🦊

ita skramz gang | 20something | fagdyke

[oktjabr]

they're is a beautiful butch sat in front of me on the #train .aaaand post

[goryhorroor]

130 favorite horror movies: (18/130)

"repent, the end Is extremely fucking nigh"

-28 days later (2002) dir. danny boyle

[angelbabymikaa]

“potentially mature content” yeah that’s my pervert friend i hope it’s mature content that’s what i followed them for

[candleisblue]

4 years ago today I was seeing MCR for the first time in my life and now I'm starting hrt

[killrockstar]

#Thursday

[iero]

Some of you have never been on a bender and it shows. 

[desmondsprettyface]

So? Why don’t you blow me?

[chameliyun]

just tried to reference the xkcd "today's lucky 10,000" comic but I wanted to explain xkcd first, so I was like "you probably know the one about experts in the field overestimating their audience's familiarity with the subject matter" and uh. he didn't. love me some irony

[killrockstar]

24hr revenge therapy used to be my fave but i got old and i like Dear you more now

[candleisblue]

About transdermal/cutaneous drugs (creams/gels...):

Diffusion to depths happens in a cone-shaped manner, to achieve higher subcutaneous absorption is necessary to apply the drug on a large surface. Cutaneous absorption varies on the body zone:

- higher in: scalp, forehead, mandible, armpit and scrotum (especially this one). Generally it's higher in places highly vascularized and with thin skin

-lower in: palm, plantar arch and ankles. Generally it's lower in poorly vascularized areas and thick stratum corneum

The famous study on hydrocortisone absorption reported skin permeability was: 0.1 for sole and 42 for scrotum (lowest and highest values).

For estradiol:

Transdermal and intramuscular have the highest half-lives (time it takes to reach half of the drug concentration). Transdermal has low bioavailability (for example if you use 100g of product the bioavailability is the fraction of product that reach systemic circulation out of 100g) but its very potent. Also it bypasses the first pass effect (hepatic metabolism). Intramuscular has almost 100% bioavailability, acts fast and has fast duration.

For testosterone:

Transdermal gel has low bioavailability, most permeable areas are thighs/abdomen (hair WILL grow more in the application area). IM injections have a LONG duration and bioavailability is almost 100%.

Oral route is always the worse way to take hrt because of high first pass effect :')

I still have to take my pharmacology exam but I've been studying for it for MONTHS. Anyways, I'm not an expert and these are general information, for more details read about your specific drug :)

E niente spero che non mi bannano il profilo per aver osato essere troppo trans su tumblr

[candleisblue]

I'm just now watching WWE clash in Italy and its craaaazy this is the first time i enjoy man wrestling

[candleisblue]

Sol ruca my beloved <3

[dykeselfcest]

nostalgia is always a liar except for when the cool boomers are like "I miss the 70s because it was after the birth control pill became available but before the aids crisis so you could just fuck raw all the time." they're just correct

[latinotiktok]

[escarabangel]

Translation: "Chancho! I'm leaving now dude, i'm leaving to go work now dude."

"If someone breaks in dude, you beat the ever-loving shit out of them real hard dude, you beat the shit out of them, Chancho, you hear me?"

"You just beat the shit out of anyone who breaks in!"

translation notes:

The dogs name is 'Chancho', a slang word for a pig. Basically, its like the dog is named 'piglet' 🥺

[aspec-woomy]

I fucking can't with his little face

[bepeu-deactivated20171202]

the human body is amazing u can just not sleep for 48 hours straight and all that happens is that you go crazy and are dying

[candleisblue]

I've been to places but apparently I've never been to places (I'm currently in a taz) (I've been to taz before) (but this one...) (my worse nightmares couldn't prepare me for this)

[candleisblue]

Fuori di casa alle 2 di pomeriggio, stazione piena di persone che non identificherò per non sembrare razzista, caldo torrido...la scena mi ha portato a fare cose che non farei nemmeno con una pistola puntata contro

[nyancrimew]

if english speakers can learn just one more german word to use it should be "ticketficker" ("ticketfucker", derogatory slang term 4 "ticket inspector")