#l-dopa

[eosphoroz]

"But if you want a name, let me call it the gateway between life and death. I'll bring you with me through this gateway. And why? Because I am a coward. And I love you too much to let you go."

[oftachancer]

I was today years old when I learned about encephalitis lethargica and the use of l-dopa to wake people from the “sleeping sickness”… and all the various ways that people responded to those treatments… like people losing control of their bodies and emotions… and all I can think is… Pharamond?

[thehumanfront]

The Human Front > Live!

New post > Film

#thehumanfront is back! Please have a look at the excellent new website: it’s easy to navigate, it’s polished, and it has brand new sections.

The new look symbolises a transition in content. The themes are now philosophy, philosophy, and philosophy, while articles are snappier than before as authors continue to delve into many real-life problems. Original articles have been refined to boot.

To herald the direction the latest article, featured in the image above, is an existential review of the film Awakenings (1990), which stars Robin Williams and Robert De Niro. Awakenings is a touching story of hope. Catatonic patients enter a trial to treat encephalitis lethargica. Will it be successful? What happens if it isn’t?

Dr Sayer: ‘You told him I was a kind man. How kind is it to give life, only to take it away?’

Eleanor: ‘It's given to and taken away from all of us.’

Dr Sayer: ‘Why does that not comfort me?’

We continue to welcome and edit content from creators. Please see the website for further details.

[neurosingularity]

What is Dopamine? A Deep Exploration of the Dopaminergic Systems and its Enhancement

Dopamine is one of the main neurotransmitters in the brain. It is most commonly recognized for its role in reward, motivation, and pleasure, but also plays a crucial part in modulating focus, motivation, cognitive flexibility, and emotional resilience. In addition to these creative-productive capacities and states, dopamine is one of the main regulators of motor control and coordination of body movements.

[lepromatosis]

From the book Awakenings by Oliver Sacks. Sacks worked with Encephalitis lethargica patients living at the Mt. Carmel chronic hospital where they had been living for decades, largely forgotten about by the outside world.

Intrigued but the bizarre nature of their condition and its mysterious origin, he became convinced these people were not beyond reach. Sacks treated them with high doses of an experimental Parkinson’s drug called L-DOPA. Amazingly, the patients responded by “awakening” from their lost states. They seemed fully aware and seemingly cured.

Unfortunately, the initial positive reactions were marred by increasingly serious side effects. Once the medicine was stopped, as many chose to do, those treated quickly fell back into their statuesque slumber. Not all would make such a choice, however, as was the case with Hester (shown above). 

[zenobiavita]

The fact that you have to balance between "Mad but Mobile" and "Stiff but Sane" in Parkinson's Disease is crazy.

[medicomunicare]

Individuando cause genetiche del parkinsonismo giovanile: le mutazioni a carico del gene ADORA1

Individuando cause genetiche del parkinsonismo giovanile: le mutazioni a carico del gene ADORA1

La malattia di Parkinson colpisce il 3% della popolazione di età superiore ai 65 anni e l’età media di insorgenza è di 60 anni. La malattia di Parkinson ad esordio precoce (EOPD), che rappresenta il 5-10% di tutti i casi di malattia di Parkinson, è definita come l’insorgenza del parkinsonismo prima dell’età 40 (occasionalmente 50). Sebbene di solito sia idiopatico, si ritiene che fino al 5-10%…

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[bromantane]

L-DOPA ≥ 99%. Pure chemical substance without fillers!

L-DOPA 1000mg of pure Levodopa.

Purity ≥ 99%

Net weight: 1gram

Cas No. :59-92-7

Melting point: 284-286 °C

Density: 1.51g/cm3

Molecular Formula: C9H11NO4

Molecular weight: 197.19

  Other chemical names:

Alanine, 3-(3,4-dihydroxyphenyl)-, L-.

3-Hydroxy-L-tyrosine

(-)-3,4-Dihydroxyphenylalanine

L-Tyrosine, 3-hydroxy-.

L-DOPA is one of the direct precursors of dopamine. The dopamine molecule is the most desirable substance in the human body. It improves well-being increases motivation and allows you to achieve your goals. L-Dopa supplementation increases dopamine levels in the body. Levodopa or L-Dopa is known by various names; Levodopa, Levodopa, L-3. The chemical name of this molecule is 4-dihydroxyphenylalanine. Levodopa is one of the most promising agents for treating neurodegradative diseases including Parkinson's. In a number of scientific articles, we can learn about its high effectiveness in treating CNS disorders. A proven benefit of Levodopa supplementation is increased concentration. Indirectly, L-dopa improves motivation. Other benefits include an increase in sperm motility. The most abundant sources of L-Dopa are the Mucuna Pruriens and Velvet Bean plants. It was from these plants that the L-Dopa molecule was extracted. Most human studies have used single doses of 5,000mg of dried dried product of these plants. A dose of 5grams was given to people suffering from Parkinson's disease. In healthy subjects, the recommended dosage should be started at 2500mg.

Dopa has two isomers:

D-DOPA

L-DOPA

The L-Dopa isomer has a much higher bioavailability. The two compounds differ in the chirality of the molecule. Dried Mucuna Pruriens, exhibits broad nueroprotective and antidegradative effects. It significantly increases the availability of dopamine in the body and restores adequate levels of serotonin.

The offered levodopa has been physicochemically tested by spectroscopy and chromatography. It contains no toxic contaminants or heavy metals. The L-DOPA sold is a synthetic product of very high purity. Due to the high purity of L-Dopa, the product should not be consumed by humans and is only used for laboratory testing.

For more detailed information, see the article on L-Dopa.

Scientific references:

Cordido F, Peino R, Peñalva A, Alvarez CV, Casanueva FF, Dieguez CImpaired growth hormone secretion in obese subjects is partially reversed by acipimox-mediated plasma free fatty acid depressionJ Clin Endocrinol Metab.(1996 Mar).

Angrist B, Gershon SClinical effects of amphetamine and L-DOPA on sexuality and aggressionCompr Psychiatry.(1976 Nov-Dec)Both S, Everaerd W, Laan E, Gooren LEffect of a single dose of levodopa on sexual response in men and womenNeuropsychopharmacology.(2005 Jan)

Bostwick JM, Hecksel KA, Stevens SR, Bower JH, Ahlskog JEFrequency of new-onset pathological compulsive gambling or hypersexuality after drug treatment of idiopathic Parkinson diseaseMayo Clin Proc.(2009 Apr)

Root AW, Russ RDEffect of L-dihydroxyphenylalanine upon serum growth hormone concentrations in children and adolescentsJ Pediatr.(1972 Oct).

Muhlack S, Woitalla D, Welnic J, Twiehaus S, Przuntek H, Müller TChronic levodopa intake increases levodopa plasma bioavailability in patients with Parkinson's diseaseNeurosci Lett.(2004 Jun 17)

Ramya KB, Thaakur SHerbs containing L- Dopa: An updateAnc Sci Life.(2007 Jul).

Vadivel V, Pugalenthi MStudies on the incorporation of velvet bean (Mucuna pruriens var. utilis) as an alternative protein source in poultry feed and its effect on growth performance of broiler chickensTrop Anim Health Prod.(2010 Oct)

http://methylene-blue.myshopify.com/products/l-dopa-99-pure-chemical-substance-without-fillers