Bromantane

[bromantane]

Sunifiram, pure chemical ≥ 99%. 1000mg.

Sunifiram is a nootropic in action superior to classic Piracetam.

Sunifiram

Purity: ≥ 99%

Net Massa: 1000mg.

CAS No.: 314728-85-3

Manufacturer: Nonsensia

Chemical formula: C14H18N2O2

Molar mass: 246,310 g-mol-1

Sunifiram is also known as DM-235.

We offer pure Sunifiram without any fillers. Which may come as a surprise to many of you.

The offered Sunifiram was synthesized in our Polish laboratory, which we are proud of!

The product was tested by chromatography and spectrography. It does not contain heavy metals.

The sunifiram you buy is for laboratory testing only not for consumption!

 More detailed information regarding Sunifiram can be found here:

https://noopept.us/sunifiram-mechanizm-dzialania-i-dawkowanie/

http://methylene-blue.myshopify.com/products/sunifiram-pure-chemical-99-1000mg

[bromantane]

Noopept / НООПЕПТ. Synthetic substance ≥ 99% 1000MG.

Noopept. A cousin of piracetam with more than a thousand times stronger effects. It has a documented pro-cognitive effect. Improves the process of information assimilation. Transforming information from short-term to long-term memory.

Noopept 1000mg

  Noopept purity ≥ 99%

Net weight: 1gram

Cas No. : 157115-85-0

Molecular Formula: C17H22N2O4

Molecular weight: 318.37

Use: Product for laboratory testing not for consumption.

  Other chemical names:

Glycine, 1-(2-phenylacetyl)-L-prolyl-, ethyl ester

Glycine, 1-(phenylacetyl)-L-prolyl-, ethyl ester

Glycine, N-[1-(phenylacetyl)-L-prolyl]-, ethyl ester

1-(2-Phenylacetyl)-L-prolylglycine ethyl ester

1-(2-Phenylacetyl)-L-prolylglycine ethyl ester

Noopept - what is this molecule?

Ноопепт is a Russian agent with broad nootropic effects. Noopept, is the ethyl ester of N-phenylacetyl-L-prolylglycine. Other names for this formulation include; GVS-111, Nupept and Zynapse. The Ноопепт molecule was developed and patented in Russiai. The Russian pharmacological institute has a number of substances characterized by pro-cognitive effects in its achievements. Nootept is often paired with piracetam. In favor of Noopept is the nearly 1,000-fold stronger effect of this agent compared to piracetam. For users, this means a significantly reduced dosage of the substance with a concomitantly increased action profile.

As a so-called smart-drug with nootropic effects, the agent perfectly supports cognitive processes including concentration. In addition, it exhibits a multifaceted spectrum of neuroprotective activities. Noopept has a moderate anti-anxiety effect. After administration, it is converted to cycloproliloglycine.

Noopept - potential uses of the substance.

Ноопепт-as a drug with nootropic and neuroprotective effects-is used by people who want to raise the bar of their mental activity. It is especially recommended for students. The product significantly improves cognitive functions. Improved concentration, improved ability to assimilate knowledge are the main features of Ноопепт. Consumption of this molecule is accompanied by an overall improvement in well-being. The preparation may have a moderate anti-anxiety effect. To a lesser extent, it also has an anti-depressant effect. Nootept stabilizes the body's response to stressful situations. Noopept reduces fatigue and supports the immune system. It has multifaceted applications, especially in supporting the treatment of diseases that lead to neurodegeneration of the brain. It has been successfully tested in Alzheimer's and Parkinson's disease patients.

Nootept's mechanism of action and profile.

The Noopept molecule exhibits several basic pathways of action on the human body. First of all, it increases the sensitivity of neurons to acetylcholine. Thus, it improves the conduction of electrical charge (information) between neurons. The consequence of increased acetylcholine availability is improved memory. This is due to the transformation of short-term memory, consolidating it into long-term memory. The mechanism is done by increasing neurotrophic factors in the brain. Studies show increased hippocampal activity after Nootept administration. Improves neuroplasticity of connections between neurons. The overall holistic effect of the substance translates into more efficient brain function.

