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The number of people diagnosed with gonorrhoea in England in 2023 was its highest since records began in 1918.
Wrap it up.
Massachusetts has identified two cases so far that were infected by the strain, which appears to have developed some resistance to ceftriaxo
Excerpts:
Health authorities in Massachusetts announced Thursday they have identified two cases of a new strain of gonorrhea that appears to have developed resistance to a broad swath of antibiotic treatments.
Both patients got better after getting injections of ceftriaxone, the main drug currently recommended to treat cases of the sexually transmitted infection. But state health officials warn the strain that infected themheal shows signs of at least some resistance to almost every drug to treat the bacteria, the first of its kind confirmed in the U.S. to date.
...
In 2013, the CDC named gonorrhea as one of the three most urgent threats posed by antibiotic-resistant bacteria. Both U.S. and world health authorities have launched campaigns to curb new cases of gonorrhea in hopes of controlling the bacteria until vaccines and new treatments are developed.
Partners in Crime
Gonorrhoea, chlamydia, genital herpes, human papillomavirus (HPV) – all of these infections target the womb entrance, the cervix. A lack of cervical models makes studying these infections difficult. Researchers now present cervical organoids, made from human ectocervical [vaginal end of the cervix] cells, to investigate infection with a cancer-causing strain of HPV alone or in combination with chlamydia. Half of the organoids were genetically manipulated to introduce HPV genes into their DNA, mimicking what happens during HPV infection. Fluorescence microscopy revealed HPV organoids (pictured, right) matured similarly to non-HPV organoids (left) but with signs of precancerous lesions. When infected with chlamydia both types of organoid showed changes in gene activity relating to the cells' immune responses. Notably, chlamydia co-infection suppressed genetic changes that HPV is known to cause that promote DNA repair. The organoid model, therefore, highlights how coinfections change how the cervix responds, potentially affecting cancer progression in HPV infections.
Written by Lux Fatimathas
Image adapted from work by Stefanie Koster and Rajendra Kumar Gurumurthy, and colleagues
Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany
Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
Published in Nature Communications, February 2022
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Morphology of Neisseria gonorrhoeae.......readily grow in a media containing Blood or Serum, commonly Blood Agar medium, and Mueller Hinton Agar medium is used for the cultivation of Neisseria gonorrhoeae in Laboratory..... Check out the Culture Characteristics of Neisseria gonorrhoeae.....
Morphology of Neisseria gonorrhoeae.......readily grow in a media containing Blood or Serum, commonly Blood Agar medium, and Mueller Hinton Agar medium is used for the cultivation of Neisseria gonorrhoeae in Laboratory..... Check out the Culture Characteristics of Neisseria gonorrhoeae.....
Race to Resistance
Gonorrhea – caused by the bacteria Neisseria gonorrhoeae (pictured) – is the second most common sexually transmitted infection in the UK. It mainly affects young people under the age of 25, and can have serious health consequences if left untreated. The World Health Organization estimated that 78 million adults were affected worldwide in 2012 and so it’s deemed a public health priority. Over time, gonorrhoea has developed resistance to first-, second- and even third-line antibiotics, with new data showing that 77 countries now have antibiotic-resistant strains of gonorrhoea. This has instigated researchers to call for international collaborations to help control it, which would include updating treatment guidelines in response to regular surveillance of treatment successes and failures, quicker and earlier diagnostic tests, improvements in prevention measures, and new therapeutic drugs. In the long-term, it’s thought that a vaccine for gonorrhoea used together with these strategies could help stop its spread.
Written by Katie Pantell
Image by National Institute of Allergy and Infectious Diseases (NIAID), published on Flickr
Research from the Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland
Image originally published under a Creative Commons Attribution 2.0 Generic Licence (BY 2.0)
Research published in PLOS Medicine, July 2017
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More countries report rising gonorrhoea
The World Health Organization warns that gonorrhoea is increasingly resistant to primary antibiotics like ceftriaxone and cefixime. Resistance to ceftriaxone rose from 0.8% in 2022 to 5% in 2024, while cefixime resistance jumped from 1.7% to 11%. WHO’s Enhanced Gonococcal Antimicrobial Surveillance Programme (EGASP) now includes data from 12 countries across five regions, up from 4 countries in…
More countries report rising gonorrhoea
The World Health Organization warns that gonorrhoea is increasingly resistant to primary antibiotics like ceftriaxone and cefixime. Resistance to ceftriaxone rose from 0.8% in 2022 to 5% in 2024, while cefixime resistance jumped from 1.7% to 11%. WHO’s Enhanced Gonococcal Antimicrobial Surveillance Programme (EGASP) now includes data from 12 countries across five regions, up from 4 countries in…