#chronickidneydisease

[ayurvedickidneyworld]

SYMPTOMS OF KIDNEY FAILURE

Subscriber Our YouTube Channel For More Updates On #KidneyHealth :https://youtu.be/0qw8O87yVi8

[ayurvedickidneycareinindia]

The best diet for your kidney's such be based on YOU. ⁣⁠ ⁣⁠ The old kidney diet focused on restriction- limit this, limit that- and was not developed with the idea that all foods can fit!⁠

[researchchla]

CHLA Scientists Develop Breakthrough In Vitro Model

Scientists at Children’s Hospital Los Angeles develop first physiologically-accurate in vitro model of the human kidney glomerulus, representing a milestone in the field of kidney disease research

Kidneys work to constantly filter blood and remove toxins from the body. Conditions such as chronic kidney disease (CKD) are characterized by a reduced ability to perform this essential function. CKD incidence is growing and more than 1.4 million individuals depend on dialysis or kidney transplant for survival. Development of new treatments requires an understanding of the mechanisms of the disease progression, but scientists have not been able to accurately model kidney filtration in vitro – until now.

In a landmark study published in Nature Communications, scientists at Children’s Hospital Los Angeles demonstrate an in vitro kidney model that could change the course of research for diseases like CKD.

The kidney contains specialized structures called glomeruli. Within each glomerulus is a filtration barrier made up of two thin layers of highly specialized cells and a membrane that acts as a selective filter. As blood moves through each glomerulus, toxins and small molecules can pass through, while proteins and other important components are kept in the bloodstream. “This filtration process breaks down in patients with kidney disorders,” explains Laura Perin, PhD, who is co-senior author on the study along with Stefano Da Sacco, PhD. “But because we haven’t had a good in vitro model, we still don’t know the mechanisms of injury to the glomerulus in CKD.”

Dr. Perin and Dr. Da Sacco conduct research in the GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology along with co-director Roger De Filippo, MD, at CHLA’s Saban Research Institute. The lead author on the study was CHLA postdoctoral research fellow Astgik Petrosyan. Together, the team studies the structure of the glomerulus to better understand how and why their ability to filter blood breaks down.

“A big challenge in the kidney research field has been trying to replicate the glomerulus in vitro,” says Dr. Da Sacco. “In particular, the glomerular filtration barrier is very difficult to recreate in a lab using standard techniques.” Because of this, most published studies have used an artificial membrane between the two cell layers. While fluid can be exchanged, the cells cannot communicate across this membrane in the same way they do biologically. “This results in a model that doesn’t really filter properly,” he explains.

The critical component missing from current experiments is a filter that is selective and allows proper cell-to-cell communication. Dr. Da Sacco and Dr. Perin set out to grow healthy kidney cells in a way that allowed for the natural glomerular barrier to form, just as it does in the body. Using specialized, compartmented containers called OrganoplatesTM, the investigators did exactly that.

The result?

A model glomerulus that functions nearly identically to that found in real kidneys. They are calling this model, which is derived entirely from healthy, human kidney tissue, a glomerulus on a chip.

On one side of the cells, investigators add fluid and, on the other side, they collect what the ‘glomerulus’ filters, which is called the filtrate. In their experiment, the scientists added blood serum from healthy individuals. Without the use of a manufactured filter, the team’s in vitro glomerulus behaved as human kidneys are expected to act: proteins remained in the serum while smaller molecules passed into the filtrate. “The barrier that our cells naturally formed is selective, just as it would be in a fully-functioning kidney,” says Dr. Da Sacco. “It is remarkable.”

This model represents a substantial leap forward from the current standard of in vitro kidney research. “Our system behaves like a biologically, physiologically correct glomerulus,” says Dr. Perin. “This opens up the door for us to understand what we still don’t know – the molecular mechanisms of injury in CKD and, more importantly, how to prevent damage.”

While this seemed a distant goal in the past, Dr. Da Sacco and Dr. Perin are already recreating and studying the disease state in their model. When the investigators added serum from patients with CKD, they found that the glomerulus exhibited the same type of damage observed clinically: proteins began to leak through the compromised filter. Protein levels measured in the experimental filtrate matched patient clinical filtrate samples with a correlation of approximately 90%.

This breakthrough paves the way for numerous clinical applications. In the burgeoning era of personalized medicine, a preparation such as this can be used to examine molecular mechanisms of kidney damage in individual patients. Disease progression can also be monitored over time using serial blood sampling. Also, the model could be used for screening new drugs prior to human clinical testing.

Dr. Perin and Dr. Da Sacco, who are also Assistant Professors in the Keck School of Medicine at USC, are co-senior authors on the publication. Other authors are Paolo Cravedi of Icahn School of Medicine at Mount Sinai, NY; Valentina Villani of CHLA; Andrea Angeletti of the University of Bologna, Italy; Joaquin Manrique of Complejo Hospitalario de Navarra, Pamplona, Spain; Alessandra Renieri of Azienda Ospedaliera Universitaria Senese, Siena, Italy; and Roger De Filippo of CHLA.