How to dose the product?

The recommended and confirmed human dosage of Noopept is from 10-30mg. Pryparat should be taken one to three times a day. It is not recommended to exceed the daily dose. The recommended daily dose is up to 60mg of the active substance. Spectacular results are achieved by combining Nootept with other agents that improve the work of synapses. Nootept, in combination with choline or Alpha GPC, brings the benefits of improved memorization and consolidation of information in long-term memory.

More detailed information regarding Noopept:

https://noopept.us/noopept-kiedy-stosowac-jak-dawkowac/

  References:

Kondratenko R., Derevyagin V., Skrebitsky V. (2010). Novel nootropic dipeptide Noopept increases inhibitory synaptic transmission in CA1 pyramidal cells. Neuroscience Letters, 476,, 70-73; http://lipos-c.com/wp-content/uploads/2014/07/Noopept-Reference-31-Novel-nootropic-dipeptide-Noopept-increases-inhibitory-synaptic-transmission-in-CA1-pyramidal-cells.pdf

V. Vakhitova et al. "Molecular Mechanism Underlying the Action of Substituted Pro-Gly Dipeptide Noopept" Acta Naturae. 2016 Jan-Mar; 8(1): 82-89. https://europepmc.org/article/PMC/4837574

Jia X, et al Neuroprotective and nootropic drug noopept rescues α-synuclein amyloid cytotoxicity . J Mol Biol. (2011); https://pubmed.ncbi.nlm.nih.gov/21986202/

http://methylene-blue.myshopify.com/products/noopept-ноопепт-synthetic-substance-99-1000mg

[bromantane]

PRL-8-53, 1000mg of pure substance ≥ 99%.

PRL-8-53 is the absolute top among nootropics! This is a “MUST BE” item in any Stack.

PRL 8-53

Cas No. :51352-87-5

Purity ≥ 99%

Net weight: 1000mg

Molecular Formula: C18H21NO2

Molecular weight: 283.371 g-mol-1

  What is PRL 8-53?

PRL 8-53 (3-[2-[benzylo(metylo)amino]ethyl]methyl benzoate) is a derivative of benzoic acid and phenylmethylamine. Other names for this compound are AC1L22UR, CTK4J4081, LS-36115, 3-(2-(benzylmethylamino)ethyl)benzoate hydrochloride 3-(2-benzylmethylaminoethyl) benzoic acid and ester hydrochloride Methyl 3-(2-(methyl(phenylmethyl)amino)ethyl)methyl ester of benzoic acid. The compound was invented in the 1970s by an American scientist.

The compound affects the dopaminergic and cholinergic systems. It exhibits nootropic effects, that is, it improves cognitive function, enhances concentration and memory. High effectiveness is accompanied by the absence of significant side effects.

Application of PRL 8-53

The product can be used by people, they need to assimilate significant amounts of information, and there is a problem with memorization. Consequently, it helps improve short-term memory and working memory. The latter is responsible for the efficient storage and processing of information and accurate reasoning. In a similar way, m. In. Noopept.

PRL 8-53 can improve cognitive functions cognitive function, as shown in a human study. Volunteers were divided into a nootropic treatment group and a control group. Volunteers were instructed to remember 12 words, and such a memory test was conducted three times: immediately after ingestion of the product, the day after supplementation, and four days after supplementation. The results of the study were very promising - the group that used the tested nootropic preparation even showed a doubling of the score in the memory test.

The nootropic compound has shown beneficial effects in increasing motivation. It fosters the emergence of a desire for action and reduces procrastination, i.e. postponing responsibilities.

Mechanism of action

The product affects the cholinergic system by interacting with receptors for acetylcholine. Therefore, the compound improves the processes of transmission of nerve impulses. In contrast, the product's effect on the dopaminergic system comes down to mimicking the action of dopamine. It binds to receptors for dopamine and stimulates their activity.

