The machine combines the technology of both cryotherapy and electrophoresis. Just hearing the word cryo might chill you down, as it means ice cold or low temperature. The stable -15 degrees celsius temperature of the machine rapidly cools the skin, causing constriction of the small blood vessels, followed by vasodilatation due to release of transmitter substances. This enables the serums to be pumped into the skin. Electrophoresis, on the other hand, works on the principle that the charged particles of a product migrate in an applied electrical field. Skin treatments penetrate the lipid bilayer membranes by applying voltage pulses.