#cb2 receptor

[unitedpatientsgroup]

Breast Cancer, Cannabis, and Tamoxifen: Understanding the Dangers of Drug-Drug Interactions

https://unitedpatientsgroup.com/blog/2017/08/31/breast-cancer-cannabis-and-tamoxifen-understanding-the-dangers-of-drug-drug-interactions/

For many people living with life-limiting and life-threatening diseases like cancer, medical cannabis has long been hailed as a gift, both for symptom control and for its potential to limit the disease process itself.

[vthornleymd]

A review on pre-clinical cannabinoid studies: anti-angiogenesis and reduction of MMP-2 expression inhibiting cancer cell growth

A review on pre-clinical cannabinoid studies: anti-angiogenesis and reduction of MMP-2 expression inhibiting cancer cell growth

Virginia Thornley, M.D., Neurologist, Epileptologist

June 24, 2018

@VThornleyMD

https://neurologybuzz.com/

Introduction

The surge of recognition of the medical significance of the cannabis sativa can no longer be ignored. frustrated with the futility of current pharmaceutic agents, their associated side effects and costs, there is a growing tendency for more natriceutic measure of therapy.…

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[vthornleymd]

Cannabinoids in obsessive-compulsive disorder: mechanisms and effectiveness in the animal model

Virginia Thornley, M.D., Neurologist, Epileptologist

June 16, 2018

Introduction

Obsessive compulsive disorder is well known to the lay as someone who is excessive interested in keeping their environment clean and orderly. It is a neuropsychiatric condition, where thoughts or actions are repetitive. Usually in involves the complex balance of neurotransmitters withing the nervous system so that…

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[vthornleymd]

The fatal effects and mechanisms of synthetic cannabinoids including JWH compounds used recreationally

The fatal effects and mechanisms of synthetic cannabinoids including JWH compounds used recreationally

Virginia Thornley, M.D., Neurologist, Epileptologist

@VThornleyMD

May 31, 2018

Introduction

While advocacy groups are well-versed and even the public is aware of the increasing popularity of marijuana use for medical purposes, with many research studies ongoing, there is the darker side of the equation from which the stigma first grew, its intent for recreation and subsequent abuse.

There are…

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[vthornleymd]

Part VIII Medical Marijuana video series: tetrahydrocannabinol, cannabidiol and use in Parkinson’s disease

[cannatuga]

[cannatuga]

We have studied the status of some of the components of the endocannabinoid system, fatty acid amide hydrolase and cannabinoid CB1 and CB2 receptors, in postmortem brains from patients with Alzheimer’s disease. [...] Our results show that both fatty acid amide hydrolase and cannabinoid CB2 receptors are abundantly and selectively expressed in neuritic plaque-associated astrocytes and microglia, respectively, whereas the expression of CB1 receptors remains unchanged. In addition, the hydrolase activity seems to be elevated in the plaques and surrounding areas. Thus, some elements of the endocannabinoid system may be postulated as possible modulators of the inflammatory response associated with this neurodegenerative process and as possible targets for new therapeutic approaches.

[...] it is currently accepted that although the cannabinoid CB1 receptors are present in different tissues (predominantly of nervous origin), the cannabinoid CB2 receptors are restricted to cell types related to the immune function. CB1 receptors are widely expressed in the CNS, being specially abundant in basal ganglia, hippocampus, cerebellum, and cortical structures. This pattern of distribution matches well with the known effects of cannabinoids on motor and cognitive functions.

AD is a chronic degenerative disorder of the brain and accounts for the most common form of dementia in the elderly. The histopathology of AD is currently well known, with hallmarks including senile plaques, neuritic tangles, loss of neurons, damaged synaptic connections, and reactive gliosis. [...] the formation of complex protein aggregates containing A  is thought to induce a chronic inflammatory response that leads, among other events, to the activation of both microglia and astroglia. These are known to play a relevant pathophysiological role, because they produce abundant proinflammatory substances that initiate a secondary damaging process. The aim of this study was to determine the status of some components of the endocannabinoid system, CB1 and CB2 receptors and FAAH, in the brains of AD patients and to explore their possible role in this neurodegenerative disorder. We report that FAAH protein and activity and CB2 receptor protein are selectively overexpressed in glial cells that are linked to the inflammatory process that accompanies Alzheimer’s disease. To our knowledge, this is the first observation in human tissue that suggests a role of the ECS in the progression of this neurodegenerative disease.

[...] this report is the first evidence for the presence of CB2 receptors in the human CNS. [...] these receptors have recently been reported to play an important role in microglial migration. It is important to note that we detected CB2 receptors only in microglial cells, which is in agreement with the well known immunomodulatory effects of CB activation. Thus, many studies have shown that CB2 receptor activation leads to a myriad of changes in the production of inflammation-related substances, although with results that vary depending on the experimental model used and the concentration of cannabinoids used. In any case, the selective presence of CB2 receptors in microglial cells opens new perspectives on the role of CB receptors in the human CNS and suggests that the modulation of their activity may have therapeutic implications.

[gwmac]

Racism and Homophobia Behind Removal of HIV from Medical Marijuana Bill

Racism and Homophobia Behind Removal of HIV from Medical Marijuana Bill

  The latest news on medical marijuana is not good news for the thousands of Georgians with HIV or AIDS. Gone from HB-1 also known as Haleigh’s Hope Act are:  Glaucoma, AIDS, ALS, Alzheimer’s disease, Muscle spasticity disorder, PTSD, Autism, Sickle cell anemia, Tourette syndrome, A terminal illness that involves severe pain, nausea or wasting.

People with any of these conditions will not be…

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