Quiddity @dreamyclouds69 - Tumblr Blog

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Why Does Meth Make You so F*cking Horny?

Ephedra's (the plant) ephedrine, similar to methamphetamine's base, ramps up dopamine and norepinephrine, sparking energy and arousal that can juice libido. In old Chinese medicine, ma huang was an aphrodisiac for that buzz. Meth cranks it higher, flooding the brain for wild, urgent sex drive—think supercharged sensitivity and stamina. But it flips: crashes mean exhaustion and limp results.

Studies on ephedra are thin, but rats show ephedrine boosts erections via nitric oxide, echoing meth's blood flow tricks. No solid human trials, though; ephedra got yanked in two thousand four because it was the most popular meth precursor at the time, and Sen. Chuck Grassley wanted to get on TV a lot more for a few weeks, I guess. Whispers on forums mix ephedra brews for meth-lite kicks minus the draconian drug laws. But this is all conjecture based on anecdotal evidence, but about 5,000-6,000 years of anecdotal evidence.

#meth #methsex

hey... Im new to tumblr and Ive heard its got an interesting collection of like minded people on here.... What state are you located in

See the PM I sent you. Thx

jollycloudgiant

ultrafacts

dreamyclouds69

Jules Verne's novel "Around the World in Eighty Days" was first published in 1872. The novel tells the story of Phileas Fogg, a London gentleman who bets that he can travel around the world in 80 days or less. He is accompanied by his French valet, Passepartout, and faces many challenges and adventures along the way.

Nellie Bly, an American journalist, completed the journey in 72 days in 1889-1890, 17-18 years after it was published. She was challenged by her newspaper, The World, to beat the fictional record of Phileas Fogg, the protagonist of Verne's novel. She even met Verne in Amiens during her trip. Who knows how many other people may have achieved a similar feat. That's not the point of the book.

Verne was a visionary author who anticipated many scientific and technological developments in his novels, such as submarines, airplanes, rockets, satellites, and videoconferencing. He also explored themes such as environmentalism, social justice, human rights, and international cooperation. He is widely regarded as one of the founders of science fiction and one of the most influential writers of all time.

#realfacts

itsyiffmas

Three Important Rules For Being A Drug Addict

1. Function 2. Maintain 3. Know limits

dreamyclouds69

Why is everyone who ever takes an illegal drug a "Drug Addict?" If a person can 1.) Function, 2.) Maintain, and 3.) Know [their] limits, THEY OBVIOUSLY AREN'T A DRUG ADDICT! They may be drug users but not problematic drug users. Nonmedical, unscientific bureaucrats, along with media motivated by the profits of sensationalized drug horror stories, have determined which drugs are "dangerous" and therefore illegal.

Meth, for example, was never the most addictive drug ever, as claimed by many. Only 9-16% of people who ever use meth become problem users. The vast majority of heroin users don't use it again. Most drug use is a phase that people grow out of or through. Some may take longer than others and there are some negative effects for some people and families. However, the current treatment modalities are counterproductive because they block any possibility from scientific research, and not just propaganda made up by unscientific law enforcement.

neurosciencestuff

Ketamine acts fast to treat depression and its effects last — but how?

In contrast to most antidepressant medications, which can take several weeks to reduce depressive symptoms, ketamine — a commonly used veterinary anesthetic — can lift a person out of a deep depression within minutes of its administration, and its effects can last several weeks. Researchers have long-wondered how ketamine can both act quickly and be so long-lasting.

Now, researchers led by Mark Rasenick, distinguished professor of physiology and psychiatry in the University of Illinois at Chicago College of Medicine, describe the molecular mechanisms behind ketamine’s ability to squash depression and keep it at bay. They report their findings in the journal Molecular Psychiatry.

Two-thirds of participants in clinical studies who did not respond to traditional antidepressants experienced fast and lasting resolution of their depressive symptoms after being given ketamine intravenously, Rasenick explained. The effects of ketamine typically lasted about a week — much longer than would be expected with ketamine’s six-hour half-life in the body.

Rasenick and his colleagues used a cellular model system to investigate how ketamine acted.

