#glycogenolysis

[twothreefiveeight]

Glycogen degradation. 📖

[biology-geology-beaches-india]

The Scientific Research Notes of S. Sunkavally (years 2002-2011).

3367.

[heliotrope155]

You guys are so lucky I'm not an enzyme, because let me tell you if you guys undid all the work I did to fucking make those glycogen branches, you're on your own babe, I quit.

[collegeandknowledge]

Glycogen Breakdown

Phosphorylase b is activated to phosphorylase by the enzyme phosphorylase b kinase. Phosphorylase b kinase is activated by protein kinase A or high calcium level. Once phosphorylase b kinase is activated by protein kinase a, it activates phosphorylase b to its active form called phosphorylase a. Phosphorylase a breaks glycogen to glucose-1-phosphate. Phosphoglucomutase converts glucose-1-phosphate to glucose-6-phosphate.

[collegeandknowledge]

To make glycogen: glucose-6-phosphate is converted to glucose-1-phosphate via phosphoglucomutase, glucose-1-phosphate is converted to UDP-glucose via UDP-glucose pyrophosphorylase and UTP, and lastly glycogen synthase converts UDP-glucose to glycogen.

To break down glycogen for glucose: glycogen is broken to glucose-1-phosphate using phosphorylase, glucose-1-phosphate is converted to glucose-6-phosphate using phosphoglucomutase, then in the liver glucose-6-phosphate is converted to glucose using glucose-6-phosphatase.

[delphic-dreams]

Trying intermittent fasting

The studies on it seem really promising. The way i eat tends to swing that way naturally anyway, but the typical advice to eat small portions often with the idea that it "speeds up metabolism" is so wrong, I think it's the opposite. definitely isn't optimal for glycogenolysis. I'm finding this fits my lifestyle really well and I think the results will be good longterm.

[mdintraining]

Glycogen Synthesis and Glycogenolysis

[collegeandknowledge]

Insulin is an anabolic hormone. It upregulates glycogen synthase. Glucagon upregulates glycogen phosphorylase. AMP causes more glucose release. Epinephrine upregulates glycogenolysis. High levels of calcium upregulate glycogen phosphorylase.