#basic research

[sunnysaystuff]

every time someone says sirius black has blue eyes, a star dies

[robertreich]

The Biggest Deficit You’ve Never Heard Of

America has a deficit problem. But the country’s biggest deficit isn’t the federal budget deficit. It’s the deficit in public investment. The public investment deficit is the gap between what we should be investing in our future — on infrastructure, education, and basic research — and the relatively little we are investing. Increasing public investment needs to be a major goal of the Biden administration.

Public investment is similar to private investment in that we invest today because of the payoff in the future. The difference is public investment pays off for all of us, for America. 

In the 1960s, we used to make a lot of public investments. But they’ve been steadily declining ever since.

That decline has been largely driven by so-called “deficit hawks” who argue against more federal spending. But as I've been saying for years, reducing the federal deficit just for the sake of reducing it makes no sense. 

Any business person knows that you borrow money for the sake of investing in the future of your business. Those are wise borrowings. Because then you can pay those debts off when they get bigger. 

A national economy works exactly the same way. It doesn’t matter that we’re borrowing money, if we’re investing those monies that we borrowed from abroad — in education, training, infrastructure, factories — but we’re not.

The public return on infrastructure investment, based on 2020 report taking into account the pandemic, averages $2.70 for every single public dollar invested — yet we haven’t made those investments. Our infrastructure today is crumbling.

The return on early childhood education is between 10 and 16 percent — but only a handful of our children have access to early childhood education. 

Public investment on clean energy has an annual return of over 27 percent. But federal tax breaks favor fossil fuels over renewables by about 7 to 1.

The public return on investments in basic research and development are huge. America’s competitiveness depends on them, because no individual company has an incentive to make them. The lithium-ion battery that powers iPhones and electric cars was developed by federally sponsored materials science research, while the Internet itself was borne out of the Advanced Research Projects Administration. 

And yet in recent years, public investment in basic research has declined as well. 

Are you seeing a pattern yet? Federal investments in all these areas have shrunk — even though the payoffs from these investments are gigantic, and the costs of not making them are astronomical. American productivity is already suffering.

Now, some say we don’t need to worry about this public investment deficit because private investments fill the gap. Baloney.

Corporations are focused on getting the best return for themselves, not for America. For most of the last four decades, they’ve made money by lowering their costs, at the expense of working people: capping wages, reducing taxes, and deregulating.

A common assumption is that when American corporations are profitable, Americans are better off. But that's false. Trickle-down economics is a sham. Tax cuts and subsidies to big corporations and the wealthy don’t build the economy. Economies don’t grow from the top down — they grow from the bottom up, through public investment.

So if private investment won’t fill the gap, how do we fill it? Two ways: tax the wealthy and large corporations, and borrow.

Tax rates on the wealthy and on corporations have continued to drop over the past 40 years, just as the deficit in public investment has grown. In the 1950s, the highest tax rate on individuals was over 90 percent. Even after tax deductions and credits, it was still over 40 percent. But since then, tax rates have dropped dramatically. For the first time on record, the 400 richest Americans now pay a lower effective tax rate than people in the bottom half. Revenue from corporate taxes has also plummeted.

If wealthy individuals and corporations want all the advantages that come with being American, they have to pay taxes so America can afford the public investments necessary for a high-wage, high-productivity society.

The other way to pay for public investment is through public borrowing. This kind of borrowing doesn’t burden future generations, because it’s used to build a better future for those future generations. 

Remember: There’s a difference between borrowing for the future and borrowing for today. You might not want to borrow to pay for a vacation, but it’s perfectly rational to borrow to purchase a house, because a vacation doesn’t have any future return, while a home does. Right now, the federal budget irrationally treats all government borrowing the same.

The government needs a public investment budget separate from the current spending budget to clarify what we’re investing in and allow us to keep borrowing for investments as long as the returns justify it.

Public investment is the biggest and most important deficit you’ve never heard of. 

Don’t listen to people who claim we can’t afford to invest in the American people. We can afford it. We can’t afford not to. Joe Biden needs to recognize this, and make public investment a central part of his economic strategy. 

[miss-biophys]

Experimental therapy extended lifespan of mice by 1/4 🐁

...according to an impressive experimental study published in Nature Communication in June 2021. https://www.nature.com/articles/s41467-021-23545-7

Overexpression of an important protein SIRT6, which regulates aging and metabolism in mice and humans, lead to lifespan expansion in both male and female mice. It reduced age-related metabolic decline in energy metabolism and inhibited frailty. As such, it controls lifespan and the ability to generate energy at times of its limited availability, such as physical activity, fasting and aging. 

I especially adore one of the tests, the researchers performed to observe the vitality of their mice — How eager they are to spontaneously run in a wheel. 😄🐁

Interestingly enough, the same protein is responsible for healthy aging in humans too. If we could think of a drug/food supplement, which would increase the levels of protein SIRT6 in human body, let’s say in people above 50, we could extend the lifespan of people well above 100 years. Cohen Lab of Molecular Mechanism Of Aging in Israel is already working on it.

This research is a brilliant example of how the curiosity driven basic science leads to interesting and important applications.

[autisticadvocacy]

This young scientist studies wild animals. Bias against disability won’t stop her

Field biologist Charlotte Devitz is part of a trend: researchers expanding the boundaries of accessible science.

“Especially after I had to start using a wheelchair, I didn’t think I could stay in STEM,” 

[intentandoseringeniero]

Adoro de verdad los videos de Destin. Esto parece una chorrada, pero lleva un montón de tiempo analizando cómo funciona la reacción en cadena de fichas de dominó y sólo por como lleva al límite esto llegando a sacar datos por fuerza bruta ya merece la pena :) Y es bueno que haga ese énfasis en la investigación básica, porque es la que hace que sigamos adelante. No sirve "para nada" a corto plazo, pero siempre suele haber alguien que el día de mañana or encuentra utilidad. Si a Gauss no le hubiera dado por definir la raíz de menos uno como la unidad compleja y demostrar el teorema fundamental del cálculo prácticamente ninguna de las ingenierías que conocemos serían lo que son ahora.

[excessively-english-jd]

Creationist: If Lucy is the only one we’ve found....

Me: *does a basic google search and discovers 9 other specimens of A. afarensis, of which Lucy wasn’t even the first discovered*

[miss-biophys]

Insight into the up to date research aiming to fight resilient bacteria that thread people all around the world.

https://www.youtube.com/watch?v=eMDIkMzqjus

Have you heard about antimicrobial resistance? And did you know that not only pharma development, but also basic research helps with this problem? Have a look on the up to date research aiming to fight resilient bacteria that threat people all around the world. Presented by: Adéla Melcrová, PhD alias Miss BioPhys

I am immensely proud of my research line during my postdoctoral stay in Groningen, Netherlands! It’s super interesting, super novel, and super important.

Clearly, biophysics can save lives too!