In previous research, Rasenick and his colleagues showed that SSRIs — the most commonly prescribed class of antidepressants, which includes Prozac and Zoloft — work in the brain by moving molecules called G proteins off of “lipid rafts” on the cell membrane, where the G proteins are held inactive. G proteins produce cyclic AMP, which nerve cells need to signal properly. People with depression, Rasenick found, tend to have a greater proportion of their G proteins packed into these membrane patches, along with dampened brain cell signaling, which may contribute to symptoms of depression, including a feeling of overall numbness.

In the earlier research, when Rasenick exposed rat brain cells to SSRIs, the drug accumulated in the lipid rafts, and G proteins moved out of the rafts. The movement was gradual, over the span of several days, which Rasenick thinks is the reason why SSRIs and most other antidepressants can take a long time to begin working.

In his current research, Rasenick and his colleagues performed a similar experiment with ketamine and noticed that the G proteins left the rafts much faster. G proteins began migrating out of the lipid rafts within 15 minutes. And the long-lasting effects of ketamine may be due to the fact that the G proteins were very slow to move back into the lipid rafts, Rasenick explained.

The finding contradicts the long-held idea that ketamine works solely by blocking a cellular receptor called the NMDA receptor, which sits on the surface of nerve cells and helps transmit signals.

In fact, when the researchers knocked out the NMDA receptor, ketamine still had the same effect on the cells — quickly moving G proteins out of lipid rafts on the cell membrane.

“When G proteins move out of the lipid rafts, it allows for better communication among brain cells, which is known to help alleviate some of the symptoms of depression,” Rasenick said. “Whether they are moved out by traditional antidepressants or ketamine, it doesn’t matter, although with ketamine, the G proteins are very slow to move back into the lipid rafts, which would explain the drugs long-term effects on depressive symptoms.”

“This further illustrates that the movement of G proteins out of lipid rafts is a true biomarker of the efficacy of antidepressants, regardless of how they work,” Rasenick explained. “It confirms that our cell model is a useful tool for showing the effect of potential new antidepressant drug candidates on the movement of G proteins and the possible efficacy of these drugs in treating depression.”

dreamyclouds69

I am willing to bet anything that someone at DEA or FDA got fired because of this. This isn't Special K, the club drug Ketamine, really. It's a little different and the doses are diferent. Also, don't believe anyone who says there's an online pharmacy who has Ketamine. They can't in the United States.

I think this study shows how little is really known about depression as much as anything. That, and what a colossally corrupt, multi trillion dollar swindle SSRI's truly are.

dreamyclouds69

DEA Agent Using War on Drugs Tax Dollars

marginalutilite

“When journalists report about heroin, their efforts almost inevitably suffer from the same problem. For short, we’ll call it the Halsted Omission. “William Halsted was one of the founders of Johns Hopkins Hospital. He’s often credited as the inventor of modern surgery for his pioneering use of anesthesia and sterilized operating rooms. During his distinguished 45-year career, he was among the first American surgeons to perform a blood transfusion, remove a gall bladder or do a mastectomy. He was also, for more than three decades, addicted to morphine, a close chemical cousin of heroin, which impaired his professional and personal lives so little that only his closest associates knew about it. "If you didn’t think such a thing was possible, it’s not your fault. If there’s a form of journalism that suffers from endemic selection bias, it’s drug stories. Heroin users who manage to adapt their lives to their addictions, or vice versa, never get mentioned in news accounts or documentaries. Neither do those who try heroin, don’t like it, and quit immediately; or those who chip occasionally without falling into real addiction. In the stylebook of drug journalism, "heroin user” means “dead or dysfunctional.” Those exist, of course, but they are not the whole story.“”

— Glenn Garvin in “Heroin for the Holidays” at Reason

dreamyclouds69

Heroin, Reefer, Crack, Meth, they've all been the object of hatred by many who probably have good reasons, but they've been loathed and despised by many more people who have no idea why, who've never used them or even known that anyone they knew or met used them. They are targets of the most effective propaganda campaigns in history, yet they cut off their noses to spite their own faces. Every time the lies are exposed, they have to create another more dangerous villain to invent harsher, more dangerous and deadly lies, so eventually one of them will become truth.

thehopefulquotes

“Every year on your birthday, you get a chance to start new.”

— Sammy Hagar

dreamyclouds69

This is one of the dumbest things I've seen in years so maybe Sammy Hagar did say it. It makes absolutely no sense to a normal, adult person, who's drunk less than 3 liters of Cabo Wabo, so perhaps Sammy was in such a state when he composed this muddled pile of word salad that someone now considers "quotable."