Thinking ENA thoughts. Ok so yknow how theres the little alcove in the wall by the Taxi Driver's heads and that, with some out-of-boundsing, you can see this scene
So. ENA is Unforgiven, as a character trait. Here is a character, forgiving her, in priestly robes and stance while she appears to be trying to sell him something (before disappearing when you look away). Now, when we reach the Uncanny Streets, we see the polygonal, two-headed creatures (which the wiki refers to as The Wanderers) more as beasts or surveillance machines. They can't be spoken to, seem to rove the landscape mindlessly, and the only one we DO get to interact with is treating a building like a chew toy. It is, as per the achievement, a weird dog.
Assuming some idea of linear time between these iterations of The Wanderer-- which, lets be clear, is NOT A GIVEN-- then the only character who expressly forgives ENA suffers a terrible fate, stripped of personhood, doomed to wandering where they once had a role, and removed from the ability to make any impression on others besides a vague and intimidating beast-machine.
Writing this out, it reminds me of how people seem to percieve ENA herself, with the exception of her purpose being demonstrated constantly.
Parallels aside, this could be just another devastating example of the carnage ENA leaves in her wake. She goes in to conduct business and is inexplicably blamed for something she hasn't even done yet. She is forgiven for it, but it is still attributed to her before it happens. For whatever reason, the same individual loses everything. Coincidence seems unlikely to me, even if nothing ENA did was directly at fault-- just like every other act of destruction her business leads to.
And in a world where people's relationship with death seems to be slippery and trivial, the fates given the most gravity seem to be transformations. From blob man or pants to misshapen popsicle, from person to Wanderer.