#enzymes notes

[er-cryptid]

DNA Polymerase I

-- first DNA polymerase discovered

-- discovered by Sylvy Levy and Arthur Kornberg

-- an enzyme

-- isolated from E. coli

-- involved in prokaryotic DNA replication

-- member of the alpha/beta protein superfamily

-- alpha-helices and beta-strands occur in irregular sequences

-- directs DNA synthesis

-- requires DNA template to read

-- requires all four deoxyribonucleoside triphosphates to grow the complementary strand

-- mediates proofreading

-- involved in DNA repair

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