PRL 8-53 dosage

Based on the data provided in scientific studies, it is recommended to use the preparation at a dose of 0.05-1.2 mg/ kg body weight. Therefore, the preparation is usually used in a dose of 5 mg per day. Most importantly, it is not a product dedicated to daily, regular use. It is advisable to use the product occasionally, such as 2 to 3 times a week.

To increase the effect of the product on concentration, it is worth taking it together with choline. The combination with phosphatidylserine or Ginkgo biloba intensifies the beneficial effects of PRL 8-53 on memory. On the other hand, combining the product with caffeine allows to effectively increase energy levels.

Other chemical names:

M-(2-(BENZYLMETHYLAMINO)ETHYL)BENZOIC ACID METHYL ESTER

BENZOIC ACID, 3-(2-(METHYL(PHENYLMETHYL)AMINO)ETHYL)-, METHYL ESTER

PRL-8-53 FREE BASE

  References:

Hansl, N.R. A novel spasmolytic and CNS active agent 3-(2-benzylmethylamino ethyl) benzoic acid methyl ester hydrochloride. Experientia 30, 271-272, 1974; https://link.springer.com/article/10.1007/BF01934822

Hansl NR, Mead BT. PRL-8-53: enhanced learning and subsequent retention in humans as a result of low oral doses of new psychotropic agent. Psychopharmacology (Berl), 1978; https://europepmc.org/article/MED/418433

Hansl NR, Hansl AB Learning and Memory Improvement through Chemistry: Dream or Reality in the Offing? Phi Delta Kappan, 1979;

http://methylene-blue.myshopify.com/products/prl-8-53-1000mg-of-pure-substance-99

[bromantane]

L-DOPA ≥ 99%. Pure chemical substance without fillers!

L-DOPA 1000mg of pure Levodopa.

Purity ≥ 99%

Net weight: 1gram

Cas No. :59-92-7

Melting point: 284-286 °C

Density: 1.51g/cm3

Molecular Formula: C9H11NO4

Molecular weight: 197.19

  Other chemical names:

Alanine, 3-(3,4-dihydroxyphenyl)-, L-.

3-Hydroxy-L-tyrosine

(-)-3,4-Dihydroxyphenylalanine

L-Tyrosine, 3-hydroxy-.

L-DOPA is one of the direct precursors of dopamine. The dopamine molecule is the most desirable substance in the human body. It improves well-being increases motivation and allows you to achieve your goals. L-Dopa supplementation increases dopamine levels in the body. Levodopa or L-Dopa is known by various names; Levodopa, Levodopa, L-3. The chemical name of this molecule is 4-dihydroxyphenylalanine. Levodopa is one of the most promising agents for treating neurodegradative diseases including Parkinson's. In a number of scientific articles, we can learn about its high effectiveness in treating CNS disorders. A proven benefit of Levodopa supplementation is increased concentration. Indirectly, L-dopa improves motivation. Other benefits include an increase in sperm motility. The most abundant sources of L-Dopa are the Mucuna Pruriens and Velvet Bean plants. It was from these plants that the L-Dopa molecule was extracted. Most human studies have used single doses of 5,000mg of dried dried product of these plants. A dose of 5grams was given to people suffering from Parkinson's disease. In healthy subjects, the recommended dosage should be started at 2500mg.

Dopa has two isomers:

D-DOPA

L-DOPA

The L-Dopa isomer has a much higher bioavailability. The two compounds differ in the chirality of the molecule. Dried Mucuna Pruriens, exhibits broad nueroprotective and antidegradative effects. It significantly increases the availability of dopamine in the body and restores adequate levels of serotonin.

The offered levodopa has been physicochemically tested by spectroscopy and chromatography. It contains no toxic contaminants or heavy metals. The L-DOPA sold is a synthetic product of very high purity. Due to the high purity of L-Dopa, the product should not be consumed by humans and is only used for laboratory testing.

For more detailed information, see the article on L-Dopa.

