#amyloid

[didanawisgi]

Recipe for disaster: A dash of spike, a pinch of nurpy brain cells makes for an amyloid-β omelette that you're sure to forget about!

Because of neurodegeneration... Too early?

[bpod-bpod]

Seeking the Source

One of the key biological hallmarks of Alzheimer’s disease is the presence of clumps of amyloid molecules in the brain, known as plaques. For many years, researchers have focused on figuring out why amyloid plaques form and how to get rid of them, yet these efforts haven’t led to effective treatments for what is currently an incurable condition. One issue is that amyloid is not only made in the brain but elsewhere in the body too, so it has been hard to figure out where it’s coming from. Researchers have recently managed to disentangle the two sources by using genetically engineered mice that make mouse amyloid in the brain and human amyloid in the liver. The human liver amyloid could still get into the brain (highlighted in red in these brains scans), triggering changes typically seen in Alzheimer’s disease and challenging our understanding of how the disease starts and progresses.

Written by Kat Arney

Image from work by Virginie Lam, Ryusuke Takechi and John C. L. Mamo, and colleagues

Curtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Bentley, WA, Australia

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in PLOS Biology, September 2021

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[neurosciencenews]

The functioning amyloid in a healthy brain

The FXR1 protein in the brains of healthy, young rats functions in an amyloid form. The protein has previously been linked to controlling long-term memory formation and emotion.

[intelligentliving]

Dementia Vaccine To Enter Human Trials Following Successful Tests On Mice

The vaccine treatment is a combination of two drugs that targets and removes brain plaque and tau protein aggregate linked to dementia.

[medicalmeister]

[healthinnovations]

Astrocytes linked to Alzheimer's disease for the first time. Thoughts health innovators? Alzheimer's disease (AD) is the most common dementia type, with no treatment to slow down the progression of the disease currently available.

[didanawisgi]

[didanawisgi]

An inconvenient amyloidal truth

Tastes sugary