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@prostatecancernewstoday
20 Things Men with Prostate Cancer Wish Healthy Friends, Family Knew
I was diagnosed with prostate cancer when I was 57. My PSA (prostate-specific antigen) remains undetectable seven years after my surgery.
I expected there’d come a time when I’d give up my cancer survivor status. I thought I’d return to thinking about myself in the same way I thought about myself prior to my diagnosis. That never happened, and I don’t believe it ever will. In other words, once a…
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Researchers Identify Potential Therapeutic Target for Advanced Prostate Cancer
Researchers in Spain studying the 3D structure of the androgen receptor have identified a key protein for its activation called TFIIF, making it a possible therapeutic target for advanced prostate cancer.
The study, “Regulation of Androgen Receptor Activity by Transient Interactions of Its Transactivation Domain with General Transcription Regulators,” was published in the journal Structure.
The…
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PET Scans Help Identify Certain PC Patients Who May Benefit from Salvage Radiation Therapy
A recent study-based article demonstrates that prostate-specific membrane antigen (PSMA)-PET scans can identify prostate cancer patients likely to benefit from salvage radiation therapy (SRT) after a radical prostatectomy, and that the scans are more informative than traditional clinical parameters.
PSMA is a well-characterized imaging biomarker of prostate cancer. It can be used as a radio…
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Rutgers Researcher Awarded $954,000 for Work on Prostate Cancer Hormone Therapy Xtandi
The chief of urologic oncology at Rutgers Cancer Institute of New Jersey, Isaac Yi Kim, MD, PhD, MBA, has been awarded a $954,000 Prostate Cancer Research Program Idea Development Award for Established Investigators to support work on a hormone therapy, Xtandi (enzalutamide), which targets a protein that prostate cancer cells need for growth and survival.
The grant was awarded by the U.S.…
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Researchers Link Aggressiveness of Prostate Cancer to Process of RB Gene Loss
Researchers found that the mechanism by which a tumor loses a key tumor suppressor, the retinoblastoma or RB gene, influences the aggressiveness of prostate cancer.
The study, “Differential impact of RB status on E2F1 reprogramming in human cancer,” was published in The Journal of Clinical Investigation.
The retinoblastoma (RB) susceptibility gene was one of the first genes identified as a tumor…
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7 Things to Do When the Misery of Cancer Won't End
7 Things to Do When the Misery of Cancer Won’t End
When background music is playing softly, it’s possible to forget the music is continually playing. When it’s blaring, the music never fades into the background, and it’s intrusive all the time.
You have a serious problem when your cancer-related symptoms are like blaring background music. Your pain or quality-of-life issues make life miserable every minute of every day.
Here’s a partial list of…
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Shorter but Higher-dose Radiation Course Cuts Risk of Prostate Cancer Returning, Study Finds
Delivering radiation in a shorter time frame significantly reduced the chance of prostate cancer returning in men with an intermediate-risk form of the disease, a study found.
The approach failed to improve survival, however. Researchers argued that a survival benefit may occur only in a subset of patients in excellent health. They called for more research on the topic.
The study, “Conventional…
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Safety Concerns Make Bayer Unblind Prostate Cancer Trial of Xofigo Combination
An Independent Data Monitoring Committee has asked Bayer to unblind a Phase 3 clinical trial of a Xofigo (radium-223)-based therapy for prostate cancer after data indicated more bone fractures in study participants.
The study randomly assigned prostate cancerpatients to treatment with Xofigo or a placebo — both given in combination with Zytiga (abiraterone acetate) and prednisone or prednisolone.…
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ZERO and Perthera Launch ‘Decode Your Prostate Cancer’ Program
In collaboration with Perthera, a precision medicine intelligence company, the nonprofit group ZERO is launching “Decode Your Prostate Cancer,” a program to give men fighting prostate cancer (PC) the ability to create personalized treatment plans.
Each prostate cancer diagnosis is different due to its genetic form, and personalized medicine has been shown to offer an effective approach to…
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Researchers to Examine Link Between Battlefield Chemical Exposure and Prostate Cancer
Researchers at Baylor College of Medicine will study the link between exposure to battlefield chemicals and prostate cancer (PC) in U.S. veterans with a $1 million Challenge Award from the Prostate Cancer Foundation.
The goal is to better understand specific mutations or changes in expression that might have occurred as a result of exposure to toxic materials on the battlefield.
Researchers will…
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Prostate Cancer Often Deadly for Urban American Indians and Alaskan Natives, Study Shows
The mortality toll of prostate and breast cancer is significantly higher in urban American Indian and Alaskan native populations compared to non-Hispanic whites, a retrospective study shows.
The study, “Disparities in Prostate, Lung, Breast, and Colorectal Cancer Survival and Comorbidity Status among Urban American Indians and Alaskan Natives,” appeared in the journal Cancer Research.
“It’s been…
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Don't Let Cancer Steal Your Holiday Joy
Don’t Let Cancer Steal Your Holiday Joy
There’s a group of men struggling with advanced prostate cancer who know, for certain, this is their last celebration of the holidays on this side of heaven.
Folks who are healthy don’t think this way. They assume they have many more holiday seasons in their future.
The fact is, there is a significantly larger number of healthy folks who won’t be alive next year for the holidays than there are…
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Study Furthers Understanding of Low Testosterone Levels in Prostate Cancer Risk
Men with very low testosterone levels are less likely to develop prostate cancer, but if they do, chances are they will develop an aggressive form of the disease, according to researchers at the University of Oxford.
The findings were presented in November during the 2017 National Cancer Research Institute (NCRI) Conference, in Liverpool, U.K. The poster presentation was titled, “Low circulating…
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UVA Researchers Developing Tool to Help Prostate Cancer Patients Make Complex Treatment Decisions
University of Virginia (UVA) Cancer Center researchers are developing a new tool to help prostate cancer (PC) patients weigh the potential risks and benefits of their treatment options.
The app’s engineering was kicked off after UVA researchers invited 22 experts in the field to provide feedback on their approach and identify the most urgent needs in the process.
The group included prostate…
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Genomic Health and Cleveland Diagnostics Partner to Develop New Prostate Cancer Tests
Genomic Health and Cleveland Diagnostics have entered into a global licensing agreement to develop and commercialize new prostate cancer tests based on the latter company’s IsoPSA technology.
The goal is to develop a high-prostate-specific antigen (PSA) reflex test to accurately predict the presence of high-grade cancer — as measured by a Gleason score of 7 or above — before patients are…
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Researchers Uncover Key Molecular Process that Leads to Prostate Cancer Metastasis
Researchers have identified a key protein, called Snail1, that appears to be crucial to the spread of prostate cancer cells, a new study shows. The finding could lead to new therapies to block these metastatic cells.
Metastasis refers to the process in which cancer cells travel from the site of a tumor to secondary locations where additional tumors form. Once this happens, a patient’s prognosis…
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Prostate Health Index Test Reduces Unnecessary Biopsies in Men Suspected of Cancer, Study Shows
Using the Prostate Health Index test to help diagnose prostate cancer significantly reduces unnecessary and expensive biopsies, a study reports.
Beckman Coulter came up with the tool for patients whose digital rectal exam yields nothing suspicious but who have high levels of PSA. Elevated levels of that protein are the main biomarker of the disease.
U.S. regulators approved the index as a…
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