Scientific references:

Cordido F, Peino R, Peñalva A, Alvarez CV, Casanueva FF, Dieguez CImpaired growth hormone secretion in obese subjects is partially reversed by acipimox-mediated plasma free fatty acid depressionJ Clin Endocrinol Metab.(1996 Mar).

Angrist B, Gershon SClinical effects of amphetamine and L-DOPA on sexuality and aggressionCompr Psychiatry.(1976 Nov-Dec)Both S, Everaerd W, Laan E, Gooren LEffect of a single dose of levodopa on sexual response in men and womenNeuropsychopharmacology.(2005 Jan)

Bostwick JM, Hecksel KA, Stevens SR, Bower JH, Ahlskog JEFrequency of new-onset pathological compulsive gambling or hypersexuality after drug treatment of idiopathic Parkinson diseaseMayo Clin Proc.(2009 Apr)

Root AW, Russ RDEffect of L-dihydroxyphenylalanine upon serum growth hormone concentrations in children and adolescentsJ Pediatr.(1972 Oct).

Muhlack S, Woitalla D, Welnic J, Twiehaus S, Przuntek H, Müller TChronic levodopa intake increases levodopa plasma bioavailability in patients with Parkinson's diseaseNeurosci Lett.(2004 Jun 17)

Ramya KB, Thaakur SHerbs containing L- Dopa: An updateAnc Sci Life.(2007 Jul).

Vadivel V, Pugalenthi MStudies on the incorporation of velvet bean (Mucuna pruriens var. utilis) as an alternative protein source in poultry feed and its effect on growth performance of broiler chickensTrop Anim Health Prod.(2010 Oct)

http://methylene-blue.myshopify.com/products/l-dopa-99-pure-chemical-substance-without-fillers

[bromantane]

Alpha GPC, purity ≥ 99% weight 1000mg net.

Alpha GPC easily penetrates the BBB (Blood-Brain-Barrier). Consequently, it allows for increased choline availability at synapses. Alpha GPC increases dopamine availability and synergizes neurotransmitter availability at synapses.

Alpha GPC

Purity Alpha GPC≥ 99%

Net weight: 1gram

Cas No. : 28319-77-9

Molecular Formula: C8H20NO6P

Molecular weight: 257.223 g-mol-1

Use: Product for laboratory testing not for consumption.

What is Alpha GPC?

Alpha GPC, or alpha glycerylphosphorylcholine, is one form of choline (along with choline CDP). The compound is also referred to as choline alphoscerate, alpha-glycerophosphocholine, α-GPC, glycerol alphoscerate and (2S)-2,3-dihydroxypropyl-2-(trimethylaspartyl)ethyl phosphate. This form of choline occurs physiologically in the human body. It stands out for its excellent solubility in water. Unlike choline itself,lpha GPC penetrates the blood-brain barrier. And therefore it can be a carrier of choline to the central nervous system - the molecule of this compound contains more than 40% choline. The compound breaks down into choline and glycerophosphate. Both of these compounds are excellent at strengthening cell membranes and ensuring their integrity. In addition, choline is used in the synthesis of the neurotransmitter acetylcholine.

Application of Alpha GPC

Alpha glycylphosphorylcholine is a preparation used to improve cognitive function. It is ideal for people who need to improve their learning processes. The product facilitates the assimilation of information, improves memory. In addition, it supports motivation and willingness to take action.

The product can support the treatment of Alzheimer's disease, a neurodegenerative disorder that progresses with cognitive impairment. Since the product helps increase the synthesis of growth hormone, it can be used in states of growth hormone deficiency. The effects of supplementation can be felt in both short-term and long-term use.

Mechanism of action

Alpha GPC is a carrier of choline, which is used as a precursor for the synthesis of acetylcholine. This neurotransmitter activates the cholinergic system, thus supporting cognitive function. Ingestion of α-GPC is accompanied by increased acetylcholine release in the brain's hippocampus. Enhanced cholinergic neurotransmission was also observed.

