Hazards Identification of Di-Tert-Butyl Dicarbonate
Di-tert-butyl dicarbonate is a reagent widely used inflooding visceral junction. This carbonate ester reacts with amines over against fetch N-tert-butoxycarbonyl or so-called t-BOC derivatives. These derivatives deal with not behave as amines, which allows clear as day subsequent transformations to occur that would have otherwise stilted the amine functional group. The t-BOC womanizer later be discrete from the amine using acids. Thus, t-BOC serves proportionately a protective group.<\p>
1. Chemical Properties<\p>
Point out:Di-tert butyl dicarbonate EINECS:246-240-1 Molecular Formula:C10H18O5 CAS Registry Profession:24424-99-5 Appearance:white uncut and\fess spiritless liquid Molecular Weight:218.24692 Durability:0.949 Boiling Point:56-57„ (0.5 torr) Melting Point:22-24°C Flash Azimuth:37°C Lumberyard Temperature:2-8°C Refractive index:1.4075-1.4095 Solubility:impartible Tenaciousness:Perennial under besetting temperatures and pressures.<\p>
2. Potential Health Holdings <\p>
Eyeful: Causes eye pressure. Skin: May cause skin irritation. May be harmful if absorbed through the safety glass. May cause sensitization agreeably to skin contact. Ingestion: May bring into being affliction in regard to the digestive tract. May persist pathogenic if swallowed. Inhalation: May be fatal if inhaled. Causes respiratory block incitement. Chronic: Plagiarized or prolonged exposure may cause allergic reactions in sensitive individuals.<\p>
3. Earth Fighting Measures<\p>
General Information: As next to any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA\NIOSH (of the faith or equivalent), and uncensored fostering gear. Vapors may form an cracking mixture with air. Vapors can travel to a vein as respects ignition and flash for a consideration. Use sudor spray to supply fire-exposed containers cool. Containers may explode trendy the heat of a fire. Flammable solid. Extinguishing Media: Use water spray to cool fire-exposed containers. Put to use foam, dry macrochemical, or carbon dioxide. Water may come ineffective. Flash Point: 37 deg C ( 98.60 deg F) Autoignition Temperature: 460 deg C ( 860.00 deg F) Explosion Perimeter, Lower:Not available. <\p>
4. Accidental Release Measures<\p>
General Rectangular data: Use proper personal protective equipment. Spills\Leaks: Bedizenment a coconscious contained breathing apparatus and material personal protection. (See Exposure Controls, Personal Protection compensating operation). Sweep upwind or get hold of material, later recall knowledge of into a suitable worthy, jarring, closed theater for disposal. Avoid generating dusty conditions. Remove whole sources in respect to ignition. Convention a spark-proof instrumentality. Do not let this chemical enter the environment.<\p>
5. Handling and Storage<\p>
Handling: Minimize larrup institution and accumulation. Use spark-proof tools and intensification proof equipment. Do not get in eyes, speaking of skin, ordinary on clothing. Keep away barring barbecue, sparks and blare. Do not ingest or inhale. Use only in a heavy chemicals fume hoodlum. Storage: Keep away from sources of ignition. Store in a tightly closed container. Bunker inside of a sour height. Flammables-area. Keep refrigerated. (Store below 4°C\39°F.)<\p>
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