The study was funded by the GOFARR Foundation and the Schenkman Family, grants from the Alport Syndrome Foundation, a TSRI Research Career Development Award, and a Wright Foundation Pilot Award. OrganoplatesTM were purchased from MIMETAS, who the authors wish to thank for providing invaluable training, technical support, and assistance.

Healthy human kidney cells (visible in red and green in this fluorescent image) grow in layers to form a filtration barrier in vitro. Image courtesy of Dr. Perin and Dr. Da Sacco.

[drchandanchaudhari]

Hemodialysis & Peritoneal Dialysis in Mumbai – Dr. Chandan Chaudhari 

Dr. Chandan Chaudhari offers the best dialysis treatment in Mumbai with a caring and professional approach. We provide dialysis, kidney monitoring, and full support services to ensure safety and comfort. Our team focuses on effective treatment and expert guidance for every patient. Experience personalized care and trusted kidney services. Book your appointment today to begin your treatment.

[kosuruhospital-blog]

Kidney Transplant – Restoring Life, Restoring Health 🫘

A kidney transplant replaces a failing kidney with a healthy donor kidney, helping restore normal kidney function and significantly improving quality of life for patients with chronic kidney disease. The procedure involves careful donor matching, surgical placement of the new kidney, and connecting it to the recipient's blood vessels, ureter, and bladder for proper functioning.

At Kosuru Kidney & Skin Hospital in Narasaraopet, experienced nephrologists guide patients through every step of the transplant journey — from evaluation and donor compatibility testing to post-surgery care and recovery support.

📍 12-16-7/1, Next to R&B Office, Prakash Nagar, Narasaraopet, Andhra Pradesh 522601 📞 8333833210 / 9059906939

[bestwebsitedesignservicesin]

Nephrologist in Gurugram

Healthy kidneys are essential for a healthy life. They filter waste, balance body fluids, regulate blood pressure, and support many important body functions. If you're experiencing kidney-related symptoms or have conditions like diabetes or high blood pressure, consulting an experienced nephrologist in Gurugram can help you receive timely diagnosis and effective treatment.

A nephrologist is a specialist who diagnoses and treats kidney diseases, including chronic kidney disease, kidney infections, kidney failure, electrolyte imbalances, and other disorders affecting kidney function. Early medical attention can help prevent complications and protect your long-term health.

Common Signs of Kidney Problems

Swelling in the feet, ankles, or face

Blood in the urine

Foamy urine

Frequent or reduced urination

High blood pressure

Persistent fatigue

Nausea or loss of appetite

Difficulty concentrating

If these symptoms continue, it is important to seek medical advice from a qualified nephrologist in Gurugram.

Diagnosis and Treatment

Doctors evaluate kidney health through blood tests, urine analysis, kidney function tests, ultrasound, and other diagnostic procedures when needed. Based on the diagnosis, treatment may include medications, lifestyle changes, dietary guidance, blood pressure control, diabetes management, or long-term monitoring to preserve kidney function.

Tips for Healthy Kidneys

✔ Drink enough water every day.

✔ Eat a balanced and nutritious diet.

✔ Maintain healthy blood pressure.

✔ Control blood sugar levels if you have diabetes.

✔ Exercise regularly.

✔ Avoid smoking and excessive alcohol consumption.

✔ Schedule routine health check-ups.

Choosing an experienced nephrologist in Gurugram ensures personalized care, accurate diagnosis, and effective treatment for a wide range of kidney conditions. Early diagnosis and proper management can help protect your kidneys and improve your overall quality of life.

[drchandanchaudhari]

Chronic Kidney Disease Treatment in Mumbai | Dr.Chandan Chaudhari

Searching for chronic kidney disease treatment in Mumbai? Dr. Chandan Chaudhari offers trusted medical care and ongoing kidney support. Cont

CKD Specialist in Mumbai | Dr. Chandan Chaudhari

Dr. Chandan Chaudhari offers chronic kidney disease treatment in Mumbai with 21+ years of nephrology experience at Wockhardt and Jaslok Hospital. He follows international CKD guidelines to slow kidney damage, improve function, and guide every patient at every stage. Healthy kidneys start here. Book your consultation.

[hiimsjabalpur]

10 Common Causes of Blood in Urine You Should Never Ignore

Seeing blood in urine can be alarming. Whether the urine appears pink, red, or brown, it is a sign that should never be ignored. Sometimes t

From urinary tract infections to chronic kidney disease, there are several possible reasons behind blood in urine. Knowing these warning signs can help you take timely action. Discover the most common causes and supportive Ayurvedic approaches for kidney wellness.

Mobile: [phone] Book Appointment: https://hiims.in/clinic/jabalpur/book-an-appointment