The supportive effect of the product on the brain is also due to the improvement of cerebral circulation. By increasing blood pressure in the brain, there is better oxygenation and nourishment of brain cells.

Dosage of Alpha GPC

The daily dose of α-GPC is about 300 to 1,200 mg. Usually 400 mg is taken 2-3 times a day, between jobs. It is beneficial to combine this form of choline with uridine.

References:

https://pubchem.ncbi.nlm.nih.gov/compound/alpha-Glycerylphosphorylcholine

Tamura Y, Takata K, Matsubara K, Kataoka Y. Alpha-Glycerylphosphorylcholine Increases Motivation in Healthy Volunteers: A Single-Blind, Randomized, Placebo-Controlled Human Study. Nutrients. 2021 Jun 18;13(6):2091; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235064/

Parker AG, Byars A, Purpura M, Jäger R. The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility. J Int Soc Sports Nutr. 2015 Sep 21;12(Suppl 1):P41; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595381/

Di Perri R, Coppola G, Ambrosio LA, Grasso A, Puca FM, Rizzo M. A multicentre trial to evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res. 1991 Jul-Aug;19(4):330-41; https://pubmed.ncbi.nlm.nih.gov/1916007/

  Similar chemicals:

28319-77-9

248-962-2

ALPHA-GLYCERYLPHOSPHORYLCHOLINE

CHOLINE ALPHOSCERATE [INN]

CHOLINE ALPHOSCERATE [MI]

ETHANAMINIUM, 2-((((2R)-2,3-DIHYDROXYPROPOXXY)HYDROXYPHOSPHINYL)OXY)-N,N,N-TRIMETHYL-, INNER SALT

CHOLINE ALPHOSCERATE [WHO-DD]

CHOLINE ALPHOSCERATE

CHOLINE ALPHOSCERATE [MART .]

GLIATILIN

CHOLINE HYDROXIDE, (R)-2,3-DIHYDROXYPROPYL HYDROGEN PHOSPHATE, INNER SALT

GLYCEROPHOSPHOCHOLINE [INCI]

GLYCEROPHOSPHOCHOLINE

L-ALPHA-GLYCERYLPHOSPHORYLCHOLINE [USP-RS]

L-.ALPHA.-GLYCERYLPHOSPHORYLCHOLINE

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[bromantane]

Aniracetam ≥ 99%. Pure chemical without fillers 1000mg.

Aniracetam a worthy representative of nootropic drugs belonging to the racetam group.

Aniracetam 1000mg.

Purity ≥ 99%

Net weight: 1 gram

Cas Number: 72432-10-1

Molecular formula: C12H13NO3

Molecular weight: 219,240 g-mol-1

Form: Powder.

Aniracetam is sold under various brand names. The most popular products are:

Draganon

Ampamet

Memodrin

Sarpul

Referan

Aniracetam belongs to a broad group of pharmaceuticals called racetams. Due to the high purity of aniracetam, the product can only be used for laboratory and scientific purposes. You can find detailed information about Aniracetam on our website:

Aniracetam

Are you looking for other molecules? Want to outsource the synthesis of innovative new products? Be sure to contact us we will be happy to help you synthesize new substances!

  http://methylene-blue.myshopify.com/products/aniracetam-99-pure-chemical-without-fillers-1000mg

[bromantane]

Coluracetam, purity of substance ≥ 99%, 1000mg

Coluracetam pure chemical available from the racetam family available for purchase online. Coluracetam’s profile is high affinity for Choline.

