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Engineered commensals for metabolic modulation of the gut-liver-brain axis - Research
Engineered Lactobacillus plantarum strains metabolize ammonia and reshape amino acid balance in hepatic encephalopathy. In two mouse models, treatment lowers blood and brain ammonia, improves anxiety-like behavior, and preserves gut microbiota diversity, while the engineered strains are cleared after dosing stops. Read more about this post… Credits: Source Disclaimer
Commensals join the effector game - Immunology Research
Nature Immunology, Published online: 24 March 2026; doi:10.1038/s41590-026-02467-w Bacterial type III secretion systems, traditionally viewed as virulence factors, are prevalent in healthy gut microbiomes, where they deliver effectors that modulate human immune signaling and influence susceptibility to inflammatory diseases. Read more about this post… Credits: Source Disclaimer
5-MethylcytosineDNA Methylation Patterns among Gut Predominate Commensal Escherichia coli and Lactobacilli from the Balbas and Mazekh Domestic Sheep Breeds -Crimson Publishers
5-MethylcytosineDNA Methylation Patterns among Gut Predominate Commensal Escherichia coli and Lactobacilli from the Balbas and Mazekh Domestic Sheep Breeds by Pepoyan AZ* in Research in Medical &Engineering Sciences
The aim of current investigation was to compare the 5-methylcytosine level in genomic DNA of commensal Escherichia coli and lactobacilli from the widely bred in Armenia sheep breeds-Mazekh and Balbas. The results revealed statistically confirmed differences in5-methylcytosine methylation patterns of these bacteria in the bacterial isolates from Mazekh and Balbas sheep. The percentage of 5-methylcytosine of the genomic DNA was statistically higher for isolates from the Mazekh sheep in comparison with those of Balbas sheep (34.5±7.57 vs. 5.05±2.4, P <0.05). The Scatter Plot of relationship between cell surface hydrophobicity and genomic DNA’s 5-methylcytosine levels shows a moderately strong negative relationship between these characteristics of sheep gut isolates (Pearson R is -0.75). These results may be important for veterinary medicine and breeding programs.
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