#factsisaac

[factsisaac]

If you save and quit in Mother's room right after beating her, the boss door reappears.

You can use this to play the self-sacrifice room and go to the Dark Room, progressing your run further than Corpse II.

This also still counts for the Mother post-it unlock as well.

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[factsisaac]

If Isaac dies to a Grudge, he explodes into bits and pieces of meat.

This death animation is unique to Grudges, so if you want to see Isaac exploding without any mods, be my guest!

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[factsisaac]

Happy New Year!

You can celebrate with some fireworks by donating 999 coins to the Greed Donation Machine.

May this year be a year of healing and excitement! 🐲

[factsisaac]

If you check the room names for the Mines Chase in The Binding of Isaac: Repentance, all of them have names describing the room layout.

For example, Mineshaft Room (big straight), or (big curve).

Funnily enough, however, there is one room called Mineshaft Room (big hetero).

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[factsisaac]

The orange champion variant of Little Horn damages himself very slightly when he spits out a bomb.

You can use this to your advantage if you're really really patient.

Is he stupid?

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[factsisaac]

The profanity list for The Binding of Isaac: Repentance's Co-op is lifted straight from Minecraft's profanity list, meaning you can't say certain items or terms that Isaac uses with the in-game text chat.

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[factsisaac]

The text that appears when you activate the item "Whore of Babylon" and the Reversed Empress card come directly from Castlevania II: Simon's Quest, right down to the UI.

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[factsisaac]

According to Edmund McMillen, the creator of The Binding of Isaac, the characters Jacob and Esau represent Isaac's balls.

The Jacob and Esau illustration was created by my friend @cheengo!

Asking them to draw "Jacob and Esau Balls Please" was very scary.