Dec 30, 2025
Mechanism of action of Butein in cutaneous squamous cell carcinoma through regulation of the TWEAK-FN14 signaling pathway - Research
Background: The incidence of cutaneous squamous cell carcinoma (cSCC) continues to rise, while current therapeutic approaches remain limited in efficacy for patients with advanced disease. The natural polyphenol Butein has demonstrated antitumor activity in various malignancies; however, its role and underlying mechanisms in cSCC remain unclear. Our previous study revealed that the TWEAK-FN14…
#Action#Butein#carcinoma#cell#cutaneous#doi:10.3389/fonc.2025.1725848#Lili Liang#Mechanism#MEDLINE#National Center for Biotechnology Information#National Institutes of Health#National Library of Medicine#NCBI#NIH#NLM#pathway#PMC12738174#pmid:41458609#PubMed Abstract#Qinyi Dong#Regulation#research#Signaling#squamous#TWEAKFN14#Zijian Zhang