Cytokines & Receptors P1. of 5
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Cytokines & Receptors P1. of 5
Quick Sheet: Hormones Produced in the endocrine system
Gland
Hormone(s) Produced
Primary Function(s)
Hypothalamus
Regulatory hormones
Control release of hormones from anterior pituitary
Hypothalamus (released from posterior pituitary)
Antidiuretic hormone (ADH)
Stimulates both the kidneys to decrease urine output and thirst center to increase fluid intake when the body is dehydrated; in high doses, ADH is a vasoconstrictor (thus, it is also called vasopressin)
Oxytocin
Contraction of smooth muscle of uterus; ejection of milk; increases feelings of emotional bonding between individuals
Pituitary gland (anterior)
Thyroid-stimulating hormone
Stimulates thyroid gland to release thyroid hormone
Prolactin (PRL)
Regulates mammary gland growth and breast milk production in females; may increase secretion of testosterone in males
Follicle-stimulating hormone (FSH)
Controls development of both oocyte and ovarian follicle (spherical structure that houses an oocyte) within ovaries; controls development of sperm within testes
Luteinizing hormone (LH)
Induces ovulation of secondary oocyte from the ovarian follicle
Controls testosterone synthesis within testes
Adrenocorticotropic hormone (ACTH)
Stimulates adrenal cortex to release corticosteroids (e.g., cortisol)
Growth hormone (GH)
Release of insulin-like growth factors (IGFs) from liver; GH and IGFs function synergistically to induce growth
Pineal gland
Melatonin
Helps regulate the bodyās circadian rhythms (biological clock); functions in sexual maturation
Thyroid gland
Thyroid hormones:
T3 (triiodothyronine) and
T4 (tetraiodothyronine or thyroxine)
Increase metabolic rate of all cells; increase heat production (calorigenic effect)
Calcitonin
Decreases blood calcium levels; most significant in children
Parathyroid glands
Parathyroid hormone (PTH)
Increases blood calcium levels by stimulating both release of calcium from bone tissue and decrease loss of calcium in urine; causes formation of calcitriol hormone (a hormone that increases calcium absorption from small intestine)
Thymus
Thymosin, thymulin, thymopoietin
Maturation of T-lymphocytes (a type of white blood cell or leukocyte)
Adrenal cortex
Mineralocorticoids (e.g., aldosterone)
Regulate blood Na+ and K+ levels by decreasing the Na+ and increasing the K+ excreted in urine
Glucocorticoids (e.g., cortisol)
Participate in the stress response; increase nutrients (e.g., glucose) that are available in the blood
Gonadocorticoids (e.g., dehydroepiandrosterone [DHEA])
Stimulate maturation and functioning of reproductive system
Adrenal medulla
Epinephrine (EPI) and norepinephrine (NE)
Prolong effects of the sympathetic division of the autonomic nervous system
Pancreas
Insulin
Decreases blood glucose levels
Glucagon
Increases blood glucose levels
Testes (gonads)
Testosterone
Stimulates maturation and function of male reproductive system
Inhibin
Inhibits release of follicle-stimulating hormone (FSH) from anterior pituitary
Ovaries (gonads)
Estrogen and progesterone
Stimulates maturation and function of female reproductive system
Inhibin
Inhibits release of follicle-stimulating hormone (FSH) from anterior pituitary
Heart
Atrial natriuretic peptide (ANP)
Functions primarily to decrease blood pressure by stimulating both the kidneys to increase urine output and the blood vessels to dilate
Kidneys
Erythropoietin (EPO)
Increases production of red blood cells (erythrocytes)
Liver
Angiotensinogen
Converted by enzymes released from the kidney and within the inner lining of blood vessels to angiotensin II; increases blood pressure by causing vasoconstriction and decreasing urine output; stimulates thirst center
Insulin-like growth factors (IGFs)
Functions synergistically with growth hormone to regulate growth
Erythropoietin (EPO)
Increases production of red blood cells (erythrocytes); note that kidneys are the major producers of EPO
Stomach
Gastrin
Facilitates digestion within stomach
Small intestine
Secretin
Regulates digestion within small intestine by helping to maintain normal pH within small intestine
Cholecystokinin (CCK)
Regulates digestion within small intestine by facilitating digestion of nutrients within small intestine
Skin
Vitamin D3
Converted by enzymes of liver and kidney to calcitriol; functions synergistically with PTH and increases calcium absorption from small intestine
Adipose connective tissue
Leptin
Helps regulate food intake
Placenta
Estrogen and progesterone
Stimulates development of fetus; stimulates physical changes within mother associated with pregnancy including those in the uterus and mammary glands
Thyroid function tests
Standard Tests
TSH levels
Free T4 (fT4) levels
Measurements of total T4 + T3 used to be common however detects both bound and free T3 + T4
Elevated total T4 may occur in healthy individuals if there is an increase in binding protein concentrations
Reliable tests now exist for free T4 + T3
T3 = 3.9-6.7 pmol/L
T4 = 12-22 pmol/L
Thyroid-stimulating hormone
Produced by the pituitary gland, not the thyroid, however:
TSH levels are controlled by negative feedback ā can be indication of thyroid function (changes in T3+T4 will result in changes in TSH to try compesate)
TSH levels greatly elevated in hypothyroidism ā >10 fold increase over reference values
More sensitive marker than decreased fT4 - increased TSH occurs before fT4 decreases
TSH levels greatly supressed in hyperthyroidism
Low concentrations can also occur in non-thyroidal illness
TSH measurement is the first-line test of thyroid function.
Free T4 + T3 Measurements
Desirable as free hormone is clinically relevant
Total levels can change under conditions that alter thyroxine-binding globulinĀ (TBG) levels e.g. pregnancy
Large changes in TBG may still affect fT4 + fT3 levels
fT3 levels often normal in hypothyroidism
fT3 levels usually raised more than fT4 levels in hyperthyroidism
Unless complicated by an illness effecting conversion of T4 to T3
Therefore: ā fT4 levels are a better indication of hypothyroidism
fT3 levels are a better indication of hyperthyroidism
Endocrine Signalling - Watercolours can be found on Jennyspapercraftco etsy shop
Pancreas and Metabolism - Leaf and circle headers from Jennyspapercraftco on Etsy
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