Chronic hepatitis C is very common condition prevailing worldwide. In Pakistan, its prevalence is about 5.9%. Now, there is no vaccine available for HCV prophylaxis, so focus must be toward the treatment of HCV through combination therapy. Combination of peg-interferon alpha and ribavirin exhibits strong potential for treating Hepatitis C and at present, reported as standard treatment. Patients infected with genotype 1 and do not have any previous HCV treatment are subjected to 8 week course of treatment with ledipasvir and sofobuvir so; the treatment is limited according to fibrosis stage and baseline viral load. Ribavirin free regimens-oral interferon and elbasvir-grazoprevir are presenting as a new therapeutic treatment for HCV. End point of this therapy is sustained virological response which is aviremia condition developed after 24 weeks of therapy however, end treatment response is a condition after completion of therapy. The main goal of anti-HCV combination therapy is to eliminate HCV infection and complications associated with extrahepatic tissues and liver diseases including cirrhosis, fibrosis, hepatocellular cancer and death.
