Without giving too much away, there’s an NPC you must meet in their office who offers you a chair to sit down; refusing to sit in the chair requires passing a Volition skill check. If you do sit down, the chair proves to be so incredibly uncomfortable that you have to make a Pain Threshold saving throw or suffer a single point of damage.
It’s completely possible – albeit very unlikely – to put yourself in a position where your Volition is too low to refuse to sit down, your Pain Threshold is too low to avoid taking damage from doing so, you have only a single point of Health remaining, and you’ve exhausted every single source of healing that’s accessible to you at that point.
If all of those factors line up, you cannot proceed because you lack the confidence to refuse to sit in a chair that’s so uncomfortable it kills you.