genetic code were needed to ensure the transplanted donor cells didn't trigger an immune response.
"A patient with type 1 diabetes has become the first in the world to produce his own insulin via transplanted cells edited with CRISPR.
The edits halted his own immune system from attacking the cells, leading to production of insulin in the pancreas as if he never had the disease in the first place.
Unlike the rampant type 2 diabetes, type 1 manifests as an autoimmune disorder whereby the patient’s immune system attacks and destroys a type of cell created in the pancreas to produce insulin, known as islet cells. 9.5 million people worldwide suffer from type 1 diabetes and there is no cure.
The standard of care beyond daily insulin injections involves using donated islet cells to allow a patient’s metabolism to function normally, followed by medications used to prevent the immune system from attacking those cells. These medications have harmful side effects.
A team of biomedical researchers primarily from Uppsala University, Sweden, in collaboration with UC San Francisco, successfully used the CRISPR gene-editing method to take a donor’s islet cells and modify them so as to evade prosecution by the patient’s immune system.
Three changes in total to the genetic code were needed to ensure the transplanted donor cells didn’t trigger an immune response, including changes to cell membrane signal proteins used as a sign of attack by white blood cells.
CRISPR TO THE RESCUE:
Infant With Incurable Disease is First to Successfully Receive Personalized Gene Therapy Treatment
Aggressive Leukemia Disappears in 13-Year-old Girl Who was First to Receive New CRISPR Treatment
First Patient to Receive Gene Therapy ‘Cure’ for Beta-Thalassemia Living Pain-Free
As a preliminary study, the man received only a small amount of the donated, modified cells, meaning he still requires daily insulin injections. However the results show that the cells produced their own insulin and remained unperturbed by the immune system.
After 12 weeks, the cells were still producing endogenous insulin, setting the stage for longer-term and more robust experiments in the future.
The study was published in the New England Journal of Medicine."
We are home for LDW and getting a million things done around the house before school starts. Today I took L shopping for some fall clothes and we realized that I had never taken just her on a clothes shopping trip. We tried things on! She is my child that never wants me to spend money on her and cares little about clothes. We found a bunch of tops and bottoms for her to mix and match that we both agreed on. As we walked out she said, ‘I didn’t think I was going to like this, but I actually really had fun!’
They let me use a coupon and my teacher discount too; my mom would be proud!
I have a lot of students on the soccer team this year so I took my kids to the home opener today. We had so much fun! I played soccer at my high school and I haven’t watched a game since then. We have gone to many other sports and concerts and the plays at my school, but not soccer. It was SO great to share with my kids even though 2/3 of them have already opted out of the sport. Definitely team: not trying to recreate my own childhood but also had a fun afternoon sharing a memory.
Did you ever go a party in your teenage years? Only parties with mostly people of your age count (so, no work-related party if you had a job and no baby showers, for instance), and birthdays don’t
Yes, often
Yes, up to a few times
No, never
Infinitely nuanced answer
Did you ever go a party in your teenage years? Only parties with mostly people of your age count (so, no work-related party if you had a job and no baby showers, for instance), and birthdays don’t
Yes most weekends! I went to an all girls school so seeing our boy friends (and boyfriends) took place on the weekends, and I had a fun group of friends. Sorry I’m fun!!!!!!!
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