Coluracetam 1000 mg

Purity ≥ 99%

Net weight: 1 gram

CAS Number : 135463-81-9

Molecular formula: C19H23N3O3

Molecular weight: 341,411 g-mol-1

Form: Powder

Description from English Wikipedia:

Coluracetam (INN; development code BCI-540; formerly MKC-231) is a putative nootropic agent in the racetam family.[1] It contains a chemical group that is a bioisoster of the 9-amino-tetrahydroacridine family. It was originally developed and tested by Mitsubishi Tanabe Pharma Corporation for Alzheimer's disease. After the drug failed to reach endpoints in its clinical trials, it was licensed by BrainCells Inc for research in major depressive disorder (MDD), which was preceded by a "Qualifying Therapeutic Discovery Program Grant" from the state of California. 2] Results from Phase IIa clinical trials suggest that it would be a potential treatment for comorbid MDD with generalized anxiety disorder (GAD).[3] BrainCells Inc is currently [kiedy?] withdrawing the drug for this purpose.[4] [wymagane pełne cytowanie] It may also have potential use in the prevention and treatment of ischemic retinopathy and retinal and optic nerve damage. [wymagane cytowanie medyczne]

Coluracetam has been shown to reverse the loss of choline acetyltransferase production in the medial septal nucleus of rats exposed to phencyclidine (PCP) and is considered a potential therapeutic drug for schizophrenia.

Coluracetam increases high-affinity choline uptake (HACU), [6] which is the rate-limiting step in acetylcholine (ACh) synthesis. Studies have shown that coluracetam improves learning impairment after a single oral dose to rats exposed to cholinergic neurotoxins. Subsequent studies have shown that it can produce long-term pro-cognitive effects in cholinergic neurotoxin-treated rats by altering the choline transporter regulatory system.[7]Product for laboratory use only. Not for consumption.

Learn more about Coulracetam from the article in Polish:

https://noopept.us/coluracetam-poprawia-prace-mozgu-lagodzi-stany-depresyjne/

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[bromantane]

Oxiracetam / Oxiracetam, purity ≥ 99%, 1000mg

Oxiracetam in Polish Oxiracetam is a substance belonging to the nootropic substances called racetams. Oxiracetam improves cognitive function. Purchase.

Oxiracetam 1000 mg

Purity ≥ 99%

Net weight: 1 gram

Case no: 62613-82-5

Molecular formula: C6H10N2O3

Molecular weight: 158.155 g-mol-1

Form: Powder

Description:

Oxyracetam (substance development code ISF 2522) is a nootropic drug from the racetam family and a very mild stimulant. Several studies suggest that the substance is safe even when large doses are consumed over long periods of time. However, the mechanism of action of the racetam family of drugs is still under investigation. Oxiracetam is not approved by the Food and Drug Administration for any medical use in the United States.

Efforts have been made to explore the possibility of using oxyracetam as a drug to alleviate symptoms of dementia. [6] However, no convincing results have been obtained from studies of patients with Alzheimer's dementia or organic solvent abuse.[6]

Tests conducted on patients with mild to moderate dementia showed beneficial effects as measured by higher scores on tests of logical ability, attention, concentration, memory and spatial orientation. Improvements were also observed in patients with exogenous aftershock syndrome, organic brain syndromes and other dementias.

DBA mice administered oxyracetam showed a significant increase in spatial learning ability, as determined using the Morris water navigation task, compared to the control group. This increase in yield was correlated with an increase in membrane-bound PKC.

Pharmacokinetics Oxyracetam is well absorbed from the gastrointestinal tract with a bioavailability of 56-82%. Maximum serum concentrations are reached within one to three hours after a single oral dose of 800 mg or 2,000 mg, with maximum serum concentrations reaching 19 to 31 μg/ml at these doses.

Oxyracetam is excreted mainly by the kidneys and about 84% is excreted unchanged in the urine. The half-life of oxyracetam in healthy subjects is about 8 hours, while in patients with renal impairment it is 10-68 hours. There is some penetration of the blood-brain barrier, with concentrations in the brain reaching 5.3% of blood concentrations (measured one hour after a single intravenous dose of 2000 mg).

The clearance rates range from 9 to 95 ml/min, and steady-state concentrations after administration of 800 mg twice daily range from 60 μM to 530 μM.

The highest concentrations of oxyracetam in the brain are found in the transparent septum, followed by the hippocampus, cerebral cortex, and lowest in the striatum after an oral dose of 200 mg/kg in rats.[6] Oxyracetam can be quantified in plasma, serum or urine by liquid chromatography using one of several different detection techniques.

The main metabolites of oxyracetam include beta-hydroxy-2-pyrrolidone, N-aminoacetyl-GABOB, GABOB (beta-hydroxy-GABA) and glycine. Phenylpyracetam and all other members of the -racetam family, as well as pyroglutamic acid.

Due to the high purity of the product, it can only be used for laboratory purposes.

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[bromantane]

Bromantan/Ladasten/Bromantane 1000mg, 99% zawartości Bromantanu w opakowaniu!

1000mg Bromantanu.

Czystość produktu przekracza 99% masy netto!

  CAS No .: 87913-26-6

Producent: Nonsensia.

Bromantan zsyntetyzowany w polskim labolatorium.

Forma: Czysty biały krystaliczny puder.

Pakowanie: Saszetka.

Produkt do badań labolatoryjnych nie do spożycia.

Przebadany na obceność metali ciężkich.

  Nazwy handlowe pod którymi dostępny jest Bromantane:

Bromantane

Bromantan

Ladasten

ADK-709

Krótki opis Bromantanu na bazie fachowej literatury naukowej:

Bromantan to psychostymulant który ma paradoksalne działanie. Jednocześnie stymuluje ale ma też działanie antylękowe. Ta unikalna właściwość jest doceniana szczególnie przez profesjonalnych sportowców którzy Bromantane używają jako środek dopingujący. Bromantan został odkryty i zsyntetyzowany przez Moskiewski Instytut Farmaceutyczny. W Rosji Bromantan jest sprzedawany pod handlową marką Ladasten od 2009 roku. Jego unikalne właściwości zostały przetestowane na rosyjskich atletach w których urynie został wykryty jako nieznany wcześniej metabolit. Miało to miejsce podczas letnich igrzysk olimpijskich 1996 roku. Już rok później Międzynarodowa Agencja Antydopingowa zdelegalizowała używanie Bromantanu podczas olimpijskich zmagań. Od 1997 roku aż do teraz Bromantan znajduje się na liście substancji dopingowej WADA (World Anty Doping Agency). Dyskusja rozgożała ze względu na to iż Bromantane mógł a w sposób potwierdzony badaniami klinicznymi podnosić wydolność organizmu. Bromantan jest relatywnie bezpieczny od 50mg do 100mg.  Zarys historyczny Bromantanu to data jego odkrycia w roku 1960 kiedy został odkryty jako pochodna amantadyny. Jeżeli masz skojarzenie z COVID-19 na frazę amantadyna to jest ono jak najbardziej słuszne.

Jeżeli poszukujesz bardziej szczegółowych informacji na temat

Ladastenu / Bromantane lub Bromantanu zapoznaj się z naszymi akrykułami:

https://noopept.us/ladasten-mechanizm-dzialania-zastosowanie-dawkowanie/

https://noopept.us/bromantan-dzialanie-i-dawkowanie/

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[bromantane]

PRL-8-53, 1000mg czystej substancji ≥ 99%.

PRL-8-53 to absolutna czołówka wśród nootropów! Jest to pozycja typu “MUST BE” w każdym Stacku.

PRL 8-53

Cas No. :51352-87-5

Czystość ≥ 99%

Waga netto: 1000mg

Molecular Formula: C18H21NO2

Masa molekularna: 283.371 g·mol−1

  Co to jest PRL 8-53?

PRL 8-53 (3-[2-[benzylo(metylo)amino]etylo]benzoesan metylu) to pochodna kwasu benzoesowego oraz fenylometyloaminy. Inne nazwy tego związku to AC1L22UR, CTK4J4081, LS-36115, chlorowodorek 3-(2-(benzylometyloamino)etylo)benzoesanu 3-(2-benzylometyloaminoetylo) kwasu benzoesowego oraz chlorowodorek estru metylowego 3-(2-(metylo(fenylometylo)amino)etylo)estru metylowego kwasu benzoesowego. Związek został wynaleziony w latach 70-tych XX wieku przez amerykańskiego naukowca.

Związek oddziałuje na układ dopaminergiczny oraz cholinergiczny. Wykazuje działanie nootropowe, czyli poprawia funkcje poznawcze, wzmacnia koncentrację i pamięć. Wysokiej skuteczności działania towarzyszy brak występowania istotnych skutków ubocznych.

Zastosowanie PRL 8-53

Preparat może znaleźć zastosowanie u osób, potrzebują przyswoić znaczne ilości informacji, a pojawia się u nich problem z zapamiętywaniem. W konsekwencji pozwala to na poprawę pamięci krótkotrwałej oraz pamięci roboczej. Ta druga odpowiada za sprawne przechowywanie i przetwarzanie informacji oraz trafne rozumowanie. W podobny sposób działa m. in. Noopept.

PRL 8-53 może poprawiać funkcje poznawcze, co wykazano w badaniu przeprowadzonym na ludziach. Ochotników podzielono na grupę stosującą nootropik oraz grupę kontrolną. Ochotnikom polecono zapamiętać 12 słów, a taki test pamięci przeprowadzono trzykrotnie: bezpośrednio po spożyciu preparatu, dzień po suplementacji oraz cztery dni po suplementacji. Wyniki badania były bardzo obiecujące – w grupie, która zastosowała badany preparat nootropowy wykazano nawet podwojenie wyniku w teście pamięciowym.

Związek nootropowy wykazuje korzystny wpływ na zwiększenie motywacji. Sprzyja pojawieniu się chęci do działania i redukuje zjawisko prokrastynacji, czyli odkładania obowiązków na później.

Mechanizm działania

Preparat oddziałuje na układ cholinergiczny, wchodząc w interakcje z receptorami dla acetylocholiny. Dlatego związek usprawnia procesy przekazywania impulsów nerwowych. Natomiast wpływ preparatu na układ dopaminergiczny sprowadza się do naśladowania działania dopaminy. Łączy się z receptorami dla dopaminy i pobudza ich aktywność.

Dawkowanie PRL 8-53

W oparciu o dane dostarczane w badaniach naukowych, zaleca się stosować preparat w dawce 0,05-1,2 mg/ kg masy ciała. Dlatego zazwyczaj preparat stosowany jest w dawce 5 mg dziennie. Co najważniejsze – nie jest to preparat dedykowany codziennemu, regularnemu stosowaniu. Wskazane jest stosowanie okazyjne preparatu, np. 2 do 3 razy w tygodniu.

W celu zwiększenia wpływu preparatu na koncentrację, warto zażywać go łącznie z choliną. Połączenie z fosfatydyloseryną czy Ginkgo biloba nasila korzystny wpływ PRL 8-53 na pamięć. Natomiast łączenie preparatu z kofeiną pozwala na efektywne zwiększenie poziomu energii.

Inne nazwy chemiczne:

M-(2-(BENZYLMETHYLAMINO)ETHYL)BENZOIC ACID METHYL ESTER

BENZOIC ACID, 3-(2-(METHYL(PHENYLMETHYL)AMINO)ETHYL)-, METHYL ESTER

PRL-8-53 FREE BASE

  Referencje:

Hansl, N.R. A novel spasmolytic and CNS active agent 3-(2-benzylmethylamino ethyl) benzoic acid methyl ester hydrochloride. Experientia 30, 271–272, 1974; https://link.springer.com/article/10.1007/BF01934822

Hansl NR, Mead BT. PRL-8-53: enhanced learning and subsequent retention in humans as a result of low oral doses of new psychotropic agent. Psychopharmacology (Berl), 1978; https://europepmc.org/article/MED/418433

Hansl NR, Hansl AB Learning and Memory Improvement through Chemistry: Dream or Reality in the Offing? Phi Delta Kappan, 1979;

http://methylene-blue.myshopify.com/products/prl-8-53-1000mg-czystej-substancji-99

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